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City of Hope Researchers Present Data on more than 30 Studies During American Society of Hematology Meeting Dec. 5 to 8 in New Orleans
Date:12/7/2009

f="http://www.cityofhope.org/directory/people/wong-lennie/Pages/default.aspx" onclick="linkClick( this.href );" target="_blank" title="Lennie Wong">Lennie Wong, Ph.D., associate research professor in the Department of Population Sciences at City of Hope. In this three-year study, one of the longest of its kind, lead author Wong and her City of Hope colleagues sought to verify whether there is an increase in deficit and identify which patients may be susceptible. “We wanted to examine longitudinal trends after patients received their transplants to see whether they were getting worse or better, and also to find risk factors to identify patients who may do worse than others. Few studies have systematically assessed the impact of cognitive changes on the ability to return to work -- a practical indicator that patients are recovering and resuming their lives.
    
The study followed patients who received either allogeneic transplants (blood stem cells from a healthy donor) or autologous transplants, which use a patient’s own, purified blood stem cells. Before and after transplants, patients underwent extensive tests to measure neurocognitive function. Researchers discovered that overall, hematopoietic cell transplantation does not have a major impact on the neurocognitive functioning of the recipients. Allogeneic transplant patients seem to do worse than autologous patients and are more affected by treatments in terms of neurocognitive function, including memory loss, information processing and “executive functioning” (the ability to multitask). Researchers also found that the ability to return to work is affected by impairment in immediate memory and verbal speed. “Targeted surveillance and
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City of Hope Researchers Present Data on more than 30 Studies During American Society of Hematology Meeting Dec. 5 to 8 in New Orleans
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