Navigation Links
Clarifying the effect of stem cell therapy on cancer
Date:4/28/2013

Injection of human stem cells into mice with tumors slowed down tumor growth, finds research published in BioMed Central's open access journal Stem Cell Research & Therapy. Human mesenchymal stem cells (MSC), isolated from bone marrow, caused changes in blood vessels supplying the tumor, and it is this modification of blood supply which seems to impact tumor growth.

The use of stem cells in treating cancer has been controversial, with some studies finding that stem cells force tumors to enter programmed cell death. However other studies find that stem cells actually promote tumor growth by inducing infiltration of new blood vessels. In attempting to sort out this puzzle researchers from INSERM groups at Universit Joseph Fourier in collaboration with CHU de Grenoble investigated the impact of MSC on already established subcutaneous or lung metastasis in mice.

For both the subcutaneous and lung tumors, injection of MSC reduced cell division, consequently slowing the rate of tumor growth. Part of the mode of action of stem cells therefore appears to be due to with angiogenesis, but the mechanism behind this is still unclear.

Claire Rome who led this study explained, "We found that MSC altered vasculature inside the tumor - although new blood vessels were generated, overall they were longer and fewer than in untreated tumors. This could be restricting the oxygen and nutrients to the tumor, limiting cell division." She continued, "Our study confirms others which propose that stem cells, in particular MSC, might be one way forwards in treating cancer."

Commenting on this study Celia Gomes, from the University of Coimbra, said, "One of the interesting questions this study raises is when MSC promote tumor growth and when they restrict it. The answer seems to be timing this study looks at already established tumors, while others, which find that MSC increase growth, tend to be investigating new tumors. This is a first step in the path to identifying exactly which patients might benefit from stem cell therapy and who will not."


'/>"/>

Contact: Hilary Glover
hilary.glover@biomedcentral.com
44-020-319-22370
BioMed Central
Source:Eurekalert

Related medicine news :

1. Penn pilot study: Group of Bradford Co, Pa. residents concerned about health effects of hydrofracking
2. New Research Shows Programs like Recovery Associates Offer the Most Effective Type of Treatment for Drug and Alcohol Addiction
3. Stanford study examines cost-effectiveness of helicopter transport of trauma victims
4. Porn Use Has Small Effect on Sexual Behavior, Study Finds
5. Research finds targeted screening for hepatitis C is cost-effective
6. In Light of Alleged Deceptive Marketing Claims Made by Drug Makers, Parker Waichman LLP Addresses Issues Allegedly Related to the Safety and Effectiveness of Plavix
7. Popular Cinnamon Stunt Can Have Serious Lung Effects
8. NeoGraft Automated FUE Hair Restoration Offers a Safe and Effective Way to Naturally Restore Eyebrow Hair Loss
9. Intensity modulated radiotherapy reduces side effects in patients with early breast cancer
10. New ASTRO white paper recommends best practices to improve safety and effectiveness of IGRT
11. Experts examine Mediterranean diets health effects for older adults
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... The Bank of America Charitable Foundation has ... help provide veterans a pathway to employment and successful careers in healthcare. On Wednesday, ... Nick Hallack, President and CEO of Medisend, parent organization and home of the General ...
(Date:5/25/2016)... ... May 25, 2016 , ... New studies published today ... workers across 15 states. The outcomes examined in these studies include recovery of ... and satisfaction with medical care. , “The goal of the studies is to ...
(Date:5/25/2016)... ... 2016 , ... Today Omega Institute, a leading destination for yoga education in ... opportunities in the growing field of yoga therapy . Yoga therapy adapts ... specific health issues—including injuries, illnesses, and temporary or chronic health conditions. , “Yoga therapy ...
(Date:5/25/2016)... Washington, D.C (PRWEB) , ... May 25, 2016 ... ... of family planning services and products in the developing world, is pleased to ... couples, helped prevent over 5 million unwanted pregnancies, almost 14,000 maternal deaths and ...
(Date:5/25/2016)... ... May 25, 2016 , ... ... supporting the real time adjudication of medical service claims by Pharmacy Benefit Managers ... current medical claims management software. The TransactRx Cross Benefit Clearinghouse receives standard professional ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... Non-invasive diagnostic test realizes the ... ,Technology to be presented at Yissum’s booth, at IATI-BIOMED ... Company of the Hebrew University of Jerusalem announced ... Aurum Ventures MKI, the technology investment arm of Morris ... approach for early detection of multiple diseases by analyzing ...
(Date:5/23/2016)... -- Gamida Cell, a leader in cellular ... orphan genetic diseases, announced today it has been awarded ... Israel Innovation Authority (formerly the Office of the Chief ... The mission of the Israel Innovation Authority is to ... and technology, while stimulating economic growth. The ...
(Date:5/23/2016)... STAMFORD, Conn. , May 23, 2016 /PRNewswire/ ... Company has entered into an agreement with Egalet ... various patent claims. As part of the agreement ... rights, and will enable all three companies to ... abuse-deterrent properties. "This agreement reflects the ...
Breaking Medicine Technology: