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Circuit regulating anti-diabetic actions of serotonin uncovered by UT Southwestern researchers
Date:11/10/2010

ey reactivated the serotonin receptor only in the POMC neurons, the mice no longer displayed insulin resistance in the liver. Restoring the receptor essentially protected the mice from developing the metabolic problems usually found in mice which lack the receptor throughout the body.

Dr. Elmquist said that even though the findings are in mice, they do provide potential insight into blood glucose control in humans.

"It also further reinforces our previous findings that specific subsets of POMC neurons within the brain are responsible for the regulation of liver function and blood sugar metabolism," Dr. Elmquist said.

The next step, he said, is to determine what happens to feeding, body weight and liver metabolism in mice engineered to lack this serotonin receptor only in the POMC neurons.


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Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

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