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City of Hope Researchers Present Data on more than 30 Studies During American Society of Hematology Meeting Dec. 5 to 8 in New Orleans
Date:12/7/2009

Research at City of Hope">Division of Outcomes Research at City of Hope, and lead author of the study, explored why certain patients are more susceptible to t-MDS/AML by looking at key groups of genes involved with DNA repair, drug metabolism and apoptosis. Apoptosis is a sort of programmed death most cells undergo when they are damaged or faulty.

“Cancer treatments often target DNA damage and repair and apoptosis pathways to eradicate malignant cells,” said Ding. “We found that patients’ ability to repair their DNA, metabolize drugs and undergo apoptosis affected their risk of getting t-MDS/AML,” she added. The team also found that patients with a genetic susceptibility to developing AML without therapy had an increased risk of t-MDS/AML.

“The study has helped us understand and predict who might be at risk for developing this complication, so we can gear our interventions toward them accordingly,” said Smita Bhatia, M.D., M.P.H., director, Center for Cancer Survivorship at City of Hope, and senior author on the study.

“Neurocognitive Function and its Impact on Return to Work in Patients Treated with Hematopoietic Cell Transplantation”
ASH Abstract # 521 (Oral)

Patients undergoing hematopoietic stem cell transplants are often at risk for neurocognitive impairments such as memory loss caused by conditioning treatments like total body irradiation and drugs used to prevent graft versus host disease.

“We heard anecdotal stories from patients about their neurocognitive losses following treatment,” said '/>"/>

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City of Hope Researchers Present Data on more than 30 Studies During American Society of Hematology Meeting Dec. 5 to 8 in New Orleans
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