Navigation Links
Cincinnati Children's researchers develop first molecular test to diagnose eosinophilic esophagitis
Date:11/21/2013

Researchers at Cincinnati Children's Hospital Medical Center have developed the first molecular test to diagnose eosinophilic esophagitis (EoE), a chronic upper gastrointestinal disorder. The incidence of EoE has skyrocketed since it was first characterized two decades ago.

The test, based on a 96 gene expression profile, "offers an unprecedented opportunity to improve diagnosis and treatment, and a platform approach for other inflammatory diseases," says Marc Rothenberg, MD, PhD, director of allergy and immunology at Cincinnati Children's and senior author of the study. Up to now, gene expression profiling has not yet been well applied to inflammatory diseases, he says.

The study is published in the Dec. issue of the journal Gastroenterology. The lead author of the study is Ting Wen, PhD, a researcher in the Rothenberg lab at Cincinnati Children's.

The researchers used bioinformatics tools to develop the EoE diagnostic panel, which is composed of a 96 gene PCR array considered the most reliable tool for analyzing the expression of a focused panel of genes.

The panel was developed from a set of esophageal biopsy samples from children diagnosed with EoE and from some children who do not have EoE. The researchers applied the panel to 148 children and adults with EoE and found it identified patients with approximately 96 percent sensitivity and 98 percent specificity. The diagnostic panel was also able to distinguish patients in remission from those who did not have EoE.

The researchers have preliminary evidence that the panel could identify patients likely to have disease relapse following treatment.

"We aimed to provide a reliable next-generation diagnosis of eosinophilic esophagitis, and to offer a component of personalized medicine to each patient," says Dr. Wen. "We hope to ease the suffering of every child with EoE."

EoE is characterized by a large number of white blood cells called eosinoph
'/>"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Home Care Assistance of Cincinnati Receives Home Care Pulse Certification
2. Home Care Assistance Opens New Cincinnati Office
3. Cincinnati Scientologists Kick Off School Year with an Anti-Drug Message
4. Actors, Models and Talent for Christ (AMTC) Will Hold Cincinnati Auditions for Up and Coming Talent on September 14th, 2013.
5. On September 14th, Actors, Models and Talent for Christ Will Hold Cincinnati Auditions for Up and Coming Talent of All Ages
6. NFL Season Ticket Packages: NFL Season Ticket Prices Slashed on Detroit Lions, Atlanta Falcons, Denver Broncos, New York Giants, Cincinnati Bengals, St. Louis Rams & More
7. Maroon 5 & Kelly Clarkson Ticket Prices Slashed for Concerts in Long Island, Holmdel, Cincinnati, Pittsburgh, Camden/Philly, Boston/Mansfield, Chicago, Cleveland & Detroi
8. Blake Shelton Tickets: Cheap Concert Tickets Slashes Ticket Prices in Long Island, Virginia Beach, Indianapolis, DC, St. Louis, Cincinnati, Pittsburgh, Chicago & Camden
9. Housh Inc. Recognized as One of Cincinnatis Fastest Growing Companies
10. Seva Call Launches to Put Cincinnati in Sync With Service Pros in Seconds
11. University of Cincinnati Campus Recognized Among the Greenest in America
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... in the popular Swedish children,s TV show Bolibompa, ... A new study from the University of Gothenburg ... programmes as well as the link between young ... , Steingerdur Olafsdottir,s doctoral thesis focuses on the ... TV show Bolibompa. Healthy foods dominated in the ...
(Date:4/23/2014)... of Midlife Occupational and Leisure Time Physical Activity on ... activity in midlife increases the risk of mobility limitation ... risk. This is found in a study which followed ... study was conducted at the Gerontology Research Center in ... Heavy physical labor is often repetitive, wears the body ...
(Date:4/22/2014)... popular high school sport in the United States with ... researchers in the Center for Injury Research and Policy ... and describe the occurrence and distribution patterns of basketball-related ... athletic training setting among adolescents and teens. , The ... Training , examined data relating to adolescents 13-19 years ...
(Date:4/22/2014)... April 22, 2014 Researchers at UT Southwestern Medical ... from depression . , A team of ... by which ghrelin (a hormone with natural anti-depressant properties) ... potentially powerful new treatment for depression in the form ... The study, published online in April,s issue of ...
(Date:4/22/2014)... Working with mice and rabbits, Johns Hopkins scientists have ... and breakdown, successfully preventing the development of atherosclerosis, the ... number-one cause of death among humans. The condition develops ... renders them stiff, narrowed and hardened, greatly reducing their ... and the brain. , In a series of experiments, ...
Breaking Medicine News(10 mins):Health News:High-calorie and low-nutrient foods in kids' TV 2Health News:Midlife occupational and leisure-time physical activity limits mobility in old age 2Health News:New study finds 2.5 million basketball injuries to high school athletes in 6 seasons 2Health News:New study finds 2.5 million basketball injuries to high school athletes in 6 seasons 3Health News:Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches 2Health News:Depressed? Researchers identify new anti-depressant mechanisms, therapeutic approaches 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 2Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 4
... BlueCross BlueShield of South Carolina announced today that the ... held during lunchtime hours on Wednesday, April 29, 2009.Blue ... well as other employers, will encourage their employees to ... in a 30-minute lunchtime walk. The goal of National ...
... 2 Accelerated Community Oncology Research Network (ACORN(TM)), ... highlights of its annual Principal Investigators, Meeting held ... from community-based oncology practices throughout the United States ... emerging treatment trends, as well as promising new ...
... to Include 24-oz and Convenient 4-oz Travel Size ... (Nasdaq: PURE ) today announced an ... PURE,s silver dihydrogen citrate (SDC)-based disinfectant as OneShot ... OneShot Plus product line. OneShot Plus DD ...
... BIGLERVILLE, Pa., March 2 The first Eklin ... recently installed at Dr.,Flake,s Animal Wellness Clinic which ... Oxford. The state-of-the-art system,from Eklin Medical Systems, the ... benefit the area,s thousands of veterinary patients,supporting the ...
... SynCare, LLC, announces the extension of its contract ... management. MHS, a Medicaid Managed Care Company, serving SCHIP ... assist the company in providing comprehensive care and support ... to continuing our partnership with SynCare for prenatal care ...
... are vegans and vegetarians most affected, study says , , MONDAY, March ... B12 in their blood before and after conception have a greater ... a new study says. , Most at risk may ... meat and animal-based foods, noted an American and Irish research team ...
Cached Medicine News:Health News:S.C. BlueCross to Celebrate Third Annual National Walk @ Lunch Day With Community Events in Columbia, Charleston, Greenville 2Health News:ACORN's Success in Delivering Top Quality Research Portfolio to Community-Based Oncology Practices Presented at Annual Investigator Meeting 2Health News:ACORN's Success in Delivering Top Quality Research Portfolio to Community-Based Oncology Practices Presented at Annual Investigator Meeting 3Health News:Sterifide Laboratories to Launch 'Powered by SDC' OneShot Plus Disinfectant and Deodorizer 2Health News:Sterifide Laboratories to Launch 'Powered by SDC' OneShot Plus Disinfectant and Deodorizer 3Health News:Sterifide Laboratories to Launch 'Powered by SDC' OneShot Plus Disinfectant and Deodorizer 4Health News:Dr. Flake's Animal Wellness Clinic Installs Adams County's First Eklin Digital Radiography System 2Health News:Dr. Flake's Animal Wellness Clinic Installs Adams County's First Eklin Digital Radiography System 3Health News:SynCare Receives Managed Health Services Contract Renewal 2Health News:B12 Deficit May Boost Risk of Birth Defects 2
(Date:1/15/2014)... As health officials across the Midwest warn against the widespread ... Michigan will offer free diagnostic testing for ... to administer tests and, in some cases, fill the matching ... the study. The Grand Rapids, Mich. ...
(Date:1/15/2014)... 2014  Novation, the leading health care supply chain expertise, ... reseller (VAR) national contracts that expand its portfolio to ... lower costs. These include manufacturer product and service agreements, ... and ongoing IT consulting support. New ...
(Date:1/15/2014)... 15, 2014 Massachusetts General Hospital (MGH), the ... ) announced today that they have launched a ... therapeutic targets and develop novel therapies for inflammatory ... millions worldwide. The MGH-Broad-Amgen collaboration brings together scientists ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... Control is a liquid control ... busy immunoassay laboratory. With a ... serum based control can replace ... products for immunoassay and therapeutic ...
The Acceava hCG Combo test provides superior performance for the diagnosis of pregnancy with a simple procedure that provides easy to read black on white results in 3 minutes for urine or 5 minutes f...
Invacare 5 Oxygen Concentrator with Sens O2, 230 VAC - Intl....
The Acceava Trichomonas Rapid Test is an immunochromatographic assay that detects pathogen antigens directly from vaginal swabs. Results are rapid, occurring within approximately 10 minutes....
Medicine Products: