Navigation Links
Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
Date:7/11/2012

Wednesday, July 11, 2012, Cleveland: Cleveland Clinic researchers have discovered that a naturally occurring molecule may play a role in preventing plaque buildup inside arteries, possibly leading to new plaque-fighting drugs and improved screening of patients at risk of developing atherosclerosis.

Sometimes called hardening or clogging of the arteries, atherosclerosis is the buildup of cholesterol, fatty cells, and inflammatory deposits on the inner walls of the arteries, restricting blood flow to the heart. The disease can affect the arteries in the heart, legs, brain, kidneys, and other organs, and is the most common cause heart attacks, strokes, and peripheral vascular disease.

At the cellular level, plaque buildup is the result of macrophages in the vessel wall absorbing, processing, and storing cholesterol (lipids) and then accumulating in large amounts, eventually leading to the development of arterial lesions. The researchers, led by Eugene Podrez, M.D., Ph.D., of the Department of Molecular Cardiology at Cleveland Clinic's Lerner Research Institute, have discovered that the naturally occurring molecule Akt3 regulates lipid entry into macrophages and prevents the cells from storing excessive amounts of cholesterol and collecting in the artery.

Podrez says the discovery could lead to new drugs designed to prevent atherosclerosis. It could also help doctors develop screening tests to determine patient risk level for developing the disease. Podrez and his colleagues are now looking into the particular mechanisms behind Akt3's role in regulating lipid processing and will attempt to replicate their results in humans.


'/>"/>
Contact: Wyatt DuBois
duboisw@ccf.org
216-445-9946
Cleveland Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Cleveland Clinic selected to participate in National MDS Clinical Research Consortium
2. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
3. First targeted nanomedicine to enter human clinical studies
4. Clinical insight improves treatment with new lung cancer drug
5. Clinical news alert from the American Academy of Orthopaedic Surgeons
6. Mayo Clinic launches whole genome breast cancer study
7. Mayo Clinic offers newly approved treatment for acid reflux disease
8. NYU Langone experts present research, clinical advances at neurosurgeons meeting
9. Mayo Clinic breast cancer study finds new type of mutation
10. Kroenke honored for outstanding contributions in clinical research training
11. Awards celebrate clinical research that can improve health and alleviate suffering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... ... August 31, 2015 , ... DR. ... Luciana Lagana (aka Dr. Luciana) received a total of three Silver Medal ... Documentary, and Best (Dis)ability Film. Dr. Luciana co-wrote and co-produced this pilot with ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... primary care, is enhancing its existing presence in Tennessee with the opening of ... is the company’s second in Knoxville, sixteenth in Tennessee, and 148th in the ...
(Date:8/31/2015)... Pittsburgh, PA (PRWEB) , ... August 31, 2015 , ... ... that they’ll have a higher body mass index and bigger waist circumference, a 15-year ... , The association did not hold in later years, indicating that young adulthood is ...
(Date:8/31/2015)... (PRWEB) , ... August 31, 2015 , ... With baseball ... play-offs and the World Series will dominate the sports world. Fans desire nothing more ... advance to the final series. For children, especially those who are too young to ...
(Date:8/31/2015)... ... August 31, 2015 , ... Castle Dermatology Institute now welcomes ... Ghasri is a graduate of the University of California, Los Angeles. He graduated summa ... the University of California, Irvine Medical School. As a nationally recognized Regents Scholar, Dr. ...
Breaking Medicine News(10 mins):Health News:Actor/Writer/Director/Psychology Professor Luciana Lagana Receives Three Wins at the 2015 Global Independent Film Awards for the TV Pilot Dr. Luciana on Aging and Falling 2Health News:State-of-the-Art Urgent Care Facility Opening in Knoxville 2Health News:Watching More TV as a Young Adult Predicts Obesity 2Health News:Watching More TV as a Young Adult Predicts Obesity 3Health News:New Children's Baseball Series Offers Young Fans a Way to Celebrate the World Series 2Health News:Castle Dermatology Institute Now Welcomes Dr. Pedram Ghasri to the Practice 2
... 13 Quintiles,Transnational Corp. today announced that its ... College of American Pathologists (CAP)., The central ... the first,quarter of 2007. The facility has seen ... capabilities to a growing test menu., "CAP ...
... a press conference hosted by New York,Attorney General Andrew ... probe of 16 national health insurers regarding an alleged,scheme ... The following is,attributable to Nancy H. Nielsen, M.D., Ph.D., ... York Attorney General Andrew,Cuomo calls into question the validity ...
... of Alberta study, analyzing a sample of over 275,000 ... in physical activity, one size does not fit all. ... when deciding how and if a person wants to ... at the University of Alberta. It is clear that ...
... NEW YORK, Feb. 13 Today, more than ... challenges from,all sides. Internally, the pressure to fill ... generics demand new outcomes from,pharmaceutical marketing and sales ... regulatory (e.g. post-approval monitoring),legislative, and patent issues continue ...
... VALLEY, Calif., Feb. 13 Sun Busters(R), the swim,wear ... and providing,the ultimate in sun protection now sports a ... of Recommendation! Sun Busters is proud,to announce that they ... products that have a UPF of 50+. UPF is ...
... Feb. 13 Statistics released by the,Centers for Disease ... American children is affected by autism. In Georgia, these ... that is rising in,prevalence with alarming speed. It is ... Georgia are affected by autism, a disorder of,unknown origin ...
Cached Medicine News:Health News:Quintiles Central Laboratory in India Receives CAP Certification 2Health News:AMA Commends N.Y. Investigation of Health Insurers 2Health News:Study: When it comes to physical activity, one size does not fit all 2Health News:Legislative and Regulatory Outlook - 2009 and Beyond for Pharma, Biotech Players 2Health News:Sun Busters(R) Now Sports The Skin Cancer Foundation's Seal of Recommendation 2Health News:Sun Busters(R) Now Sports The Skin Cancer Foundation's Seal of Recommendation 3Health News:2008 Georgia Walk for Autism Supporters Gather in Atlanta for Kick-Off Dinner 2
(Date:8/31/2015)... YORK , August 31, 2015 ... they have entered into an exclusive licensing agreement for ... in the estimated $300 million USD veterinary dermatology market, ... (ultramicronized palmitoylethanolamide) to support healthy skin in dogs and ... Italy , and has been received ...
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ... the "Prescription Pain Drugs - Including Opioid, ... Global Markets, Competitors and Opportunities: 2015 - 2020 ... Pain is defined as an ... or potential tissue damage. At some point, everyone ...
(Date:8/28/2015)... , Aug. 28, 2015  Delays in the ... can slow down the decision-making process, resulting in ... absolutely critical for biopharmaceutical companies to develop a ... process for quicker and more meaningful insights. ... Practices, LLC, nearly three-quarters of benchmarked study participants ...
Breaking Medicine Technology:Premune Broadens Portfolio With Novel Innovet Skin Health Product 2Premune Broadens Portfolio With Novel Innovet Skin Health Product 3Premune Broadens Portfolio With Novel Innovet Skin Health Product 4Prescription Pain Drugs Including Opioid, Anticonvulsant, Injectable/ Inhaled, Topical/ Transdermal, Medical Marijuana - 2015-2020 Analysis and Forecasts 2Prescription Pain Drugs Including Opioid, Anticonvulsant, Injectable/ Inhaled, Topical/ Transdermal, Medical Marijuana - 2015-2020 Analysis and Forecasts 3Expediting the Pharmaceutical Market Research Process for Faster Insights 2
... LodgeNet Healthcare , a division of ... integrated patient engagement solutions, announced today the availability ... Patient-Facing Technologies to Improve the Quality of Patient ... to patient engagement that incorporates television-based technology will ...
... Health, one of the top 25 independent healthcare communications ... in the Southwest, won a Manny Award for best ... a national competition honoring creative excellence in healthcare advertising. ... Sound Surgical Technologies, VASER® body shaping systems. Winners were ...
Cached Medicine Technology:LodgeNet Healthcare Whitepaper Explores Key Role of Patient/Family Engagement in Health Reform/Meaningful Use 2LodgeNet Healthcare Whitepaper Explores Key Role of Patient/Family Engagement in Health Reform/Meaningful Use 3LodgeNet Healthcare Whitepaper Explores Key Role of Patient/Family Engagement in Health Reform/Meaningful Use 4LodgeNet Healthcare Whitepaper Explores Key Role of Patient/Family Engagement in Health Reform/Meaningful Use 5HCB Health Wins Manny Award for Best Medical Device Campaign 2
... The RoamAlert Integrity system builds ... ECO. All door controllers in the ... computer running a standard Windows® operating ... the use of a personal computer, ...
... The RoamAlert ECO system ... or several doors. Each exit ... controller. When a resident wearing ... door, the door will lock; ...
... uses RFID to gather patient ... departments such as surgical and ... updates of patient location to ... care events have occurred and ...
... Identification (RFID) helps incorporate people and intelligent ... healthcare value chain. The power of RFID ... automate and optimize business activities in support ... pharmaceutical inventories, RFID offers tremendous potential to ...
Medicine Products: