Navigation Links
Circulating tumor cells can provide 'real-time' information on patient's current disease state
Date:9/28/2010

DENVER Circulating tumor cells (CTCs) may be a promising alternative, noninvasive source of tumor materials for biomarker assessment, according to data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development.

"The basic idea is that CTCs can provide real-time information about a patient's current disease state, acting as a 'liquid biopsy,'" said Siminder Kaur Atwal, Ph.D., senior research associate at Genentech. "They are much less invasive than tumor biopsies because they can be detected from a blood draw and don't require surgical intervention."

For this study, Atwal and colleagues compared the CTC capture efficiency of the Food and Drug Administration-approved CellSearch platform with two biochip platforms, using tumor cell lines spiked into whole blood. They tried to detect epidermal growth factor receptor (EGFR) protein expression in CTCs from patients with lung cancer and HER2 expression or amplification in CTCs in patients with metastatic breast cancer.

Under the tested conditions, CellSearch and the newer biochip platforms offered similar efficiency. Further, capture efficiency was dependent on EpCAM (epithelial cell adhesion molecule) expression.

"This may be a limitation in capturing CTCs from certain tumor types, notably triple-negative breast cancers," Atwal said.

Captured CTCs were amenable to biomarker analyses such as HER2 status, qRT-PCR for breast cancer subtype markers, KRAS mutation detection and EGFR staining by immunofluorescence, the researchers found. In patients with HER2-positive breast cancer, HER2 status in CTCs and tumor tissue generally correlated; however, in one patient subset, HER2 status changed from the primary tumor at diagnosis. This finding indicates that in some cases, CTCs may offer a real-time view of a patient's biomarker status that is different from diagnostic tissue, Atwal said.

Some improvements are
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Revisiting the need to detect circulating tumor cells
2. Improved device provides more rapid, comprehensive analysis of circulating tumor cells
3. Survival in metastatic breast cancer directly linked to circulating tumor cells
4. Circulating tumor cells correlate with poorer survival in pancreatic cancer patients
5. Researchers discover new way to kill pediatric brain tumors
6. Researchers create drug to keep tumor growth switched off
7. Fluorescent probes light up cancerous tumors
8. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
9. Drug for advanced kidney cancer shrinks tumors prior to surgery
10. Researchers discover second protective role for tumor-suppressor
11. Personalizing cancer: Creating biomarkers from tumor DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... (PRWEB) September 22, 2014 The struggles ... English proficiency (LEP) patients has been well-documented—reportedly, language barriers ... repeat visits to the emergency room and an increased ... , At Sanford Health, the largest medical facility ... a rising LEP population necessitated the need for ...
(Date:9/22/2014)... York / Westchester County, NY (PRWEB) September 22, 2014 ... Surgery (NYGPS) has joined the Department of Surgery at ... newly named Mount Sinai Doctors New York Group for ... the lower Hudson Valley access to a team of ... surgery techniques. Additionally, C. Andrew Salzberg, MD, who ...
(Date:9/22/2014)... ARBOR, Mich. Almost three-quarters (74%) of parents ... and more than one-quarter (28%) have used those ... their children, according to U-M research published today ... of Michigan,s C.S. Mott Children,s Hospital National Poll ... how online ratings of physicians influenced their choices ...
(Date:9/22/2014)... beats out a very familiar "lub-dub" pattern that speeds ... decreases, the pattern itself isn,t as regular as you ... heartbeats can vary even at a "constant" heart rateand ... , Reduced heart rate variability (HRV) has been ... such as congestive heart failure and inflammation. For athletes, ...
(Date:9/22/2014)... a type of flavonoid found in hops and beer, ... cognitive function in young mice, but not in older ... Behavioral Brain Research by scientists from the Linus ... State University. It,s another step toward understanding, and ultimately ... in many mammalian species, including humans. , Flavonoids are ...
Breaking Medicine News(10 mins):Health News:Healthcare Cost Savings Case Study:Stratus Video Interpreting Assists Sanford Health System in Accommodating Increasing LEP Population,Saves a Predicted $100,000 Per Year 2Health News:Healthcare Cost Savings Case Study:Stratus Video Interpreting Assists Sanford Health System in Accommodating Increasing LEP Population,Saves a Predicted $100,000 Per Year 3Health News:Healthcare Cost Savings Case Study:Stratus Video Interpreting Assists Sanford Health System in Accommodating Increasing LEP Population,Saves a Predicted $100,000 Per Year 4Health News:The New York Group for Plastic Surgery Joins Mount Sinai Doctors 2Health News:The New York Group for Plastic Surgery Joins Mount Sinai Doctors 3Health News:Online ratings influence parents' choices of physicians for their children 2Health News:Variability keeps the body in balance 2Health News:Variability keeps the body in balance 3Health News:Variability keeps the body in balance 4Health News:Compound from hops aids cognitive function in young animals 2
... scientists at the Johns Hopkins School of Public Health has ... called for urgent research into the impact of soya on ... in soya can damage the male reproductive organs. Though there ... on humans, its effects on rats were so severe that// ...
... a study published in the British Medical Journal, older people ... The researchers from Cambridge, UK, identified a group of 2,686 ... sent either one capsule of Vitamin D3 or a placebo ... to provide them with information on bone fractures// and any ...
... prevalent diseases in our society with more than five million ... According to a major study in the UK, in which ... across the UK, asthma sufferers are dying needlessly because they ... compared levels of asthma control and the need and number ...
... reached epidemic proportions the world over, with India being ... the many serious diseases that diabetics can be affected ... deterioration of nerves in the body. A diabetic patient ... one or more amputations. It has been found that ...
... appetite control, called ghrelin, has been identified by researchers ... demonstrated the effect of the hormone on the brain ... neurons in the hypothalamus involved in weight regulation. Ghrelin ... ability to stimulate feeding when introduced to specialized weight ...
... skin cancer and it has been shown through previous research ... whose UV rays cause damage to DNA that triggers cancer. ... more prone than others to melanoma. Researchers have now found ... with melanoma that those with fair skin// have lowered DNA ...
Cached Medicine News:Health News:Scientists locate key hormone involved in appetite control 2
(Date:9/22/2014)... 22, 2014 A study on ... recently added to Transparency Market Research,s database of market ... Analysis, Size, Share & Forecast (2011 - 2017)", the ... US$ 3.9 billion in 2011, would observe growth at ... period of the report), and end-up valuing US$ 4.8 ...
(Date:9/22/2014)... Children,s National Health System has announced ... 5 p.m. EDT for its "Make Your Medical ... continued strong interest from inventors.  Two ... to the winning presentations at the Sheikh Zayed Institute ... Children,s National in October. For competition details,  click ...
(Date:9/22/2014)... 2014 Research and Markets has ... Novel Hypercholesterolemia Drugs" report to their offering. ... high cholesterol burden despite the presence of many cholesterol-lowering ... options, statins have been ubiquitously prescribed over the last ... LDL cholesterol (LDLC) is the cornerstone of assessing heart ...
Breaking Medicine Technology:Global Magnetic Resonance Imaging (MRI) Market Worth US $4.8 Billion by 2017: Transparency Market Research 2Global Magnetic Resonance Imaging (MRI) Market Worth US $4.8 Billion by 2017: Transparency Market Research 3Global Magnetic Resonance Imaging (MRI) Market Worth US $4.8 Billion by 2017: Transparency Market Research 4Calling all medical innovators: Submit your pediatric medical device pitch for Children's National competition by Sept. 29 2Calling all medical innovators: Submit your pediatric medical device pitch for Children's National competition by Sept. 29 3PCSK9 and Other Novel Hypercholesterolemia Drugs 2PCSK9 and Other Novel Hypercholesterolemia Drugs 3
... One out of three U.S. adults plan to skip ... Medical telephone poll. Against that backdrop, two top clinical leaders ... American public that influenza season can be a deadly time ... asthma or COPD (Chronic Obstructive Pulmonary Disease). Such patients need ...
... One week after a CDC report outlined the devastating ... which causes 8,000 U.S. deaths and costs billions of ... of patients, families, advocates, physicians and scientists, last night ... discoveries and unique contributions to the field of dermatology ...
Cached Medicine Technology:Poll: One Out of Three U.S. Adults Not Planning to Get Flu Shot This Year 2American Skin Association Honors Leading Physicians and Scientists; Journalist Deborah Norville 2American Skin Association Honors Leading Physicians and Scientists; Journalist Deborah Norville 3
The MACS VA_500 (variable atmosphere) is primarily for the study and isolation of microaerophilic organisms,including Campylobacter spp,Helicobacter pylori and other similarly fastdious organisms....
... an electrical power supply, MERKUR offers a broad ... a gas spring for ease of operation. For ... a foot pedal hydraulic system. Thanks to its ... anytime in a highly mobile and flexible manner. ...
... table MARS Enduro is the ideal ... are required before, during or directly ... motorised longitudinal adjustment and the filigreed ... conditions in examination, induction and operating ...
... Top Rotation provides uncommon bi-directional flexibility, ... Hercules 6700B eliminates any conflicts between ... while providing ample leg room for ... procedures. Removable back and leg sections ...
Medicine Products: