Navigation Links
Circadian clock gene rhythms in brain altered in depression, UC Irvine Health study finds
Date:5/13/2013

n the study, the researchers analyzed genome-wide gene expression patterns in brain samples from 55 individuals with no history of psychiatric or neurological illness and compared them to the expression patterns in samples from 34 severely depressed patients.

The investigators isolated multiple RNA samples from six regions of each brain and arranged the gene expression data around a 24-hour cycle based on time of death. Several hundred genes in each of six brain regions displayed rhythmic patterns of expression over the 24-hour cycle, including many genes essential to the body's circadian machinery.

In the end, they had a near-complete understanding of how gene activity varied throughout the day in the cells of the six brain regions they studied.

"There really was a moment of discovery when we realized that many of the genes that we saw expressed in the normal individuals were well-known circadian rhythm genes and when we saw that the people with depression were not synchronized to the usual solar day in terms of this gene activity," said Jun Li, an assistant professor in the Department of Human Genetics at the University of Michigan who led the analysis of the massive amount of data generated by the rest of the team.

The researchers add that this information can be used to help find new ways to predict depression, and fine-tune treatment for depressed patients.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. 2013 Wiley Prize awarded for circadian rhythm research
2. Circadian clock research may enable designer plants, and cancer and diabetes treatments
3. Coordinating the circadian clock: Molecular pair controls time-keeping and fat metabolism
4. MinuteHound Releases Time Clock Software For Hotel Operations
5. PC Time Clock Software: Updated EzTimeSheet Boosts Productivity For CA Small Businesses
6. Introducing the Roco Verre Backplate Time Zone Clocks Range
7. Online Clock Shares New Research Explaining Why People are Afraid of the Dark
8. Employee TimeClock: EzTimeSheet Software Adds Flexibility With New Data Upload Feature
9. MinuteHound Releases Time Clock Software Featuring Secure Biometric Technology for Business Applications
10. New Karlsson Vintage Wall Clocks Added at Contemporary Heaven
11. Tiny piece of RNA keeps clock running in earliest stages of life
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... 18, 2015 "I wanted to ... create a healthful juice that contained essential vitamins, ... Md. "It increases my energy, improves skin elasticity ... He developed Tapp's Juice to contain fruits, vegetables ... prevent physical and mental fatigue. It features a ...
(Date:4/18/2015)... has released a new blog post explaining how to ... , Drivers can find accurate information about various auto ... website can help drivers compare the newest and best ... whole process is designed to be convenient, free and ... quotes is advantageous because it allows clients to find ...
(Date:4/18/2015)... (PRWEB) April 18, 2015 More than ... sale now at TheCelebrityDresses.com, the #1 online store carrying ... ongoing many girls have got their perfect dresses for ... the celebrity fashion prom dresses at TheCelebrityDresses.com would be ... designed more than 2000 prom dresses inspired by the ...
(Date:4/18/2015)... 2015 PHOENIX, ARIZONA – In March, ... 11 other secure destruction professionals across the United States, ... He will now display “CSDS” as a professional title ... the National Association of Information Destruction 2015 Annual Conference ... Texas. Of the 20 people who took the exam, ...
(Date:4/17/2015)... 2015 Rosetta Radiology is proud to ... their list of diagnostic imaging services. This solidifies them ... the Upper East Side of Manhattan. , The new ... The addition of PET-CT, combined with Rosetta’s state of ... to work with patients through several stages of the ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:Prom Dresses 2015 on Sale at TheCelebrityDresses.com 2
... American Society,for Therapeutic Radiology and Oncology is pleased to ... Oriental Republic of,Uruguay, will present a special guest lecture ... 1 in Los Angeles. Dr. Vazquez, who,is a radiation ... speak October 30 at 9:00 a.m. at the Los ...
... but not all , WEDNESDAY, Oct. 17 (HealthDay News) -- ... pain. , That,s the conclusion of Israeli researchers who reviewed ... insoles to sham insoles or no treatment for back pain ... of 256 people that focused on the use of insoles ...
... Help Advance Research-, MISSION VIEJO, Calif., Oct. ... for its innovative genomic search,technology, SLIM Search(TM), Inc. ... The SLIM Search genomic search tool delivers greater ... 1.3 includes the following features: * ...
... 17 After completing its review of safety,and ... Board (DSMB) has recommended that the pivotal Phase ... Edema) Study,continue under the current protocol, without change. ... for the treatment of diabetic macular edema (DME). ...
... Oct. 17 IRIDEX,Corporation (Nasdaq: IRIX ) announced ... and Chief Executive Officer, and as a member of,the ... The Board of,Directors has appointed Theodore A. Boutacoff, who ... Directors, to serve as the Company,s President,and Chief Executive ...
... - For the Nine Months (to 31 August) a 46% Sales ... in EBIT to EUR34.8m (EUR6.2m) - Marked Improvement in Adjusted ... Fall in Interest Charges Since the IPO - CEO Dr. ... In the first nine months of its financial year (to ...
Cached Medicine News:Health News:President of Uruguay to Speak at ASTRO Annual Meeting 2Health News:Release 1.3 of SLIM Search Now Available 2Health News:DSMB Supports Continuation of the Phase 3 Clinical Trial of Medidur(TM) FA for the Treatment of DME 2Health News:DSMB Supports Continuation of the Phase 3 Clinical Trial of Medidur(TM) FA for the Treatment of DME 3Health News:DSMB Supports Continuation of the Phase 3 Clinical Trial of Medidur(TM) FA for the Treatment of DME 4Health News:Growth Trend for Gerresheimer Continues Unabated - Debt Reduction 2Health News:Growth Trend for Gerresheimer Continues Unabated - Debt Reduction 3Health News:Growth Trend for Gerresheimer Continues Unabated - Debt Reduction 4Health News:Growth Trend for Gerresheimer Continues Unabated - Debt Reduction 5
(Date:4/17/2015)... , April 17, 2015 Today, ... honored 13 employees from 12 biopharmaceutical companies as ... efforts in policy advocacy and community service. ... Health Champion Awards were created by the biopharmaceutical ... excelled in their careers, but have also shown ...
(Date:4/17/2015)... , Apr. 16, 2015 Research and Markets ... the "Corporate Reputation of Pharma in 2014 - ... Edition" report to their offering. For ... opinions on the corporate reputation of the pharmaceutical industry ... health with the views of patient organisations representing all ...
(Date:4/16/2015)... , April 16, 2015 Vanda Pharmaceuticals ... focused on the development and commercialization of products for ... it will release results for the first quarter of ... closes. The Company will host a ... 6, 2015, during which Vanda management will discuss the ...
Breaking Medicine Technology:PhRMA Applauds 2015 We Work For Health Champion Award Winners 2PhRMA Applauds 2015 We Work For Health Champion Award Winners 3Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 2Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 3Vanda Pharmaceuticals to Announce First Quarter 2015 Financial Results on May 6, 2015 2
... Dec. 22, 2010 Haemonetics Corporation (NYSE: ... Chief Executive Officer, will present at the J.P. Morgan ... 2011 at 1:30 pm Pacific time.  The ... at http://jpmorgan.metameetings.com/webcasts/healthcare11/directlink?ticker=HAE .  The webcast ...
... ISTA Pharmaceuticals, Inc. (Nasdaq: ISTA ), today ... update webcast/conference call after the market closes on January ... Vicente Anido, Jr., Ph.D., and Chief Financial Officer and ... 2011 guidance, give a commercial and new product pipeline ...
Cached Medicine Technology:ISTA Pharmaceuticals Announces 2011 Guidance and Pipeline Update Webcast/Conference Call on January 5, 2011 2
... cool-running, energy efficient LEDs (Light Emitting Diodes) ... see without affecting the darkened refracting environment. ... free so you'll never need to change ... a limited lifetime warranty, the best in ...
... The Reichert CT200 Tonometer ... the XCEL 250 and XCEL ... also compatible with other Zeiss-style ... mounted on the top of ...
10 (mm) smooth platform; Serrated handle in stainless steel....
Compatible with the Volcano Therapeutics Trak Back II Disposable Catheter Pullback Device,and the Volcano Therapeutics In-Vision Imaging System....
Medicine Products: