Navigation Links
Classifying neural circuit dysfunctions using neuroeconomics
Date:7/24/2012

Philadelphia, PA, July 24, 2012 The traditional approach to psychiatric diagnosis is based on grouping patients on the basis of symptom clusters. This approach to diagnosis has a number of problems, as symptoms are not necessarily specific to a single diagnosis. Symptoms may vary among patients with a particular diagnosis, and there are no clear diagnostic biomarkers or tests for psychiatry as there are for other areas of medicine.

With this in mind, Steve Chang, along with colleagues from Duke University, introduces a new classification scheme for psychiatric symptoms based on the state of a dysfunctional neural circuit. This is a thought-provoking proposal altering the way science thinks about psychiatric disorders, all of which have been found to have some form of neural circuit dysfunction.

The authors focus on two kinds of functional deficits. Variance-shifted functionality is a condition by which a damaged circuit continues to function, but not at its optimal capacity. State-shifted functionality, on the other hand, is when the function of the circuit is either completely absent or altered in such a way that its output is functionally different.

They discuss these deficits from the perspective of neuroeconomics, an interdisciplinary field that studies the process of decision-making, and related investigations in animals.

"This paper suggests a future in which a cluster of important symptoms for some psychopathology is isolated, classified according to the information-based scheme outlined by Chang et al. and then used to guide the production of a model organism exhibiting deficits in a contributing neural system," commented neuroeconomics expert P. Read Montague at Virginia Tech. "These possibilities are quite exciting not only because of the possible insights into basic mechanisms, but also because of the potentially fruitful interplay with clinical applications."

"Every day, millions of people struggle with mental illness. While great progress has been made in our understanding of mental illnesses, we lack an adequate framework for connecting mental illness with the underlying problems in the brain," saidstudy's first author Steve Chang, postdoctoral fellow at Duke University and member of the Duke Institute for Brain Sciences. "Our understanding of electrical circuits and recent animal studies in the field of neuroeconomics provides novel insights into the ways neural circuits might fail, resulting in specific symptoms. Our hope is that these insights spur new research and ideas in the treatment of mental disorders."

"In an era where psychiatry hopes to draw tighter links between brain biology and diagnosis, it is important to find ways to begin the discussion about how this might be accomplished," commented Dr. John Krystal, Editor of Biological Psychiatry. This study is a step in that direction.


'/>"/>
Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Related medicine news :

1. Neural precursor cells induce cell death in certain brain tumors
2. Charting autisms neural circuitry
3. Growing up as a neural stem cell: The importance of clinging together and then letting go
4. Small neural focus groups predict anti-smoking ad success
5. IBN discovers human neural stem cells with tumor targeting ability
6. Rewiring DNA circuitry could help treat asthma
7. Clinical trial seeks to cure advanced Crohns disease using bone marrow transplant
8. Brain Scans Using New Dye May Predict Alzheimers
9. Using biomarkers to identify and treat schizophrenia
10. Tobacco use more prevalent among African-American adolescents living in public housing communities
11. Technique spots disease using immune cell DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... 27, 2017 , ... Silicon Valley Hair Institute, a professional ... upgrade to the company's Yelp listing. Bay Area residents struggling from thinning hair ... Platelet Rich Plasma (PRP) therapy, hair transplantation techniques such as Follicular Unit Extraction ...
(Date:2/26/2017)... (PRWEB) , ... February 26, 2017 , ... ... in 2011 the lab became the world’s first to be ISO/IEC 17025:2005 INAB ... (cat allergen) analysis. , ISO/IEC 17025:2005 is the globally recognised standard that sets ...
(Date:2/26/2017)... KS (PRWEB) , ... February ... ... StaffBridge sets a new technology standard in staffing, scheduling, and reporting for ... monitor, and predict activity throughout the entire staffing process. StaffBridge technology improves ...
(Date:2/25/2017)... ... February 25, 2017 , ... FCPX users now have ... from Pixel Film Studios. With ProSharpen Color users have total control over sharpening amount, ... their color range. With color spectrum tools users can visually see the color range ...
(Date:2/24/2017)... ... February 24, 2017 , ... WHAT: , ... and recognition opportunities as well as advocacy for the state and region‘s technology ... February 23. The Council's Innovation Forecast event highlights innovation throughout the region ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... YORK , Feb. 23, 2017 Report analyzes ... report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... and forecasts are provided for the period 2015 through 2022. ... Market data and analytics are derived from primary and secondary ...
(Date:2/24/2017)... from Pharma To Market Pty Ltd and Ador Consulting Pte Ltd ... founding of Pharma To Market Pte Ltd, based in ... announce their expansion into Asia with the ... company are delighted to appoint Joelle Chia , former owner ... based entity. Joelle brings with her an extensive business network ...
(Date:2/24/2017)... , Feb. 23, 2017  The particle counters ... by 2021 from USD 275.9 million in 2016, ... the full report: http://www.reportlinker.com/p04718602-summary/view-report.html ... on pharmaceutical R&D, and growth in manufacturing industries ... market growth for particle counters. On the other ...
Breaking Medicine Technology: