Navigation Links
Cigarette smoke may contribute to lung inflammation through a new chemical pathway
Date:9/2/2010

BIRMINGHAM, Ala. Cigarette smoke shuts off a key enzyme in airways that regulates the body's response to inflammation, according to findings from the University of Alabama at Birmingham published online today at Science Express.

The UAB researchers say smoke inhibits the enzyme, called Leukotriene A4 Hydrolase (LTA4H), causing it to fail in its job of shutting down white blood cells following a successful response to inflammation.

The team says the research study identified a previously unknown substrate of LTA4H called proline-glycine-proline (PGP). In a normal response to inflammation, PGP's role is to recruit neutrophils white blood cells that rush to the scene and attack the cause of the inflammation. When the job is over, LTA4H steps in to shut off PGP, in turn halting the recruitment of neutrophils and ending the body's defensive stand.

"We found, however, that cigarette smoke inhibited LTA4H, preventing it from shutting down PGP," said J. Edwin Blalock, Ph.D., senior author and professor in the UAB Division of Pulmonary, Allergy and Critical Care Medicine. "A continued presence of PGP means a continued response of neutrophils, a never-ending cycle that supports chronic inflammation."

Blalock said PGP is a biomarker for several lung diseases that feature chronic inflammation, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

The study also details a dual role played by LTA4H in suppressing or encouraging inflammation. When contained within a cell, LTA4H has a pro-inflammatory job, generating an agent know as Leukotriene B4 (LTB4), which, much like PGP, calls in the neutrophils when required. However, when LTA4H is found outside of the cell (when the cell it resides in dies, for example) its role switches to an anti-inflammatory one, as it works to suppress PGP and end the body's inflammatory response.

