Navigation Links
Circumcision reduces the risk of HIV infection in heterosexual US men

A new U.S. study has found that being circumcised significantly reduced the risk of HIV infection in heterosexual African American men known to have been exposed to the virus. The findings complement those of recently reported clinical trials in Africa, where interventional use of adult male circumcision similarly reduced the risk of HIV infection in heterosexual men. The findings of the new study, along with similar results from other studies, suggest that circumcision may protect other heterosexual males in the U.S. The promising new findings are reported in the January 1 issue of The Journal of Infectious Diseases, now available online.

Lee Warner, PhD, MPH, and colleagues at the Centers for Disease Control and Prevention (CDC) and the Johns Hopkins University School of Medicine studied the records of more than 26,000 African American men who had had HIV testing during visits to two Baltimore, Maryland, STD clinics from 1993 to 2000. The subjects selected for the study said that they did not inject drugs and had sex only with women. Their visits to the clinics were classified as involving known HIV exposure if there had been a recent notification of such exposure by a sex partner or by a clinic's disease intervention specialists; clinic visits for other reasons were classified as involving unknown HIV exposure. By these criteria, the investigators found 394 visits with known exposure and 40,177 visits with unknown exposure.

In visits by men with known HIV exposure, being circumcised was associated with a 51 percent reduction in HIV prevalence (10.2 percent of circumcised men vs. 22.0 percent of uncircumcised men). In contrast, HIV prevalence did not significantly differ in circumcised compared to uncircumcised men with unknown HIV exposure (2.5 percent vs 3.3 percent).

The investigators noted that three other U.S.-based studies had previously suggested that circumcision may be associated with reduced HIV risk, but the findings were limited by small sample size or extremely low HIV prevalence and did not achieve statistical significance. Indeed, HIV prevalence in the United States is very low (about 0.4 percent), and the proportion of circumcised adult males is high (about 80 percent), which could make it hard for conventional observational studies (i.e., studies that are not clinical trials) to discern whether circumcision actually has a protective effect. By focusing on patients who had documented exposure to an HIV-infected female partner, the current study was able to reveal that there was indeed a protective effect. This approach, the investigators said, "represents a significant methodological advancement over most previous observational studies."

In a separate editorial on the topic, Ronald H. Gray, MBBS, MSc, of Johns Hopkins University, pointed out that circumcision may be especially important for minority U.S. populations, including Hispanic as well as African American mensubgroups most at risk for HIV infection. He also noted that the American Academy of Pediatrics has thus far not recommended routine neonatal circumcision, and that Medicaid does not cover the procedure. "It is to be hoped," he said, "that the paper by Warner et al., in conjunction with the weight of evidence from international studies, will persuade the Academy to recognize the public health importance of this surgery for prevention of HIV in minority U.S. populations."

Fast Facts:

  • Recently reported clinical trials in Africa have shown that interventional use of adult male circumcision reduced the risk of HIV infection in heterosexual men.
  • The current U.S. study was able to show that circumcision significantly protected heterosexual African American men. It did so by focusing on subjects who had documented exposure to an HIV-infected female partner.


Contact: Steve Baragona
Infectious Diseases Society of America

Related medicine news :

1. Is infant male circumcision an abuse of the rights of the child?
2. Circumcision doesnt reduce sexual satisfaction and performance, says study of 4,500 men
3. Study finds circumcision safe in both HIV-infected and HIV-uninfected men
4. Role of Circumcision in Reducing HIV Risk Still Unclear
5. US$18.5 million grant makes male circumcision a top-tier HIV prevention strategy
6. New study: Pine bark reduces perimenopausal symptoms
7. Different method of evaluating the urinary tract system reduces radiation dose
8. Saline Reduces Mortality for Brain Injury Patients
9. New study: Pine bark extract reduces ADHD symptoms in children
10. Radiation therapy technique reduces length of prostate cancer treatment
11. Radiation therapy technique reduces length of prostate cancer treatment
Post Your Comments:
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... first high-tech foam roller with 11 hours of vibrating power. Tested by Olympic ... recovery time and increase athletic performance. , Mark's background in sporting equipment and ...
(Date:10/13/2015)... , ... October 13, 2015 , ... Vision Group Holdings, ... of San Diego, California. With brands including The LASIK Vision Institute and TLC Laser ... it the nationwide leader in laser vision correction. , Global Laser Vision will continue ...
(Date:10/13/2015)... PA (PRWEB) , ... October 13, 2015 , ... "My ... digging his fists into his infected cheeks," said an inventor from Platteville, Colo. "I ... their skin problems." , He developed the UNTOUCHABLE to prevent a child from rubbing ...
(Date:10/13/2015)... ... October 13, 2015 , ... HealthAware , headquartered ... Patient Engagement Summit . HealthAware is a technology company focused on the ... interventions via mobile devices that provide a framework for the development of healthy ...
(Date:10/13/2015)... (PRWEB) , ... October 13, 2015 , ... ... workflow solutions, announced today their sponsorship of the Microsoft Dynamics AXUG, GPUG and ... AXUG Summit, GPUG Summit and NAVUG Summit are independent user conferences designed and ...
Breaking Medicine News(10 mins):
(Date:10/13/2015)... 2015  ContraVir Pharmaceuticals, Inc. (Nasdaq: CTRV ... focused on the development and commercialization of targeted ... previously announced underwritten public offering of 5,000,000 shares ... up to 3,000,000 shares of the Company,s common ... public of $3.00. The shares of common stock ...
(Date:10/13/2015)... , Oct. 13, 2015  Human Longevity, Inc. (HLI), ... of medicine, announced today the launch of the company,s ... that has the potential to transform healthcare. The inaugural ... CA , at HLI,s headquarters facility. More Health ... other US and International cities. ...
(Date:10/13/2015)... 13, 2015  Measurement in accountable care programs ... financial incentives, but gaps in measurement can result ... health systems. A new, peer-reviewed study published ... explores measurement gaps for high-priority conditions ... --> --> "These ...
Breaking Medicine Technology: