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City of Hope Researchers Present Data on more than 30 Studies During American Society of Hematology Meeting Dec. 5 to 8 in New Orleans
Date:12/7/2009

ofhope.org/directory/people/bhatia-ravi/Pages/default.aspx" onclick="linkClick( this.href );" target="_blank" title="Ravi Bhatia">Ravi Bhatia, M.D., director, Division of Stem Cell and Leukemia Research at City of Hope, and senior author on the study. Their research has led to a clinical trial, now in progress. (See Abstract #2194: “A Phase 1 Study of the HDAC Inhibitor LBH589 in Combination with Imatinib for Patients with CML in Cytogenetic Remission with Residual Disease Detectable by Q-PCR.”)

“The ultimate aim would be to give this combination therapy to patients who would go from having temporary remission with residual cells to being completely cured of leukemia,” said Bhatia. Potentially, this combination of drugs also may be successfully applied to other leukemias and cancers, including myelodsyplastic syndrome (MDS), acute myeloid leukemia (AML) and perhaps breast and colon cancers.

“Genetic Susceptibility to Therapy-Related Leukemia (t-MDS/AML) After Hodgkin Lymphoma (HL) or Non-Hodgkin Lymphoma (NHL)”
ASH Abstract #199 (Oral)

Treatments for lymphoma can cure patients of their disease but also can lead some to develop acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), the leading cause of non-relapse death. Currently there is no reliable method to identify which patients are most at risk of developing this therapy-related disease, known as t-MDS/AML, so that preventive steps can be taken. In partnership with her City of Hope colleagues, molecular epidemiologist Yan Ding, Ph.D., M.S.,

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City of Hope Researchers Present Data on more than 30 Studies During American Society of Hematology Meeting Dec. 5 to 8 in New Orleans
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