"This dual role was poorly understood until we identified PG
'/>"/>

Contact: Bob Shepard
bshep@uab.edu
205-934-8934
University of Alabama at Birmingham
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
2. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
3. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
4. New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking
5. New Report: $1 Cigarette Tax Increase Would Raise $113.9 Million for Colorado and Cut Youth Smoking
6. New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking
7. Cigars, Pipes No Healthy Alternative to Cigarettes
8. E-Cigarette Maker Green Smoke Tells FDA to Back Off!
9. New Mexico Cigarette Tax Increase Delivers Victory for Kids and Taxpayers, But Increase Needs to Be Permanent
10. Utah Cigarette Tax Increase Delivers Victory for Kids and Taxpayers
11. The Electronic Cigarette Company Challenges the Rt Hon Andy Burnham MP to Ban All Tobacco Products on 21st June 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... 19, 2014 (HealthDay News) -- The U.S. Food and Drug ... Thursday. Trulicity is part of a class of once-a-week injectable ... type 2 diabetes. "Trulicity is a new treatment ... treatment regimens to control blood sugar levels in the overall ... of the FDA,s Office of Drug Evaluation II, said in ...
(Date:9/19/2014)... cells to treat and cure disease is a ... hindered by the inability of doctors and scientists to ... cells in patients without resorting to invasive procedures, like ... in the online journal Magnetic Resonance in Medicine ... School of Medicine, University of Pittsburgh and elsewhere describe ...
(Date:9/19/2014)... Recent two-generation approaches to reducing poverty that help ... from researchers, advocates, and foundations. By combining education ... move to jobs that offer a path out ... for children, these programs aim to improve the ... a new report from the National Center for ...
(Date:9/19/2014)... Sept. 19, 2014 (HealthDay News) -- More states are ... medication epinephrine to use for any child having a ... treatment for "anaphylaxis," an allergic reaction that can lead ... blood pressure and even death. In people ... or tree nuts, insect venom or certain drugs, anaphylaxis ...
(Date:9/19/2014)... 19, 2014 Top 10 Best ... announced that HostGator.com, GoDaddy and Bluehost are among ... companies are the most recommended suppliers for webmasters ... to buy high quality Linux hosting (including VPS ... is one of many top hosting companies that ...
Breaking Medicine News(10 mins):Health News:FDA Approves Another Weekly Injectable Drug for Type 2 Diabetes 2Health News:A better way to track emerging cell therapies using MRIs 2Health News:A two generation lens: Current state policies fail to support families with young children 2Health News:More Schools Stocking Shots That Counter Serious Allergic Reactions 2Health News:More Schools Stocking Shots That Counter Serious Allergic Reactions 3Health News:Top10BestSEOHosting.com Announces Great Linux Web Hosting Suppliers In 2014 2
... REMIND LAWMAKERS CALIFORNIA PREMIUMS ARE 17 PERCENT ... ... At the Assembly,Health Committee,s hearing on Governor Arnold Schwarzenegger,s health ... National Association of Insurance and Financial Advisors-California,(NAIFA-California) urged lawmakers to ...
... 31 Conseco, Inc. (NYSE:,CNO) today reported results for ... reflect a number of significant events, as,progress on our ... increasingly evident," CEO Jim Prieur said. "We saw continued,strong ... businesses, while,Conseco Insurance Group, even with a decline in ...
... Effective ... Alternatives, LOS ... thinking about health and medicine over the past few years as ... As concerns grow regarding conventional, over-the-counter,medicine, Hyland,s homeopathic medicines offer a ...
... Dr. James M. Farrell, a,doctor of chiropractic practicing ... Chiropractic Association (CCA). He was nominated,and chosen by his ... the CCA since 1992, Dr. Farrell has been extremely ... a committee chair, board member,and executive board member prior ...
... Today researchers report a newly identified genetic ... cancer in African American men. This study, which ... prostate cancer in high-risk populations, is published online in ... cancer is the second leading cause of cancer death ...
... feline DNA could help humans, too, scientists say , WEDNESDAY, ... of the domestic cat ( Felis catus ), an advance ... pets and provide an excellent model for human disease. , ... traced back several generations to Sweden, was the subject of ...
Cached Medicine News:Health News:Health Insurance Agents Warn Against Imposing a 'Health Care Reform' Tax in California 2Health News:Health Insurance Agents Warn Against Imposing a 'Health Care Reform' Tax in California 3Health News:Conseco Reports Third Quarter Results 2Health News:Conseco Reports Third Quarter Results 3Health News:Conseco Reports Third Quarter Results 4Health News:Conseco Reports Third Quarter Results 5Health News:Conseco Reports Third Quarter Results 6Health News:Conseco Reports Third Quarter Results 7Health News:Conseco Reports Third Quarter Results 8Health News:Conseco Reports Third Quarter Results 9Health News:Conseco Reports Third Quarter Results 10Health News:Conseco Reports Third Quarter Results 11Health News:Conseco Reports Third Quarter Results 12Health News:Conseco Reports Third Quarter Results 13Health News:Conseco Reports Third Quarter Results 14Health News:Conseco Reports Third Quarter Results 15Health News:Conseco Reports Third Quarter Results 16Health News:Conseco Reports Third Quarter Results 17Health News:Hyland's Inc. Reports More Consumers Turn to Homeopathic Medicines to Fight Illness at Home 2Health News:Golden Doctor of Chiropractic Elected President of the Colorado Chiropractic Association 2Health News:Scientists discover genetic variant associated with prostate cancer in African Americans 2
(Date:9/19/2014)... Sept. 19, 2014 The American Association for ... Design and Manufacturing has joined the AAHomecare Corporate Partner ... Harvey Diamond have been actively involved in AAHomecare ... it has quickly grown into a major global manufacturer ... Drive allows AAHomecare to increase efforts on behalf of ...
(Date:9/19/2014)... UBM Medica US announces that  ... help oncologists and other clinicians gain a better understanding ... targeted therapies and immunotherapies, discusses some of the latest ... Every September, Blood Cancer Awareness Month ... blood cancers—helping to increase survival rates and improve the ...
(Date:9/19/2014)... 2014 Larry J. Merlo , President and ... speak before the National Press Club in Washington, ... move to stop selling tobacco products and its leadership in ... "Dramatic changes in our health care system pose ... Merlo has said. "CVS Health has a truly unique combination ...
Breaking Medicine Technology:Drive Medical Design & Manufacturing Joins AAHomecare Corporate Partner Program 2OncoTherapy Network Highlights National Blood Cancer Awareness Month 2OncoTherapy Network Highlights National Blood Cancer Awareness Month 3OncoTherapy Network Highlights National Blood Cancer Awareness Month 4CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3
... Pharmaceutical Services is pleased to announce the exciting addition ... as the new Manager of Minerals.  Dr. Al-Ammar brings ...  Al-Ammar has over fourteen years of experience with ICP-MS ... the United States and Europe.  Additionally, Dr. Al-Ammar has ...
... MedNet Solutions, a global life sciences technology solutions company ... announce that MedNet will be showcasing its full lineup ... Association (DIA) Annual Meeting in Chicago, IL on June ... release of iMedNet EDC earlier this year, MedNet now ...
Cached Medicine Technology:Dr. Assad Al-Ammar Joins Irvine Pharmaceutical Services as the New Minerals Analysis Manager in Response to the Growing Needs for USP Elemental Impurities Testing 2MedNet Solutions to Showcase Its Complete Suite of eClinical Solutions at the 47th DIA Annual Meeting 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: