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City of Hope Researchers Present Data on more than 30 Studies During American Society of Hematology Meeting Dec. 5 to 8 in New Orleans
Date:12/7/2009

Topics presented range from targeting dormant cancer stem cells to assessing neurocognitive side effects after bone marrow transplants

Duarte, Calif. (Vocus) December 7, 2009 -- City of Hope researchers will present data from more than 30 studies during the 2009 American Society of Hematology (ASH) meeting Dec. 5 to 8 in New Orleans, focusing on such topics as a new drug combination to target dormant chronic myelogenous leukemia (CML) stem cells, lymphoma patients’ genetic susceptibility to therapy-related leukemia, and neurocognitive impairments after bone marrow transplants.

Research highlights include:

“Effective targeting of Quiescent CML Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate”
ASH Abstract #190 (Oral)

Imatinib mesylate (Gleevec) has become known as a wonder drug that has dramatically improved the treatment of CML, yet patients can relapse because the disease often lurks in the “quiescent” or dormant stem cells. To understand how cells resist Gleevec treatment and find ways to better target these residual stem cells, clinical research fellow and lead author Bin Zhang, Ph.D., and her City of Hope colleagues conducted a series of experiments on tumor tissue samples from patients. Research team members believe they are the first to demonstrate that histone deacetylase (HDAC) inhibitors in combination with Gleevec can destroy the hidden reservoir of treatment-resistant CML stem cells.

“We’ve shown that these drugs in combination with Gleevec are very effective in killing CML stem cells – including the dormant ones,” said

Source: PRWeb
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City of Hope Researchers Present Data on more than 30 Studies During American Society of Hematology Meeting Dec. 5 to 8 in New Orleans
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