Navigation Links
Circuit regulating anti-diabetic actions of serotonin uncovered by UT Southwestern researchers
Date:11/10/2010

DALLAS Nov. 11, 2010 New findings by researchers at UT Southwestern Medical Center suggest that serotonin a brain chemical known to help regulate emotion, mood and sleep might also have anti-diabetic properties.

The findings, appearing online this week in Nature Neuroscience, also offer a potential explanation for why individuals prescribed certain kinds of anti-psychotic drugs that affect serotonin signaling sometimes have problems with their metabolism, including weight gain and the development of diabetes.

"In this paper, we describe a circuit in the brain that may explain the anti-diabetic actions of serotonin-receptor signaling," said Dr. Joel Elmquist, professor of internal medicine and pharmacology at UT Southwestern and senior author of the study. "This discovery tells us that drugs that affect serotonin action can have anti-diabetic actions independent of body weight and feeding."

For the current study, the researchers engineered a mouse model in which the expression of a serotonin receptor called 5-hydroxytryptamine 2C was blocked throughout the entire body. Without functioning receptors, the mice developed insulin resistance in their livers.

Previous research has implicated these receptors in the brain in the regulation of energy balance and glucose metabolism throughout the body. When activated by serotonin, this receptor also is known to suppress appetite. Until now, however, it was unclear which type of neuron in the brain mediated the effects of serotonin to regulate glucose, or blood sugar, levels.

To find out, the study authors engineered another set of mice in which the same serotonin receptor was blocked everywhere except within a group of brain cells called pro-opiomelanocortin, or POMC, neurons. The POMC neurons, which are found in the hypothalamus, are also known to play an important role in suppressing appetite and inducing weight loss.

The researchers found that when th
'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Differences in language circuits in the brain linked to dyslexia
2. Dyslexia Linked to Differences in Brain Circuitry
3. Brain Circuitry May Develop Through Adulthood
4. Rare hybrid cell key to regulating the immune system
5. Iron-regulating protein is strong predictor of breast cancer prognosis, study shows
6. Genome Studies Point to Cholesterol-Regulating Genes
7. Cashew seed extract an effective anti-diabetic
8. New Report: The Internet Has More Influence Over Consumer Health Actions than Traditional DTC Channels
9. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
10. Meat Might Be Behind Many Unidentified Allergic Reactions
11. Memory decline linked to an inability to ignore distractions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... December 26, 2014 Recently, iFitDress.com, the popular ... women, has announced its new selection of black one-shoulder ... on sale now; they are available at discounted prices, up ... “The promotion will last for three weeks only. You know, ... Those who are interested in our new items can visit ...
(Date:12/25/2014)... BellasDress has launched its Christmas Sale, offering ... chosen their best-selling lace wedding dresses, vintage bridesmaid dresses ... , Now, BellasDress.com features popular women’s dresses, and ... prices. The business hopes everyone can have a memorable ... “All our elegant products are made with exquisite materials; ...
(Date:12/25/2014)... Miami, FL (PRWEB) December 25, 2014 When ... often find themselves in a frenzy to get rid of ... classroom. But families in Coral Gables now have the solution ... its second salon clinic location, Lice Troopers provides full spectrum ... in the Coral Gable area, including Sunset, Key Biscayne, Brickell, ...
(Date:12/25/2014)... THURSDAY, Dec. 25, 2014 (HealthDay News) -- The risk ... the holidays, so you need to be extra cautious, ... Day, we see a significant increase in patients coming ... at the Suffolk County Volunteer Firefighters Burn Center of ... celebrations should be full of joy, but if not ...
(Date:12/25/2014)... By Dennis Thompson ... -- Researchers could be closing in on a "fountain of ... improve the health of older adults, a new study suggests. ... when given a drug that targets a genetic signaling pathway ... maker Novartis report. The experimental medication, a ...
Breaking Medicine News(10 mins):Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Don't Let Burns Mar Your Holidays 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 2Health News:Researchers Take 'First Baby Step' Toward Anti-Aging Drug 3
... Del., Sept. 14 The airline and pharmaceutical industries both provide ... dangerous if the risks are not properly calculated and dramatically lessened ... people who make and fly airplanes? , , ... webinar on the topic - Captain Ben Berman, senior research associate ...
... , , , ... President Obama in his speech to Congress and the nation ... the cost of medical malpractice and the defensive medicine that ... to control healthcare costs, and Medical Justice, a member based ...
... MONTEREY, Calif., Sept. 14 Mpex Pharmaceuticals, Inc. reported positive top ... novel aerosol formulation of levofloxacin delivered by an optimized Investigational eFlow ... trial, nebulized Aeroquin met the primary endpoint of reducing bacterial counts ... dosing versus placebo. , , "It is exciting ...
... , , , CHERRY ... NVLX) announces today that results from the Company,s ongoing sponsored ... and post-plant in several species of turfgrass. In the coming ... in the Southeastern United States under conditions that are most ...
... ... to announce the launch of the myESMO Professional Networking Community, an innovative online platform ... , ... 2009 -- The European Society for Medical Oncology is today pleased to ...
... , , PLANO, Texas, Sept. ... today announced that it will conduct a free webinar Wednesday, September ... an industry perspective and highlighting recent activities and trends. The webinar ... establish and evolve HIEs. The webinar will be hosted by ...
Cached Medicine News:Health News:Webinar Explores Drug Safety Lessons Pharma Can Learn from Airline Industry 2Health News:MedEncentive and Medical Justice Announce Partnership 2Health News:MedEncentive and Medical Justice Announce Partnership 3Health News:MedEncentive and Medical Justice Announce Partnership 4Health News:Mpex Reports Positive Phase II Results with Aeroquin, Delivered by PARI Pharma's eFlow Technology 2Health News:Mpex Reports Positive Phase II Results with Aeroquin, Delivered by PARI Pharma's eFlow Technology 3Health News:Nuvilex, Inc. Announces Positive Oraphyte(TM) Microplot Results 2Health News:Nuvilex, Inc. Announces Positive Oraphyte(TM) Microplot Results 3Health News:Nuvilex, Inc. Announces Positive Oraphyte(TM) Microplot Results 4Health News:ESMO Online Innovation Helps the Oncology Community Share Knowledge and Enhance Practice 2Health News:ESMO Online Innovation Helps the Oncology Community Share Knowledge and Enhance Practice 3Health News:ESMO Online Innovation Helps the Oncology Community Share Knowledge and Enhance Practice 4Health News:Perot Systems Webinar to Provide Industry Perspective on Health Information Exchanges 2Health News:Perot Systems Webinar to Provide Industry Perspective on Health Information Exchanges 3
(Date:12/22/2014)... Dec. 22, 2014  CytoSorbents Corporation (OTCQB:CTSOD), a ... blood purification technology to help fight deadly inflammation ... countries worldwide, today announced the appointment of Dr. ... as its Senior Vice President of Clinical Development, ... Di Russo is an accomplished pediatric ...
(Date:12/22/2014)... Apnea Sciences ( www.apneasciences.com ) announced it ... Aliso Viejo , California.  Jimmy Fallon , ... and worldwide expansion, a new facility with expanded infrastructure ... snore cure have exceeded our expectations and thus required ... in 23 countries and will be increasing to 39 ...
(Date:12/22/2014)... , Dec. 22, 2014   TRU-D SmartUVC ... no-touch UV disinfection robot, announced today that the General ... contract through November 2019.   This newly ... engage all levels of government purchasers, including Department of ... well as Homeland Security contacts purchasing solutions for the ...
Breaking Medicine Technology:CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... 26, 2012 /PRNewswire-Asia/ -- Clearbridge BioMedics has achieved ... in-vitro diagnostic devices and today launched its ... This is one of the world,s first commercially-available ... (CTC) from blood, using biomechanical properties. The ClearCell™ ...
... ST. LOUIS, March 26, 2012   Sigma-Aldrich ® ... named one of Europe,s Top Employers by the ... of academics, business journalists, trade associations, researchers and ... assessment and acknowledgement.  Sigma-Aldrich is one of nine ...
Cached Medicine Technology:Clearbridge BioMedics Achieves ISO 13485 Certification and Launches ClearCell (TM) System for Cancer Research Markets 2Clearbridge BioMedics Achieves ISO 13485 Certification and Launches ClearCell (TM) System for Cancer Research Markets 3CRF Institute Names Sigma-Aldrich Top Employer Europe 2012 2CRF Institute Names Sigma-Aldrich Top Employer Europe 2012 3
The Acute Care myoglobin method is an in vitro diagnostic test for the measurement of myoglobin in heparinized whole blood /plasma. Myoglobin measurements can be used as an aid in diagnosing myocardi...
... true automation and continuous random access ... assays for thyroid, anemia, cardiac, reproductive, ... are currently available, with infectious disease ... can simultaneously process 60 accessible samples ...
IRMA kit for detection of the cardiac marker Myoglobin...
... BioCheck Prolactin ELISA is intended for the ... This assay is useful in the diagnosis ... pituitary and hypothalamus. The BioCheck Prolactin Quantitative ... a solid phase enzyme-linked immunosorbent assay. The ...
Medicine Products: