Navigation Links
Circulating tumor cells can provide 'real-time' information on patient's current disease state
Date:9/28/2010

DENVER Circulating tumor cells (CTCs) may be a promising alternative, noninvasive source of tumor materials for biomarker assessment, according to data presented at the Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development.

"The basic idea is that CTCs can provide real-time information about a patient's current disease state, acting as a 'liquid biopsy,'" said Siminder Kaur Atwal, Ph.D., senior research associate at Genentech. "They are much less invasive than tumor biopsies because they can be detected from a blood draw and don't require surgical intervention."

For this study, Atwal and colleagues compared the CTC capture efficiency of the Food and Drug Administration-approved CellSearch platform with two biochip platforms, using tumor cell lines spiked into whole blood. They tried to detect epidermal growth factor receptor (EGFR) protein expression in CTCs from patients with lung cancer and HER2 expression or amplification in CTCs in patients with metastatic breast cancer.

Under the tested conditions, CellSearch and the newer biochip platforms offered similar efficiency. Further, capture efficiency was dependent on EpCAM (epithelial cell adhesion molecule) expression.

"This may be a limitation in capturing CTCs from certain tumor types, notably triple-negative breast cancers," Atwal said.

Captured CTCs were amenable to biomarker analyses such as HER2 status, qRT-PCR for breast cancer subtype markers, KRAS mutation detection and EGFR staining by immunofluorescence, the researchers found. In patients with HER2-positive breast cancer, HER2 status in CTCs and tumor tissue generally correlated; however, in one patient subset, HER2 status changed from the primary tumor at diagnosis. This finding indicates that in some cases, CTCs may offer a real-time view of a patient's biomarker status that is different from diagnostic tissue, Atwal said.

Some improvements are
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Revisiting the need to detect circulating tumor cells
2. Improved device provides more rapid, comprehensive analysis of circulating tumor cells
3. Survival in metastatic breast cancer directly linked to circulating tumor cells
4. Circulating tumor cells correlate with poorer survival in pancreatic cancer patients
5. Researchers discover new way to kill pediatric brain tumors
6. Researchers create drug to keep tumor growth switched off
7. Fluorescent probes light up cancerous tumors
8. Scripps Health Begins Pioneering Study of Human Tumor Sequencing in Cancer Patients
9. Drug for advanced kidney cancer shrinks tumors prior to surgery
10. Researchers discover second protective role for tumor-suppressor
11. Personalizing cancer: Creating biomarkers from tumor DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2015)... April 26, 2015 With the FCPX LUT ... X editors can quickly and easily add desaturated color ... contains a mathematical formula for modifying an image. The LUT ... the table. This pack comes with 60 black and white ... and contemporary black and white films. With the FCPX ...
(Date:4/26/2015)... A live auction will be held to ... surgery centers and other medical facilities around the United ... radiology, surgery, endoscopy, lab, anesthesia, exam and much more. ... April 28th starting at 10:00am EDT. The equipment is ... Hiatus Rd., Sunrise, FL 33351. Anyone can participate ...
(Date:4/26/2015)... This annual celebration is one of ... will include a spectacular collection of vendors offering distinctive ... and incense, chimes, vases, candleholders, fleece throws, trivets, jewelry ... unique collection of vendors, guests will have the opportunity ... the Jimmie Jazz Band. , “We are ecstatic ...
(Date:4/26/2015)... Forbes Living is scheduled to ... which is synonymous with clean beaches, sparkling office buildings, and ... major economic influencers in the city on the Pacific Coast ... are pleased to announce the show will be broadcast on ... PM PDT. Tune in to find out what the effervescent ...
(Date:4/26/2015)... (PRWEB) April 26, 2015 MidSouth ... grow throughout the Southeast. MidSouth Pain Treatment Center is ... in Cordova, Southaven, Oxford and Jackson, two ambulatory surgery ... in the Southaven and Cordova locations. , Dr. ... ”I went into medicine to help people, and when ...
Breaking Medicine News(10 mins):Health News:Pixel Film Studios, a FCPX Effects Developer, Announced the Release of FCPX LUT B&W 2Health News:Centurion Service Group to Auction off 1,200 Lots of Medical Equipment 2Health News:It’s Coming! The 5th Annual Tulip Festival & Mother’s Day Celebration at Honor's Haven Resort & Spa! 2Health News:Forbes Living TV Will Air in San Diego, California 2Health News:Growing Pains for MidSouth Pain Treatment Center 2
... Philadelphia, PA, 6 May 2009 Obstructive sleep apnea ... decreased in heart failure (HF) patients managed with beta-blockers ... of Journal of Cardiac Failure ( http://www.elsevier.com/locate/cardfail ... Predictors of Sleep Apnea in Patients with Heart Failure ...
... - With more than ... breast or gynecologic cancers in 2008, Moffitt ... toward focusing more on personalized cancer care treatment ... of women,s oncology.(Photo: http://www.newscom.com/cgi-bin/prnh/20090506/NY11963 )To view ...
... 6 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,Corporation (Nasdaq: BJGP ) (,BMP Sunstone, ... -- Oppenheimer 3rd Annual China Dragon Call Conference, held ... Avenue in New York City. Management is currently, ... 8:30, am ET on Tuesday, May ...
... Hour After Heart Surgery, 45-Year-Old Sits Up in ICU and Writes Notes ... ... Chuck Besen was discharged from University Medical Center (UMC) after making medical ... a donor heart and then a kidney transplant on the same day ...
... Such As AstraZeneca,s Iressa and Roche,s Avastin Will Drive ... New Report from Decision Resources WALTHAM, Mass., May 6 ... and advisory firms focusing on pharmaceutical and healthcare issues, ... China will more than double by 2013, growing from ...
... Families Who Reinforce Lifelong Milk-Drinking Habits at Lower Risk ... gifts that moms pass on to their families, one ... about bone health and osteoporosis, according to the National ... is the theme of this year,s Osteoporosis Awareness ...
Cached Medicine News:Health News:Sleep apnea may not be closely linked to heart failure severity 2Health News:Video: Research in Women's Cancers Leading the Personalized Medicine Revolution 2Health News:Total Artificial Heart Patient 3rd in the World to Receive Dual Transplants 2Health News:Chinese Non-Small-Cell Lung Cancer Drug Market Will More Than Double by 2013 2Health News:Mothers Play a Powerful Role in Determining Strength of Daughters' Bones 2Health News:Mothers Play a Powerful Role in Determining Strength of Daughters' Bones 3Health News:Mothers Play a Powerful Role in Determining Strength of Daughters' Bones 4
(Date:4/24/2015)... April 24, 2015 Boston Scientific Corporation (NYSE: ... 40 th Annual Healthcare Conference on May 6 in ... , executive vice president and chief financial officer, and ... a 35-minute question and answer session regarding the company with ... A live webcast of the presentation and question and answer ...
(Date:4/24/2015)... , Apr. 24, 2015 Research ... has announced the addition of the ... Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station) & End ... - Global Forecast to 2020" report ... laboratory accessories market is expected to reach ...
(Date:4/24/2015)... N.J. , April 24, 2015  Novartis Pharmaceuticals Corporation ... the second year in a row on the annual DiversityInc ... of its 2015 Top 50 Companies for Diversity on April ... NY . NPC also ranked second on the DiversityInc ... Top 10 Companies for Employee Resource Groups list. ...
Breaking Medicine Technology:Boston Scientific To Participate In The Deutsche Bank 40th Annual Healthcare Conference 2Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 2Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 4
... 2011 The American Pharmacists Association (APhA) ... Initiative, a coordinated approach to preventing cardiovascular disease and ... of Health and Human Services (HHS), the Centers for ... Medicaid Services (CMS), the initiative,s goal is to prevent ...
... 13, 2011 - ImpactRx, a Symphony Technology ... impact of promotion on physician prescribing behavior, announced today ... leading provider of insight into the drivers of physician ... highly complementary capabilities of the two companies into a ...
Cached Medicine Technology:American Pharmacists Association Partners with HHS, CDC and CMS in the Million Hearts Initiative 2American Pharmacists Association Partners with HHS, CDC and CMS in the Million Hearts Initiative 3American Pharmacists Association Partners with HHS, CDC and CMS in the Million Hearts Initiative 4ImpactRx Acquires TargetRx 2ImpactRx Acquires TargetRx 3
The PerkinElmer LS 45 Luminescence spectrometer offers versatility, reliability and ease-of-use for routine analyses in an affordable package....
Spectra 2000 Digital Spectrophotometer is designed for quantitative and qualitative analysis in visible range from 320 nm to 1020 nm....
... 400 Series Spectrophotometer ... approach to UV-VIS instrumentation. ... are incorporated into a ... in features and performance ...
... Quebec Colony Counter allows the user to quickly ... models allows for digital counting or manual counting. ... standard lens increasing magnification to 3.0X. The adjustable ... be raised or lowered. The lens also rotates ...
Medicine Products: