Navigation Links
Circassia Announces Successful Results From Phase II Clinical Study of ToleroMune(R) Cat Allergy Therapy

OXFORD, England, November 20 /PRNewswire/ -- Circassia Ltd, a specialty biopharmaceutical company focused on allergy, today announced positive results from a recently completed phase II clinical study of its ToleroMune(R) cat allergy therapy, which successfully identified the optimal dosing regimens to progress into late-stage development. The clinical trial, which was the first of its kind in the field of cat allergy immunotherapy, showed that Circassia's ToleroMune treatment was extremely well tolerated and greatly reduced sufferers' symptoms.

Circassia conducted the double-blind study in Canada, where 121 subjects with confirmed cat allergies were randomised to receive placebo or one of four different treatment regimes with standardised doses of ToleroMune. The volunteers were exposed to cat allergens (aerosolised dander) in an environmental exposure chamber for 3 hours each day on four consecutive days, both before and after treatment. At set time points the subjects scored their ocular and nasal symptoms to allow investigators to measure the effect of the ToleroMune treatment. This is the first trial of a cat allergy immunotherapy to use this validated approach.

The study's results demonstrate that ToleroMune therapy can dramatically reduce both nasal and ocular allergy symptom levels, and that the treatment effect grows as the duration of exposure increases and symptoms are at their greatest. The optimal regimen decreased total symptom scores by 67% compared with placebo. Throughout the study ToleroMune treatment was extremely well tolerated, with a safety profile similar to placebo. This contrasts with many traditional immunotherapies, which are associated with a range of local tolerability issues and sometimes severe and even life-threatening adverse events.

"These positive phase II results are extremely important for Circassia as they identify the optimal treatment regime to move into the final stages of development for our cat allergy therapy, and will prove invaluable as we progress our broader portfolio of ToleroMune products," said Steve Harris , Circassia's CEO. "We are particularly pleased that the ToleroMune treatment achieved such a marked improvement in ocular symptoms, which can be a particular problem in cat allergy. As well as benefiting patients, this effect scientifically validates the ToleroMune approach and its novel focus on generating regulatory T cells to shut down this type of IgE-mediated allergic response."

About Circassia

Circassia is a specialty biopharmaceutical company focused on the field of allergy. The company's range of allergy therapeutics utilises its proprietary T-cell epitope desensitisation technology, ToleroMune, in a short treatment regime without the need for adjuvants or other immune stimulators. Circassia's products offer potential major clinical benefits compared with existing therapies, and consequently have significant market opportunities. Over 150 million people suffer from allergic rhinitis in the US and Europe, and the current treatment market is approximately $12 billion per year.

ToleroMune technology has additional potential regulatory and supply chain benefits. The short peptides utilised in Circassia's products are manufactured chemically, in contrast to existing allergen immunotherapies, which are purified from natural sources. Circassia's approach applies the chemistry, manufacturing and control standards associated with conventional pharmaceuticals to immunotherapy. This fits with changes in the European regulatory environment, where authorities are increasingly treating allergen immunotherapies as pharmaceutical products, and requiring elimination of the batch-to-batch potency variability that is an intrinsic feature of many currrent treatments.

Circassia has a highly experienced management team with a proven track record in product development and commercialisation. Having successfully completed two fundraising rounds the company is backed by a syndicate of world-class venture capital and institutional investors, including Imperial Innovations, Lansdowne Partners, Goldman Sachs and Invesco Perpetual.

    For more information please visit


    Steve Harris
    Tel: +44-(0)1865-784574

    Rob Budge
    RJB Communications
    Tel: +44-(0)1865-760969
    Mobile: +44-(0)7710-741241

SOURCE Circassia Ltd

SOURCE Circassia Ltd
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. IVF Florida Announces New Patient Finance Solution for Fertility Treatments
2. Secretary Shinseki Announces Study of Vietnam-Era Women Veterans
3. Great Customer Service Just Got Better as Emedco Announces the Launch of their Completely Updated and Enhanced Website
4. Nationwide Imaging Services, Inc., Leader In Diagnostic Imaging Equipment, Announces The Creation Of New Business Division Nationwide Medical Equipment Services
5. Parascript Announces AccuDetect 3.0 Computer Aided Detection (CAD) Algorithms With Improved Performance for CAD Vendors and Manufacturers of Mammography Systems
6. Universal Health Services, Inc. Announces Stock Split and Cash Dividend Increase
7. GettingHired Announces Additional Funding for Continued Growth as Well as R&D of New Product for Long Term Disability and Workers Comp.
8. Ziosoft Announces the Appointment of Rob Royea, Vice President, Sales and Marketing
9. WAT-AAH!, The First Functional Bottled Water For Kids, Announces The Release of WATs-THE-WORD?!
10. Oncolytics Biotech(R) Inc. Announces Terms of Unit Offering
11. Albireo Announces Positive Clinical Data on A3309 in Patients with Chronic Idiopathic Constipation
Post Your Comments:
(Date:10/10/2015)... ... ... walk with crutches for the rest of my life," said an inventor from San Diego, ... give me more independence and freedom would be amazing. This inspired me to invent a ... STRAP IN to enable an individual to walk with crutches without having to use his ...
(Date:10/10/2015)... ... October 10, 2015 , ... The Bank of America 500 NASCAR ... Saturday, October 10th, defending race winner, Kevin Harvick, will battle it out ... Earnhardt Jr., and all of the stars of the NASCAR Sprint Cup Series. ...
(Date:10/10/2015)... ... 2015 , ... Attending medical school and working on a ... children. Depending on the school, the exact details of the medical program differ; ... in a medical school must complete undergraduate classwork and requirements before moving into ...
(Date:10/10/2015)... ... October 10, 2015 , ... Well-known ... pleased to be recognized by The National Law Journal for inclusion in their ... law firms across the United States who obtained the largest awards for their ...
(Date:10/9/2015)... ... October 09, 2015 , ... Doctors on Liens has ... , to provide highly needed medical care to personal injury victims. When personal ... to diagnose, document and treat the variety of conditions ailing them. With the ...
Breaking Medicine News(10 mins):
... Report: , , Study highlights: , , Cardiac ... EMS personnel due to a number of external factors. , ... to give high-quality CPR and other resuscitation efforts before transporting ... guidelines for transporting cardiac arrest patients and determining when to ...
... Pioneering procedure aims to repair damaged cardiac muscle, surgeons say ... they,ve performed the first procedure in which a patient received ... attack damage. , The 39-year-old man is the first of ... a phase 1 clinical trial being conducted at Cedars-Sinai Heart ...
... obliged to bring unresponsive patient to hospital, study finds , ... heart attack that occurs outside of a hospital are slim, ... hospital anyway because a variety of factors keep them from ... In the United States, paramedics treat almost 300,000 people with ...
... don,t perform better than standard criteria, study finds , ... cardiac risk, such as inflammation-linked C-reactive protein (CRP), ... factors such as smoking, obesity, high cholesterol and physical ... markers have been touted as a better way of ...
... Physiological changes associated with the metabolic syndrome may play ... according to study results published in Cancer Epidemiology, ... Association for Cancer Research. The metabolic syndrome, ... factors including abdominal obesity, high blood glucose levels, impaired ...
... improperly , TUESDAY, June 30 (HealthDay News) -- ... dose for Tylenol and other pain medications should be ... recommended lowering the maximum dose of over-the-counter acetaminophen -- ... , Part of the problem, according to an FDA ...
Cached Medicine News:
(Date:10/9/2015)... Lilly and Company (NYSE: LLY ) and Locemia ... Locemia,s intranasal glucagon, a potential treatment for severe hypoglycemia ... which is currently in Phase III clinical trial testing, ... hypoglycemia. --> --> ... formulation that is delivered in an emergency situation using ...
(Date:10/9/2015)... , Oct. 9, 2015 Regardless ... Device environments, corporate communications is perpetually evolving. Due ... and professionals must continuously adjust their business-to-business (B2B) ... these adjustments is difficult, but also critical as ... options. --> ...
(Date:10/9/2015)... -- Regulatory affairs groups within medical device organizations face a ... These specialized groups are charged with ensuring that their ... to the development and marketing of medical device products. While ... their own internal effectiveness and efficiencies to remain productive and ... --> Optimal resourcing and staffing help ...
Breaking Medicine Technology:
... kids are outside playing soccer, baseball, or lacrosse, jumping rope, ... know, there is a trip to the emergency room. Childhood ... is the refined work of physicians and hospitals but it ... while injured. A common problem parents face is how to ...
... Mass., May 15, 2012  IntelligentMDx (IMDx) announced today that ... qualitative in vitro diagnostic test designed for ... (GBS) for use in screening pregnant women and those ... GBS is responsible for life-threatening bacterial infections in newborns, ...
Cached Medicine Technology:
ArcticTemp Upright Freezer -20C. Thick wall insulation keeps your samples colder. Reversible door with magnetic gaskets. 2 shelves and a wire basket. Heavy duty compressor with 5 year warranty....
Undercounter Freezer -25C. White. Front opening freezer. 4 cubic ft capacity. Reversible door. Three slide-out drawers. Extra thick CFC insulation. Front lock. Front indicator lights. Attractive tabl...
... a portable system for routine pH, mV ... compensated pH results can be obtained when ... a 3-in-1 electrode. • Fast and easy ... automatic buffer recognition for five buffers (pH ...
... The F 265 is a highly accurate portable, ... and temperature measurements. Temperature compensated pH results can ... (ATC) or a 3-in-1 electrode. • This GLP/GMP ... to a printer or a computer. Up to ...
Medicine Products: