Navigation Links
Circuit regulating anti-diabetic actions of serotonin uncovered by UT Southwestern researchers
Date:11/10/2010

DALLAS Nov. 11, 2010 New findings by researchers at UT Southwestern Medical Center suggest that serotonin a brain chemical known to help regulate emotion, mood and sleep might also have anti-diabetic properties.

The findings, appearing online this week in Nature Neuroscience, also offer a potential explanation for why individuals prescribed certain kinds of anti-psychotic drugs that affect serotonin signaling sometimes have problems with their metabolism, including weight gain and the development of diabetes.

"In this paper, we describe a circuit in the brain that may explain the anti-diabetic actions of serotonin-receptor signaling," said Dr. Joel Elmquist, professor of internal medicine and pharmacology at UT Southwestern and senior author of the study. "This discovery tells us that drugs that affect serotonin action can have anti-diabetic actions independent of body weight and feeding."

For the current study, the researchers engineered a mouse model in which the expression of a serotonin receptor called 5-hydroxytryptamine 2C was blocked throughout the entire body. Without functioning receptors, the mice developed insulin resistance in their livers.

Previous research has implicated these receptors in the brain in the regulation of energy balance and glucose metabolism throughout the body. When activated by serotonin, this receptor also is known to suppress appetite. Until now, however, it was unclear which type of neuron in the brain mediated the effects of serotonin to regulate glucose, or blood sugar, levels.

To find out, the study authors engineered another set of mice in which the same serotonin receptor was blocked everywhere except within a group of brain cells called pro-opiomelanocortin, or POMC, neurons. The POMC neurons, which are found in the hypothalamus, are also known to play an important role in suppressing appetite and inducing weight loss.

The researchers found that when they reactivated the serotonin receptor only in the POMC neurons, the mice no longer displayed insulin resistance in the liver. Restoring the receptor essentially protected the mice from developing the metabolic problems usually found in mice which lack the receptor throughout the body.

Dr. Elmquist said that even though the findings are in mice, they do provide potential insight into blood glucose control in humans.

"It also further reinforces our previous findings that specific subsets of POMC neurons within the brain are responsible for the regulation of liver function and blood sugar metabolism," Dr. Elmquist said.

The next step, he said, is to determine what happens to feeding, body weight and liver metabolism in mice engineered to lack this serotonin receptor only in the POMC neurons.


'/>"/>

Contact: Kristen Holland Shear
kristen.hollandshear@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Related medicine news :

1. Differences in language circuits in the brain linked to dyslexia
2. Dyslexia Linked to Differences in Brain Circuitry
3. Brain Circuitry May Develop Through Adulthood
4. Rare hybrid cell key to regulating the immune system
5. Iron-regulating protein is strong predictor of breast cancer prognosis, study shows
6. Genome Studies Point to Cholesterol-Regulating Genes
7. Cashew seed extract an effective anti-diabetic
8. New Report: The Internet Has More Influence Over Consumer Health Actions than Traditional DTC Channels
9. Father Channels His Grief into Advocacy, Promotes Simple Actions to Make Hospitals Safer for Children
10. Meat Might Be Behind Many Unidentified Allergic Reactions
11. Memory decline linked to an inability to ignore distractions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... January 16, 2017 , ... ... Dental Center, is currently offering complimentary consultations and financing for orthodontics for a ... for bite irregularities and learn about their orthodontic options. Walk-in, late-evening, Saturday, and ...
(Date:1/16/2017)... ... 2017 , ... Permobil has just completed the acquisition of ... systems has a well-earned reputation for premium quality, with a focus on fit ... in the custom seating business, which enjoys strong demand, and it complements Permobil’s ...
(Date:1/16/2017)... ... 16, 2017 , ... Atlanta-based incentive company Incentive Solutions ... wheelchair accessibility industry, BraunAbility . Incentive Solutions will provide BraunAbility a debit ... With this new incentive plan, BraunAbility plans to continue their tradition of excelling ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... ... editor, attorney, science teacher, http://www.ageofautism.com/legal , Sharon Kleyne, America’s leading water ... Heckenlively to her nationally syndicated radio program, The Sharon Kleyne Hour Power of ...
(Date:1/16/2017)... ... 2017 , ... In 1985, the International Association of Eating ... an international multidisciplinary group of healthcare treatment providers and helping professions who treat ... mission at the grassroots level, iaedp launched MemberSHARE, an online peer community solely ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)...  This report by Persistence Market Research examines ... the period 2016–2024. The primary objective of the ... to market opportunities in the global peripherally inserted ... the various dynamics that are expected to influence ... global peripherally inserted central catheters market over the ...
(Date:1/16/2017)... 16, 2017 Derek H. Potts , ... was recently appointed Liaison Counsel in California,s ... Xarelto cases. In this role, Potts was assigned to ... actively assist the Court and Co Lead Plaintiff,s Counsel. ... Adelman Jackson Fairchild & Wade and Ruth ...
(Date:1/16/2017)... ROCKVILLE, Md. , Jan. 16, 2017 /PRNewswire/ ... tomography (CT) systems market is valued at $4.9 ... applications for CT, coupled with an aging population ... incidence of chronic disease, is propelling the market ... report, Computed Tomography Markets , focuses on ...
Breaking Medicine Technology: