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Cincinnati Children's researchers develop first molecular test to diagnose eosinophilic esophagitis
Date:11/21/2013

ils in the esophagus the tube that connects the mouth to the stomach. The disease is caused by food allergies and possibly airborne allergens as well. Symptoms typically resemble gastro esophageal reflux but do not get better with anti-reflux medications. These symptoms may include trouble swallowing, vomiting, abdominal pain, and food getting stuck in the esophagus.

In an accompanying editorial, journal section editors Anson W. Lowe and Richard H. Moseley remark that "these findings provide proof of principle for the use of a tissue based molecular test in the diagnosis of EoE and highlight the advantages of such techniques over histologic analysis."

Cincinnati Children's has filed for several patents on the technology, one of which has been issued. The medical center also has entered into an option agreement with Diagnovus LLC, a specialized molecular diagnostic company focused on delivering personalized diagnostic information and services to physicians treating patients suffering from rare, orphan and less frequent diseases. The option will allow the company to validate the technology and potentially enter into a license agreement.

In addition to Dr. Rothenberg and Dr. Wen, other authors include scientists in the divisions of allergy and immunology; gastroenterology, hepatology and nutrition; and pathology.


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Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

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