Navigation Links
Clemson researchers develop sticky nanoparticles to fight heart disease
Date:2/18/2014

CLEMSON, S.C. Clemson University researchers have developed nanoparticles that can deliver drugs targeting damaged arteries, a non-invasive method to fight heart disease.

Heart disease is the leading cause of death in the U.S., according to the Centers for Disease Control and Prevention. One of the standard ways to treat clogged and damaged arteries currently is to implant vascular stents, which hold the vessels open and release such drugs as paclitaxel.

The researchers, led by Clemson bioengineering professor Naren Vyavahare, hope their advanced nanoparticles could be used alongside stents or in lieu of them.

"Healthy arteries have elastic fibers that provide elasticity. They are like rubber bands in the tissue that allow expansion and recoil during blood flow," Vyavahare said. "In most cardiovascular diseases, elastic fibers in arteries get damaged, creating hooks that can be used to target drugs."

The nanoparticles, coated with a sticky protein, latch onto damaged arteries and can deliver a drug to the site in slow release fashion. These nanoparticles can be engineered to deliver an array of drugs to the damaged or clogged artery, a common example being paclitaxel, which inhibits cell division and helps prevent growth of scar tissue that can clog arteries. These particles also have unique surfaces that allow prolonged circulation time, providing more opportunities for these particles to accumulate at the damage site.

"We developed nanoparticles that have antibodies on the surface that attach to diseased sites like Velcro," said Vyavahare. "Interestingly, these newly created nanoparticles only accumulate at the damaged artery, not in the healthy arteries, enabling site-specific drug delivery."

"These nanoparticles can be delivered intravenously to target injured areas and can administer drugs over longer periods of time, thus avoiding repeated surgical interventions at the disease site," said Aditi Sinha, a Clemson graduate student and lead author on a paper soon to be published in journal Nanomedicine: Nanotechnolgy, Biology and Medicine.

The work is a promising step toward new treatments for cardiovascular and other diseases. The research team is testing the nanoparticles to determine the most effective drug dosage for vascular tissue repair. This technology can have variety of applications in other diseases, such as chronic obstructive pulmonary disease, Marfan syndrome and elastic fiber-related disorders, such as aortic aneurysms.


'/>"/>
Contact: Naren Vyavahare
narenv@clemson.edu
864-656-5558
Clemson University
Source:Eurekalert

Related medicine news :

1. Clemson professor awarded nearly $600,000 4-year grant to study language of plants
2. Clemson researcher awarded nearly $245,000 to study automation trust and dependence
3. Clemson researchers collect and reuse enzymes while maintaining bioactivity
4. Clemson bioengineering team wins undergraduate design competition
5. Clemson, GHS create healthcare research powerhouse
6. Clemson, Dartmouth use $1.5M grant to develop mobile health technology
7. Clemson researcher to present at Connecticuts youth concussion conference
8. NIH awards $20 million over 5 years to train next generation of global health researchers
9. Researchers develop a new cell and animal model of inflammatory breast cancer
10. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
11. Researchers Find Gene Mutations That May Be a Key to Autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2017)... (PRWEB) , ... June 24, 2017 , ... Create a feel-good lyric music video in ... footage and sound in the timeline and write in the lyrics to any song. ProLyric ... back out. Each line of the text can be added modularly for optimal control. ProLyric ...
(Date:6/25/2017)... ... , ... With a heatwave currently bearing down on Northern California pushing temperatures to the maximum, ... ready is easy with laser hair removal. , The process of summer waxing and ... when all you want to do is get out, dive in and cool off. There ...
(Date:6/24/2017)... ... June 24, 2017 , ... Dr. Mitchell Mehlman and ... in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable routine and emergency dental ... dentist fit into their patients’ busy lifestyles. Dental365 also gladly work with most ...
(Date:6/23/2017)... Alexandria, VA (PRWEB) , ... June 23, 2017 ... ... short of what is needed and will ultimately do significant harm to people ... care to everyone. , "While it leaves in place the Affordable Care ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Military Officers Association of America (MOAA) ... of Veterans Affairs, retired Marine Col. Thomas G. Bowman. , Bowman currently serves as ... brings an intimacy with the issues and challenges veterans face with the VA. Following ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... 6, 2017  Diplomat Specialty Infusion Group, a brand of Diplomat ... its Iowa location. The ... now features an ISO 7 cleanroom—the standard needed to compound intravenous ... low level of pollutants. "Our ... and better serve our Iowa patients," said ...
(Date:6/1/2017)... , June 1, 2017 Nutriceutical Holdings (NH), ... Recommended Solutions (VRS), and KD Pharma Group have decided ... Holdings by KD Pharma Group. KD Pharma Group will ... option to acquire the entire company. "We ... They are committed to growing the NH companies by ...
(Date:5/26/2017)... DUBLIN , May 26, 2017  Endo International plc ... Campanelli , President and CEO, will represent the Company in ... Global Healthcare Conference on Tuesday, June 13, 2017 at 10:40 ... held at Terranea Resort in Rancho Palos Verdes, ... archive for the event will be available on the Company,s ...
Breaking Medicine Technology: