Navigation Links
Circulating tumor cells can reveal genetic signature of dangerous lung cancers
Date:7/2/2008

Massachusetts General Hospital (MGH) investigators have shown that an MGH-developed, microchip-based device that detects and analyzes tumor cells in the bloodstream can be used to determine the genetic signature of lung tumors, allowing identification of those appropriate for targeted treatment and monitoring genetic changes that occur during therapy. A pilot study of the device called the CTC-chip will appear in the July 24 New England Journal of Medicine and is receiving early online release.

"The CTC-chip opens up a whole new field of studying tumors in real time," says Daniel Haber, MD, director of the MGH Cancer Center and the study's senior author. "When the device is ready for larger clinical trials, it should give us new options for measuring treatment response, defining prognostic and predictive measures, and studying the biology of blood-borne metastasis, which is the primary method by which cancer spreads and becomes lethal."

CTCs or circulating tumor cells are living solid-tumor cells found at extremely low levels in the bloodstream. Until the development of the CTC-chip by researchers from the MGH Cancer Center and BioMEMS (BioMicroElectroMechanical Systems) Resource Center, it was not possible to get information from CTCs that would be useful for clinical decision-making. The current study was designed to find whether the device could go beyond detecting CTCs to helping analyze the genetic mutations that can make a tumor sensitive to treatment with targeted therapy drugs.

The researchers tested blood samples from patients with non-small-cell lung cancer (NSCLC), the leading cause of cancer death in the U.S. In 2004, MGH researchers and a team from Dana-Farber Cancer Institute both discovered that mutations in a protein called EGFR determine whether NSCLC tumors respond to a group of drugs called TKIs, which includes Iressa and Tarceva. Although the response of sensitive tumors to those drugs can be swift
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Circulating Tumor Cells Reveal Insights Into Lung Cancers
2. High circulating D-dimers are associated with presence of ascites
3. FDA Clears Cellsearch(TM) Circulating Tumor Cell Test for Monitoring Metastatic Prostate Cancer Patients
4. Circulating fats kill transplanted pancreas cells, study shows
5. Researchers identify promising cancer drug target in prostate tumors
6. Identification of 5 genes involved in the metastasis of breast tumors to the lung
7. New cancer treatment targets both tumor cells and blood vessels
8. Wavelets crunch through doctors day long struggle to diagnose brain tumors
9. A rare association: Non-islet cell tumor hypoglycemia
10. A new weapon for attacking tumor invasion and metastasis
11. Ability to track stem cells in tumors could advance cancer treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... (PRWEB) May 29, 2015 To compile ... research, choosing systems that have several awards for clinical ... on what systems stood out to them in terms ... inclusion as well. , The 50 Great Health Systems ... Adventist Health System (Altamonte Springs, Fla.) , Advocate Health ...
(Date:5/29/2015)... 29, 2015 Intermountain Healthcare ... with Stratus Video Interpreting for ... better communication and timely care for patients ... loss. Stratus’ video remote interpreting (VRI) services ... staff to quickly access qualified medical interpretation ...
(Date:5/29/2015)... NY (PRWEB) May 29, 2015 The ... as well as a number of specific concerns within, ... stigma reduction and mental health in the workplace. We ... mental health. The campaign also brings special focus to ... individuals to speak up and seek help from healthcare ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 Oaksterdam University, the first ... this time to host its popular and highly demanded ... and 15 from 10:00 am to 5:30 pm each day. Certification ... Job Fair will be held on June 14 from 12:00 ... will be held at the Plaza Hotel & Casino in downtown ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 Healthpointe clinics ... injuries with the help of their licensed clinical psychologist, ... brain injuries can lead to an extensive array of ... effects can arise at any time after a traumatic ... caused by any bump or jolt to the head ...
Breaking Medicine News(10 mins):Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 2Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 3Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 2Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 3Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 4Health News:Mediaplanet Brings Activism to Those Living with Mental Illness in Bew “Mental Health Awareness” Campaign 2Health News:Oaksterdam University to Host Educational Cannabis Seminars and Job Fair in Las Vegas June 12 to 15; Training For Those Wanting To Work in Legal Cannabis Industry 2Health News:Oaksterdam University to Host Educational Cannabis Seminars and Job Fair in Las Vegas June 12 to 15; Training For Those Wanting To Work in Legal Cannabis Industry 3Health News:Healthpointe’s Los Angeles County Clinics Are Now Offering Treatment for Mild Traumatic Brain Injuries 2
... robust, flexible and easy-to-use search platform to enable healthcare ... , PITTSBURGH, June 10 Vivisimo ( ... announced that HCPro, a provider of education and information ... Vivisimo,s award-winning Velocity platform to power ...
... BALTIMORE, June 10 Physicians Practice and the Pocono ... physicians and their staff more time to devote to ... designed to help doctors in and around Monroe County, ... managing a busy practice. Through this new alliance, Pocono ...
... Could Include Millions More , , WASHINGTON, June 10 ... seven -- will receive a smaller Social Security check next year, ... Millions of other seniors who do not have their Medicare premiums ... dollars leftover next year. , , These seniors will ...
... Aspen Institute Host Forum Focusing On ,Achieving Recovery Through Discovery, , , WASHINGTON, June ... medical innovation is at risk., ... among 40 countries and regions in innovation and, ... of progress, made over the ...
... , Bracco,s Cardiogen-82(R) Enables Cardiologists to ... , OTTAWA, June 10 /PRNewswire-FirstCall/ - MDS Nordion, a ... that it has commenced the manufacture of CardioGen-82(R) (Rubidium-82 ... one of the world,s leading companies in the imaging ...
... Transdel,s Anti-Cellulite Cosmeceutical Product , , LA ... (OTC Bulletin Board: TDLP) and JH Direct, LLC ... Direct with the exclusive worldwide rights to Transdel,s ... delivery system technology, Transdel(TM). The licensing agreement ...
Cached Medicine News:Health News:HCPro Selects Vivisimo Velocity to Launch MedicareFind.com 2Health News:HCPro Selects Vivisimo Velocity to Launch MedicareFind.com 3Health News:Physicians Practice and Pocono Medical Center to Improve Patient Care in Monroe County, Pennsylvania 2Health News:Physicians Practice and Pocono Medical Center to Improve Patient Care in Monroe County, Pennsylvania 3Health News:Physicians Practice and Pocono Medical Center to Improve Patient Care in Monroe County, Pennsylvania 4Health News:One in Seven Seniors Faces Social Security Check Cuts in 2010 2Health News:'Best and Brightest Forum on Medical Innovation' Brings Senator Arlen Specter, U.S. Representative Anna Eshoo, and Innovation Leaders Together in Washington, D.C., This Week 2Health News:'Best and Brightest Forum on Medical Innovation' Brings Senator Arlen Specter, U.S. Representative Anna Eshoo, and Innovation Leaders Together in Washington, D.C., This Week 3Health News:MDS Nordion Begins to Manufacture Cardiac Imaging Agent 2Health News:MDS Nordion Begins to Manufacture Cardiac Imaging Agent 3Health News:Transdel Pharmaceuticals Enters Into License Agreement with JH Direct, LLC for Cosmeceutical Product 2Health News:Transdel Pharmaceuticals Enters Into License Agreement with JH Direct, LLC for Cosmeceutical Product 3Health News:Transdel Pharmaceuticals Enters Into License Agreement with JH Direct, LLC for Cosmeceutical Product 4
(Date:5/29/2015)... Fla. , May 29, 2015  Excite Medical ... in 2007.  Over the years, Excite Medical, under the ... be an enduring company, with a solid track record ... and growing client and distributor base.  ... success of Excite Medical has been possible, in large ...
(Date:5/29/2015)... A six-hour certification program on "How to ... Cannabis World Congress & Business Exposition (CWCBExpo) at ... .  Taking place on Wednesday, June 17 th this ... the leading event on the East Coast for the legalized ... Leaf University, the first cannabis university to be approved, regulated ...
(Date:5/29/2015)... Eli Lilly and Company (NYSE: LLY ... Healthcare Conference on Tuesday, June 9, 2015. Jeffrey ... Health, will participate in a fireside chat at 2:20 ... audio webcast will be available on the "Webcasts & ... . A replay of the fireside chat will be ...
Breaking Medicine Technology:Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 3Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 4Lilly to Participate in Goldman Sachs Global Healthcare Conference 2
... Reportlinker.com announces that a new market research report ... Chinese Markets for Bladder Cancer Treatment Drugs ... , China,s demand for ... fast pace in the past decade. In the ...
... TUSTIN, Calif., Nov. 3 Peregrine Pharmaceuticals, Inc. (Nasdaq: ... Company received notice from the NASDAQ Market Listing Qualifications Department ... price rule for the continued listing of its common stock ... Marketplace Rule 5550(a)(2). , Pursuant to NASDAQ,s rules, Peregrine was ...
Cached Medicine Technology:Reportlinker Adds Chinese Markets for Bladder Cancer Treatment Drugs 2Reportlinker Adds Chinese Markets for Bladder Cancer Treatment Drugs 3Reportlinker Adds Chinese Markets for Bladder Cancer Treatment Drugs 4Reportlinker Adds Chinese Markets for Bladder Cancer Treatment Drugs 5Peregrine Pharmaceuticals Regains Full Compliance With Nasdaq Continued Listing Requirements 2
... helps provide protection to the exposed airway of ... lightweight making it ideal for active young children ... of heat and moisture recovery, it ensures patient ... and filters have ISO standard tapered ends to ...
... Thermovent® T helps provide protection to the exposed ... and extremely lightweight making it ideal for active ... high rate of heat and moisture recovery, it ... ,All HMEs and filters have ISO standard tapered ...
... T helps provide protection to the exposed airway ... extremely lightweight making it ideal for active young ... rate of heat and moisture recovery, it ensures ... HMEs and filters have ISO standard tapered ends ...
For use with: , pulmonary function testing , nebulizer compressors , humidifiers , concentrators , proximal pressure lines ...
Medicine Products: