Navigation Links
Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
Date:7/11/2012

Wednesday, July 11, 2012, Cleveland: Cleveland Clinic researchers have discovered that a naturally occurring molecule may play a role in preventing plaque buildup inside arteries, possibly leading to new plaque-fighting drugs and improved screening of patients at risk of developing atherosclerosis.

Sometimes called hardening or clogging of the arteries, atherosclerosis is the buildup of cholesterol, fatty cells, and inflammatory deposits on the inner walls of the arteries, restricting blood flow to the heart. The disease can affect the arteries in the heart, legs, brain, kidneys, and other organs, and is the most common cause heart attacks, strokes, and peripheral vascular disease.

At the cellular level, plaque buildup is the result of macrophages in the vessel wall absorbing, processing, and storing cholesterol (lipids) and then accumulating in large amounts, eventually leading to the development of arterial lesions. The researchers, led by Eugene Podrez, M.D., Ph.D., of the Department of Molecular Cardiology at Cleveland Clinic's Lerner Research Institute, have discovered that the naturally occurring molecule Akt3 regulates lipid entry into macrophages and prevents the cells from storing excessive amounts of cholesterol and collecting in the artery.

Podrez says the discovery could lead to new drugs designed to prevent atherosclerosis. It could also help doctors develop screening tests to determine patient risk level for developing the disease. Podrez and his colleagues are now looking into the particular mechanisms behind Akt3's role in regulating lipid processing and will attempt to replicate their results in humans.


'/>"/>
Contact: Wyatt DuBois
duboisw@ccf.org
216-445-9946
Cleveland Clinic
Source:Eurekalert

Page: 1

Related medicine news :

1. Cleveland Clinic selected to participate in National MDS Clinical Research Consortium
2. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
3. First targeted nanomedicine to enter human clinical studies
4. Clinical insight improves treatment with new lung cancer drug
5. Clinical news alert from the American Academy of Orthopaedic Surgeons
6. Mayo Clinic launches whole genome breast cancer study
7. Mayo Clinic offers newly approved treatment for acid reflux disease
8. NYU Langone experts present research, clinical advances at neurosurgeons meeting
9. Mayo Clinic breast cancer study finds new type of mutation
10. Kroenke honored for outstanding contributions in clinical research training
11. Awards celebrate clinical research that can improve health and alleviate suffering
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... AB (PRWEB) July 23, 2014 ... of in-home care for seniors, is proud to announce ... Series featuring experts in a wide range of health ... clinical social worker and award-winning author Nancy Kriseman, and ... and ways to prevent burnout by becoming more self-aware. ...
(Date:7/23/2014)... -- Painful or itchy skin lesions could be a ... sometimes have multiple lesions that are suspicious looking, and ... concerns for non-melanoma skin cancers," study author Dr. Gil ... Medicine, said in a Temple University Health System news ... 268 patients who were confirmed to have skin cancer ...
(Date:7/23/2014)... new study supports a growing body of research ... steroid hormones in treating postmenopausal breast cancer, with ... than with standard anti-hormone therapies. The study will ... open-access journal Reproductive Biology and Endocrinology . ... cancer in women in the United States. Approximately ...
(Date:7/23/2014)... The National Institute of Biomedical Imaging and Bioengineering ... Symposium on July 30, 2014 on the NIH campus. ... investigators covering a wide breadth of NIBIB-funded research. ... Cohen, Harvard, Engineering Microbial Rhodopsins as Optical Voltage Sensor, ... Fluorescently Labeled Probes for Nerve Imaging ...
(Date:7/23/2014)... 23, 2014 The American Telemedicine ... ATA’s twentieth annual meeting and tradeshow focused exclusively ... to attract over 5,000 attendees and more than ... May 3-5, 2015, in Los Angeles. , ATA’s ... technology professionals from researchers, clinicians, hospital and university ...
Breaking Medicine News(10 mins):Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 2Health News:Home Care Assistance Calgary to Host Public Webinar on the Topic of Caregiver Mindfulness 3Health News:Painful, Itchy Patches Could Be Sign of Skin Cancer 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5Health News:ATA Seeks Speakers to Present at the World’s Largest Telemedicine, mHealth and Telehealth Conference 2
... Sunset Heal Mountain Retreat & Spa, in Jamaica, ... and spirit, unparalleled personalized attention, and a proactive owner ... her work at Sunset Heal. The first thing ... guests are greeted by the owner, Beatrice Vergano, a ...
... (TSX:HAE), a Montreal-based specialty bio-therapeutics company, announces that it ... Inc. of Vancouver (NASDAQ: ANPI , TSX:ANP) for ... amount of US$2.5 million. Haemacure expects that the bridge ... of approximately ten to twelve months from the date ...
... Infection Study Presented Issuance Of Notice of Allowance of ... today announced that it will launch a significantly more ... Stapler at the Annual Meeting of the American College ... May 4 - 6, 2009. The INSORB(R)|25 Skin ...
... with Flu Preparedness Information from American Red CrossCHICAGO, May ... closing down due to the swine flu (H1N1 flu ... and reliable in-home caregiver options. In response to ... 20 percent discount to Sittercity.com for the month of ...
... Through On-demand Format in First Month , ... Washington, ... Board (PTCB) announced today that since on-demand testing with immediate ... have applied to take the Pharmacy Technician Certification Exam (PTCE) ...
... triage and health advice to EosHealth service subscribers who have ... manage their health through interactive resources via their cell phones, ... proactively reach out to perform triage and provide targeted health ... ...
Cached Medicine News:Health News:Jamaican Destination Spa Offers More Than Just a Magical Experience for the Body, Mind and Spirit 2Health News:Haemacure Signs Term Sheet for Proposed Collaboration and Bridge Financing 2Health News:Incisive Surgical to Launch Next Generation More User-Friendly Absorbable Skin Stapler at American College of Obstetricians and Gynecologists 2Health News:In-Home Caregivers Standing by Nationwide to Support Increased Need Due to Swine Flu 2Health News:Pharmacy Technician Certification Board (PTCB) Now Offers Continuous Testing And Immediate Pass/Fail Results 2Health News:Pharmacy Technician Certification Board (PTCB) Now Offers Continuous Testing And Immediate Pass/Fail Results 3Health News:SironaHealth to Provide 24 x 7 Nurse Line and Clinical Outreach to EosHealth as part of their Mobile Health & Wellness Programs 2Health News:SironaHealth to Provide 24 x 7 Nurse Line and Clinical Outreach to EosHealth as part of their Mobile Health & Wellness Programs 3
(Date:7/23/2014)... , July 23, 2014 UBM Medica ... – a new online community and information resource for ... manage and treat their patients with neurological disorders ... with an aging population, necessitates greater access to dedicated ...  Key statistics on neurological conditions include: , ...
(Date:7/23/2014)... , July 23, 2014 Research and ... Electrocardiograph (ECG) Market by Product, End-user & by Lead ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... segmented into three major segments, namely, holter monitor, resting, ... was valued at $3,683 million in 2013 and is ...
(Date:7/23/2014)... /PRNewswire-iReach/ -- The Centers for Medicare & Medicaid Services ... Improvement Organization (QIN-QIO) contract to a partnership led by ... August 1, WVMI will launch Quality Insights Quality Innovation ... Pennsylvania , Delaware , ... Network will engage providers and the community in multiple, ...
Breaking Medicine Technology:UBM Medica US Launches NeurologyTimes.com 2UBM Medica US Launches NeurologyTimes.com 3Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 2Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 3Announcing a New Regional Approach to Medicare Quality Improvement 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: