Navigation Links
Classifying neural circuit dysfunctions using neuroeconomics

Philadelphia, PA, July 24, 2012 The traditional approach to psychiatric diagnosis is based on grouping patients on the basis of symptom clusters. This approach to diagnosis has a number of problems, as symptoms are not necessarily specific to a single diagnosis. Symptoms may vary among patients with a particular diagnosis, and there are no clear diagnostic biomarkers or tests for psychiatry as there are for other areas of medicine.

With this in mind, Steve Chang, along with colleagues from Duke University, introduces a new classification scheme for psychiatric symptoms based on the state of a dysfunctional neural circuit. This is a thought-provoking proposal altering the way science thinks about psychiatric disorders, all of which have been found to have some form of neural circuit dysfunction.

The authors focus on two kinds of functional deficits. Variance-shifted functionality is a condition by which a damaged circuit continues to function, but not at its optimal capacity. State-shifted functionality, on the other hand, is when the function of the circuit is either completely absent or altered in such a way that its output is functionally different.

They discuss these deficits from the perspective of neuroeconomics, an interdisciplinary field that studies the process of decision-making, and related investigations in animals.

"This paper suggests a future in which a cluster of important symptoms for some psychopathology is isolated, classified according to the information-based scheme outlined by Chang et al. and then used to guide the production of a model organism exhibiting deficits in a contributing neural system," commented neuroeconomics expert P. Read Montague at Virginia Tech. "These possibilities are quite exciting not only because of the possible insights into basic mechanisms, but also because of the potentially fruitful interplay with clinical applications."

"Every day, millions of people struggle with mental illness. While great progress has been made in our understanding of mental illnesses, we lack an adequate framework for connecting mental illness with the underlying problems in the brain," saidstudy's first author Steve Chang, postdoctoral fellow at Duke University and member of the Duke Institute for Brain Sciences. "Our understanding of electrical circuits and recent animal studies in the field of neuroeconomics provides novel insights into the ways neural circuits might fail, resulting in specific symptoms. Our hope is that these insights spur new research and ideas in the treatment of mental disorders."

"In an era where psychiatry hopes to draw tighter links between brain biology and diagnosis, it is important to find ways to begin the discussion about how this might be accomplished," commented Dr. John Krystal, Editor of Biological Psychiatry. This study is a step in that direction.

Contact: Rhiannon Bugno

Related medicine news :

1. Neural precursor cells induce cell death in certain brain tumors
2. Charting autisms neural circuitry
3. Growing up as a neural stem cell: The importance of clinging together and then letting go
4. Small neural focus groups predict anti-smoking ad success
5. IBN discovers human neural stem cells with tumor targeting ability
6. Rewiring DNA circuitry could help treat asthma
7. Clinical trial seeks to cure advanced Crohns disease using bone marrow transplant
8. Brain Scans Using New Dye May Predict Alzheimers
9. Using biomarkers to identify and treat schizophrenia
10. Tobacco use more prevalent among African-American adolescents living in public housing communities
11. Technique spots disease using immune cell DNA
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... "When I underwent ... bras were incredibly uncomfortable," said an inventor from Bronx, N.Y. "In order to ... the patent-pending RECOVERY BRA for added comfort and support. The bra is easier ...
(Date:11/25/2015)... ... November 25, 2015 , ... Since its launch ... solutions involving adult stem cell therapies to patients with chronic degenerative medical conditions. ... as a Registered Trademark (RTM). , Organizations are required to hold a registered ...
(Date:11/24/2015)... ... ... Dr. Todd S. Afferica, a noted general dentist in Norcross, GA , ... now uses the BIOLASE WaterLase iPlus 2.0™ in many of his dental procedures. This ... cutting tools, such as the scalpel and high-speed drill, which can both cause patients ...
(Date:11/24/2015)... Angeles, CA (PRWEB) , ... November 24, 2015 , ... ... explored the different restrictions and variables that determine which patients are or are not ... those patients that have a BMI over 40, are more than 100 pounds overweight, ...
(Date:11/24/2015)... City, UT (PRWEB) , ... November 24, 2015 , ... ... Forbes Magazine. For a business, it is critical that the first impression be positive ... business, they are not likely to buy anything or want to return. They will ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 25, 2015 --> ... eine Lizenz für das Patent über eine neue Hepatitis-B-Behandlung, ... ENS-Lyon innehaben, an Enyo Pharma vergeben haben. ... Leben gerufenen und von Edelris gemeinsam mit seinen Partnern ... Behandlungsziel für HBV identifiziert, und es wurden neue Inhaltsstoffe ...
(Date:11/24/2015)... 24, 2015  Natera, Inc. (Nasdaq: ... testing and the analysis of circulating cell-free ... at the 27 th  Annual Piper Jaffray ... p.m. ET.  Matthew Rabinowitz, Ph.D., CEO of Natera, ... activities and financial outlook.  ...
(Date:11/24/2015)... York , 24. November 2015 /PRNewswire/ ... Avery Breathing Pacemaker Systems, ist erfreut, die ... Clinical Consultant bekannt geben zu können. ...   --> Foto - ... (Schweden). Von 1984-1986 war er ...
Breaking Medicine Technology: