Navigation Links
Cleveland Clinic receives grant to study role of DNA damage in treatment-resistant prostate cancer
Date:12/18/2013

Wednesday, December 18, 2013: Cleveland Clinic, along with the National Cancer Institute, the University of Chicago and Thomas Jefferson University, are the recipients of a $600,000 Special Challenge Award from the Prostate Cancer Foundation (PCF) to investigate the role of abnormally high protein levels in prostate tumors.

The increased expression of approximately 25 proteins referred to as interferon-related DNA damage resistance signature (IRDS) correlates strongly with resistance to radiation and chemotherapy. African-American men with prostate cancer are much more likely to have the IRDS signature than Caucasian men, one potential reason for the observed differences in mortality from the disease.

"African-American men have a two-fold higher mortality rate from prostate cancer than European-Americans," said Eric Klein, M.D., Chairman, Glickman Urological & Kidney Institute at Cleveland Clinic, and principal investigator on the grant. "The goal of our research is to further investigate the biology behind the obvious aggressive behavior of prostate tumors in African-American men in the hopes of better understanding its biology and identifying new management and treatment options."

Cleveland Clinic is at the forefront of identifying and addressing health disparities through multidisciplinary clinical care, community outreach and education. In 2003, the Minority Men's Health Center, led by urologist Charles S. Modlin, M.D., MBA, was established in the Glickman Urological & Kidney Institute to address the vast number of medical conditions which disproportionately affect minority men. Approximately 750 patients visited the center this year, in addition to the more than 1,000 men who attend the annual Minority Men's Health Fair each April.

Prostate cancer tumors develop IRDS when exposed to interferons, potent antiviral proteins naturally produced by the body in response to a virus, bacteria or tumor cells. Inteferons were previously thought to prevent tumors from growing; however, research has shown their presence in certain tumors actually inhibits the effectiveness of traditional chemotherapy or radiation. Why this happens more frequently in African-American men is still unknown.

"We don't know whether the tumors themselves or tumor-associated immune cells are the primary sources of the interferon which enables the cancer cells to resist therapy or how such resistance is achieved," said George Stark, Ph.D., staff researcher in molecular genetics in Cleveland Clinic's Lerner Research Institute and principal investigator on the grant. "These questions are being actively investigated in our laboratories."

Part of the study will involve testing drugs conventionally used to treat other cancers to determine if they will block the growth response of prostate tumors when exposed to interferons, improving the tumor's response to chemotherapy or radiation and increasing survival rates. The grant provided by PCF, a philanthropic organization that seeks to fund and accelerate prostate cancer research globally will be also used to study a wide range of other clinical issues in IRDS-positive tumors.

"Overall, we hope our research will provide patients with IRDS-positive tumors a therapeutic approach that improves outcomes," said Dr. Klein.

Other Cleveland Clinic investigators involved in this research project include Andrew Stephenson, M.D. and Robert Silverman, Ph.D.


'/>"/>

Contact: Stephanie Jansky
JANSKYS@ccf.org
216-636-5869
Cleveland Clinic
Source:Eurekalert

Related medicine news :

1. FastFingerprints Expands in the Cleveland, Ohio Area
2. Clevelanders: Lighting up in a new way
3. NFL Punter Spencer Lanning of the Cleveland Browns Continues Fundraising Effort to Help Kicking For The Dream Fight Ovarian Cancer
4. Medical Experts Gather at Cleveland Clinic Lou Ruvo Center for Brain Health for Annual Silverado Medical Director Conference
5. Cleveland Treatment Center Launches Video Detailing Its Services for Drug, Alcohol Recovery
6. Explorys Selected as One of the Top 25 “Coolest Tech” Companies in Cleveland by Inside Business and Expedient
7. StartUp Health Showcases Digital Health Companies during Cleveland Clinic Medical Innovation Summit
8. Cleveland ENT, Dr. Bert Brown MD, Launches New Website
9. American Brain Tumor Association and Cleveland Clinic Conference Offers Continuing Education to Health Care Professionals
10. Cleveland Clinics preventive breast cancer vaccine development takes step forward
11. Cleveland Clinic research: Most statin-intolerant patients can eventually tolerate statins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 2016 , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment ... Longest Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This ... of the world’s leading providers of cereal and other breakfast foods. Its residents often ...
(Date:6/26/2016)... Clarkston, Michigan (PRWEB) , ... June 26, 2016 ... ... respect to fertility once they have been diagnosed with endometriosis. These women need ... but they also require a comprehensive approach that can help for preservation of ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, ... at Work award to iHire in recognition of their exemplary accomplishments in worksite health ... annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... VEGAS , June 26, 2016 ... to value-based care operating models within the health care ... enable greater financial efficiency , Deloitte offers a ... the key business issues impacting efficient cost optimization: labor ... , These services facilitate better outcomes and better ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
Breaking Medicine Technology: