Navigation Links
Cigarettes leave deadly path by purging protective genes
Date:1/23/2008

A University of Rochester scientist discovered that the toxins in cigarette smoke wipe out a gene that plays a vital role in protecting the body from the effects of premature aging. Without this gene we not only lose a bit of youthfulness but the lungs are left open to destructive inflammation and diseases such as chronic obstructive pulmonary disease (COPD) and lung cancer.

By identifying the Sirtuin (SIRT1) genes role in pulmonary disease, scientists also hope to find ways to restore it and jump-start lung healing. Theyve begun testing the powerful antioxidant resveratrol, which is extracted from red grape skins, to develop a treatment to target SIRT1 and reverse lung damage, or at least enhance the way standard COPD therapies work.

This novel protein will allow us to program our bodys immune-inflammatory system against lung damage and premature aging. The hallmark of this discovery is that we may be able to provide remedies to millions of smokers who would like to quit but cannot kick their addiction, and millions of former smokers who, despite quitting, remain at risk for illness as they age, said Irfan Rahman, Ph.D., associate professor of Environmental Medicine and an investigator in the University of Rochesters Lung Biology and Disease Program.

The research was published in two separate studies, in the American Journal of Respiratory Critical Care Medicine, appearing online Jan. 3, 2008, and in the American Journal of Physiology, appearing Dec. 27, 2007.

Approximately 23 million Americans have COPD, which is induced by inflammation and results in progressive breathlessness. By the year 2020, it is expected to be the third leading cause of death worldwide; today at least 9 percent of the elderly population is estimated to suffer from debilitating lung conditions.

Rahman has spent years studying how the 4,700 toxic chemical compounds in cigarettes assault lung tissue. He also focuses on why some people seem g
'/>"/>

Contact: Leslie Orr
leslie_orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hookah Smoking as Tough on Lungs as Cigarettes
2. Decreasing access to cigarettes for youth in the Minnesota Adolescent Community Cohort Study
3. Nicotine-Reduced Cigarettes Could Boost Quitting
4. Filtered Cigarettes Blamed for Huge Rise in Type of Lung Cancer
5. dLIFETV Premieres Eighth Season With Baseballs Comeback Player Dmitri Young and Leave It To Beavers Jerry Mathers
6. Sedgwick CMS and UnitedHealth Group to Develop Integrated Disability, Medical, Workers Compensation and Leave Administration Services for Employers
7. Holidays Dont Have to Leave You Heavier
8. Hooray for the Bay! San Francisco Officially Named Best Place to Leave Your Heart...and Keep Your Health
9. Obesity Leaves More Americans With Physical Limitations
10. Its More Than the Turkey Dinner That Will Leave You Feeling Bloated This Thanksgiving
11. Pelosi Statement on House Vote to Extend Family and Medical Leave for Military Families
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... HealthDay Reporter , TUESDAY, Oct. 21, ... may lead to increased blood pressure, according to a new ... in blood pressure for young adult women or for teenagers, ... drank lightly or moderately, their risk of high blood pressure ... parallels studies in older adult men and women," said lead ...
(Date:10/22/2014)... News) -- Measures taken by Firestone officials at the ... have limited the spread of the disease there and ... Natural Rubber Co. provides health services to about 80,000 ... populated communities. Between Aug. 1 and Sept. 23, ... those 80,000 people. That incidence rate of 0.09 percent ...
(Date:10/22/2014)... Dennis Thompson HealthDay Reporter ... cameraman who was diagnosed with Ebola while working for NBC ... and can leave the special isolation unit at Nebraska Medical Center ... weeks, the hospital said Tuesday. A blood test confirmed by ... Mukpo, 33, can head home to Providence, R.I., NBC News ...
(Date:10/20/2014)... With a mere 19 days to November ... brief fundraising stop at the  Law Offices of ... a debate last night with his opponent Gov. Rick ... first seven minutes because Crist had an electric fan ... in one word: "weird." , Before touching on his ...
(Date:10/20/2014)... The Advocator Group, LLC is ... Foundation for Suicide Prevention’s (AFSP) Out of the Darkness ... organization that hosts hundreds of community walks throughout the ... used to help understand and prevent suicide through not ... well. , The Advocator Group shares this passion ...
Breaking Medicine News(10 mins):Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 2Health News:U.S. Cameraman Treated for Ebola 'Free' of the Virus 3Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3
... Mass. and SYDNEY, Australia, April 18 ,HeartWare Limited ... to an,expanded, upgraded manufacturing facility in Miami Lakes, ... nearly twice the size of HeartWare,s,current facility, will ... is,expected to meet all of the Company,s operational ...
... 17, 2008) - The Life Sciences Discovery Fund ... to 5 Washington State-based life sciences organizations and ... the areas of medical genetics, autoimmunity, cancer clinical ... (See Backgrounder Information). , The grant awardees are: ...
... 18 Avalon Health Care, Inc. today,announced that the ... has,become the first skilled nursing facility in the state ... the American Association,for Respiratory Care (AARC)., "Earning the ... This achievement reflects Avalon,s overall goal of providing a,higher ...
... Four-legged heroes -- cats, too -- are maintaining the veterinary ... most of America,s blood donors, JJ and Logan are unaware ... saved. , But over a three-year period, the two healthy ... numerous canine patients survive surgeries and illnesses to play "fetch" ...
... house aide,Robert Weiner, and Dr. Patricia Berg, director of ... many scientists believe that "the,cost of the Iraq war ... for,cancer research, and private organizations, though critical, are a ... are being,lost due to "the high funding bar.", ...
... 17 When Wiley Coyote goes,hungry in cartoon ... in the,real world, Roadrunner Food Bank wins when ... (Photo: http://www.newscom.com/cgi-bin/prnh/20080417/LATH545-b ), In that ... Mexico,s Roadrunner Food Bank to highlight the tragedy ...
Cached Medicine News:Health News:HeartWare Announces Move to an Expanded, Upgraded Manufacturing Facility 2Health News:HeartWare Announces Move to an Expanded, Upgraded Manufacturing Facility 3Health News:Life Sciences Fund grants awards to launch health research 2Health News:Life Sciences Fund grants awards to launch health research 3Health News:Life Sciences Fund grants awards to launch health research 4Health News:Life Sciences Fund grants awards to launch health research 5Health News:Woodland Park Care Center Earns Quality Respiratory Care Recognition 2Health News:Donor Dogs Give the Gift of Life 2Health News:Donor Dogs Give the Gift of Life 3Health News:Donor Dogs Give the Gift of Life 4Health News:Reduced Funds for Cancer is Cost of Iraq, Say Ex-White House Aide, Cancer Researchers 2Health News:BEEP BEEP!! Strategic Communications Firm DW Turner Thwarts Hunger in Partnership With Roadrunner Food Bank 2
(Date:10/22/2014)... LA VERNE, Calif. , Oct. 22, 2014 ... emergency readiness products, has developed APLS ® ... bag that minimizes the spread of bacteria and ... APLS Body Guard Bio features a ... and finished edges that create a leak-proof inner ...
(Date:10/22/2014)... 22, 2014  CryoLife, Inc. (NYSE: CRY ... focused on cardiac and vascular surgery, announced today that ... Executive Officer, has been elected to the Company,s Board ... Steven G. Anderson , Executive Chairman of CryoLife, stated, "Since ... be an excellent leader who is well positioned to ...
(Date:10/22/2014)... , Oct. 21, 2014   BioNano Genomics ... latest genomics research centers to purchase an ... the National Cancer Institute (NCI), NIH Intramural Sequencing ... Before Irys, obtaining a comprehensive view of a ... sequencing (NGS) does not deliver the scalability or ...
Breaking Medicine Technology:New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 2BioNano's Irys System Adopted by Leading Genomics Centers for Comprehensive Detection of Human Genome Structural Variation 3
... of Vermillion, Inc. (NASDAQ: VRML ), a leading ... successor to Gail S. Page, president and CEO. The board ... the search by September 2012. James S. Burns, ... led the divestiture of the company,s original research tools business, ...
...  InfuSystem Holdings, Inc. (NYSE MKT:  INFU), the leading national ... healthcare industry, today announced that it will release results ... 2012 following the market close.  The ... May 22, 2012 at 9:00 a.m. Eastern Time.  To ...
Cached Medicine Technology:Vermillion Announces CEO Succession Plan 2Vermillion Announces CEO Succession Plan 3Vermillion Announces CEO Succession Plan 4
... Shandon Cryotome FE and FSE are a ... Electron. The microtome is outside of the ... as well as faster temperature adjustment. Simple, ... Complete temperature controls on the main touch-screen ...
A standard, durable and reliable indirect....
Designed to retain the desired curve during oral intubation....
Facilitates intubation of tracheal tubes....
Medicine Products: