Navigation Links
Cigarette smoke may contribute to lung inflammation through a new chemical pathway
Date:9/2/2010

BIRMINGHAM, Ala. Cigarette smoke shuts off a key enzyme in airways that regulates the body's response to inflammation, according to findings from the University of Alabama at Birmingham published online today at Science Express.

The UAB researchers say smoke inhibits the enzyme, called Leukotriene A4 Hydrolase (LTA4H), causing it to fail in its job of shutting down white blood cells following a successful response to inflammation.

The team says the research study identified a previously unknown substrate of LTA4H called proline-glycine-proline (PGP). In a normal response to inflammation, PGP's role is to recruit neutrophils white blood cells that rush to the scene and attack the cause of the inflammation. When the job is over, LTA4H steps in to shut off PGP, in turn halting the recruitment of neutrophils and ending the body's defensive stand.

"We found, however, that cigarette smoke inhibited LTA4H, preventing it from shutting down PGP," said J. Edwin Blalock, Ph.D., senior author and professor in the UAB Division of Pulmonary, Allergy and Critical Care Medicine. "A continued presence of PGP means a continued response of neutrophils, a never-ending cycle that supports chronic inflammation."

Blalock said PGP is a biomarker for several lung diseases that feature chronic inflammation, such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

The study also details a dual role played by LTA4H in suppressing or encouraging inflammation. When contained within a cell, LTA4H has a pro-inflammatory job, generating an agent know as Leukotriene B4 (LTB4), which, much like PGP, calls in the neutrophils when required. However, when LTA4H is found outside of the cell (when the cell it resides in dies, for example) its role switches to an anti-inflammatory one, as it works to suppress PGP and end the body's inflammatory response.

"This dual role was poorly understood until we identified PG
'/>"/>

Contact: Bob Shepard
bshep@uab.edu
205-934-8934
University of Alabama at Birmingham
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New Report: $1 Cigarette Tax Increase Would Raise $418.8 Million for Texas and Cut Youth Smoking
2. New Report: $1 Cigarette Tax Increase Would Raise $18.6 Million for Montana and Cut Youth Smoking
3. New Report: $1 Cigarette Tax Increase Would Raise $24.8 Million for Wyoming and Cut Youth Smoking
4. New Report: $1 Cigarette Tax Increase Would Raise $43.3 Million for Utah and Cut Youth Smoking
5. New Report: $1 Cigarette Tax Increase Would Raise $113.9 Million for Colorado and Cut Youth Smoking
6. New Report: $1 Cigarette Tax Increase Would Raise $65.3 Million for Iowa and Cut Youth Smoking
7. Cigars, Pipes No Healthy Alternative to Cigarettes
8. E-Cigarette Maker Green Smoke Tells FDA to Back Off!
9. New Mexico Cigarette Tax Increase Delivers Victory for Kids and Taxpayers, But Increase Needs to Be Permanent
10. Utah Cigarette Tax Increase Delivers Victory for Kids and Taxpayers
11. The Electronic Cigarette Company Challenges the Rt Hon Andy Burnham MP to Ban All Tobacco Products on 21st June 2010
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... News) -- Complications are rare among breast cancer ... study indicates. However, the researchers did find ... slightly higher risk for certain complications than a ... 18,000 breast cancer patients who had a single ... reconstruction and were followed for 30 days after ...
(Date:9/2/2014)... 2, 2014 In a large population-based study ... that mild cognitive impairment (MCI) occurred twice more ... 2. Interestingly, this strong association was only observed ... participants (66-80 years) the association vanished. This study ... Disease . , The concept of MCI describes ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 Medex ... location of their corporate headquarters in Coral Springs, Fla. ... have exceeded our business development objectives for the 2014 ... Neil Herbst. “Our industry has requested a higher level ... utilization reviews. Medex has delivered, and the industry has ...
(Date:9/2/2014)... Kathleen Doheny HealthDay ... The U.S. obesity epidemic is a driving force behind the ... study. Researchers looked at data from five national surveys ... increase in diabetes over time could be explained by factors ... U.S. adults. The investigators found that the prevalence of ...
(Date:9/2/2014)... -- Melatonin supplements did not reduce delirium in seniors ... found. Many older hospital patients experience the sudden, ... their normal sleep-wake cycle. A lack of the hormone ... but there has been little research into whether melatonin ... 378 patients, average age 84, who had hip fracture ...
Breaking Medicine News(10 mins):Health News:Complication Rates Low With Mastectomy, Breast Reconstruction: Study 2Health News:Diabetes mellitus and mild cognitive impairment: Higher risk in middle age? 2Health News:Medex Analytic Services Announces New Location for Corporate Headquarters 2Health News:Obesity Fueling Rise in Diabetes Rates, Study Finds 2Health News:Obesity Fueling Rise in Diabetes Rates, Study Finds 3
... Minn. -- A Mayo Clinic study of a drug that ... demonstrates that the drug may also be effective in treating ... The study, which was done in mouse models, is featured ... , The National Cancer Institute reports that of 240,510 ...
... physicians not to disclose bad news to ill loved ... be truthful to the patient with the familys belief ... more successfully manage these conflicts, researchers at the University ... at Stanford University, have developed an approach based on ...
... is overweight when she becomes pregnant, the probability is ... when he/she reaches school age, according to a new ... Alina Rodriguez at Uppsala University in collaboration with international ... of Obesity. , The study, comprising more than 12,500 ...
... Global Med Technologies(R),Inc. (OTC Bulletin Board: GLOB), ... presenting at the Acumen Biofin,Rodman & Renshaw 9th ... the New York Palace Hotel in New York ... Tuesday, November 6th, at 11:15 a.m. EST, Dr. ...
... Technologies,Corporation (Nasdaq: DVAX ) announced today Michael S. ... overview of the,company at two investor conferences in New ... at the CIBC World Markets 18th Annual,Healthcare Conference on ... PT). In addition, Ostrach will present at the Acumen ...
... Arete Therapeutics Inc. today,announced the initiation of ... compound,AR9281, for the treatment of hypertension. AR9281 is ... a novel target,for the treatment of hypertension. The ... and will evaluate the safety, tolerability,pharmacokinetics and pharmacodynamics ...
Cached Medicine News:Health News:Mayo Clinic study shows drug could effectively treat, prevent the spread of breast cancer 2Health News:Mayo Clinic study shows drug could effectively treat, prevent the spread of breast cancer 3Health News:Don't tell mother she has cancer 2Health News:Overweight mothers run greater risk of having hyperactive children 2Health News:Global Med Technologies(R) to Present at Rodman & Renshaw 9th Annual Healthcare Conference 2Health News:Dynavax to Present at CIBC World Markets and Acumen BioFin Rodman and Renshaw Healthcare Conferences 2Health News:Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent 2Health News:Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent 3
(Date:9/2/2014)... , Sept. 2, 2014 Reportbuyer.com ... Global Markets and Technologies for Molecular Imaging ... STUDY GOALS AND OBJECTIVES The objectives of ... at molecular imaging devices used for diagnostic purposes, ... market and all possible market segments as well ...
(Date:9/2/2014)... 2, 2014 Reportbuyer.com has added a ... Global Markets for Services and Devices ... Bariatric surgery or weight loss surgery is a ... processes that deal with the surgical treatment of ... (endoluminal) and performed in both open and laparoscopic ...
(Date:9/2/2014)... , Sept. 2, 2014 Astellas has appointed ... intellectual property (IP) in the Americas. Kellerman will report ... & general counsel at Astellas. In his new role, ... partner with the business and manage the region,s intellectual ... "I am very pleased to welcome Jim ...
Breaking Medicine Technology:Global Markets and Technologies for Molecular Imaging Devices 2Global Markets and Technologies for Molecular Imaging Devices 3Global Markets and Technologies for Molecular Imaging Devices 4Global Markets and Technologies for Molecular Imaging Devices 5Global Markets and Technologies for Molecular Imaging Devices 6Global Markets and Technologies for Molecular Imaging Devices 7Global Markets and Technologies for Molecular Imaging Devices 8Global Markets and Technologies for Molecular Imaging Devices 9Global Markets and Technologies for Molecular Imaging Devices 10Global Markets and Technologies for Molecular Imaging Devices 11Global Markets and Technologies for Molecular Imaging Devices 12Global Markets and Technologies for Molecular Imaging Devices 13Global Markets and Technologies for Molecular Imaging Devices 14Global Markets and Technologies for Molecular Imaging Devices 15Global Markets and Technologies for Molecular Imaging Devices 16Global Markets and Technologies for Molecular Imaging Devices 17Global Markets and Technologies for Molecular Imaging Devices 18Global Markets and Technologies for Molecular Imaging Devices 19Global Markets and Technologies for Molecular Imaging Devices 20Global Markets and Technologies for Molecular Imaging Devices 21Global Markets and Technologies for Molecular Imaging Devices 22Global Markets and Technologies for Molecular Imaging Devices 23Global Markets and Technologies for Molecular Imaging Devices 24Global Markets and Technologies for Molecular Imaging Devices 25Bariatric Surgery: Global Markets for Services and Devices 2Bariatric Surgery: Global Markets for Services and Devices 3Bariatric Surgery: Global Markets for Services and Devices 4Bariatric Surgery: Global Markets for Services and Devices 5Bariatric Surgery: Global Markets for Services and Devices 6Bariatric Surgery: Global Markets for Services and Devices 7Bariatric Surgery: Global Markets for Services and Devices 8Bariatric Surgery: Global Markets for Services and Devices 9Bariatric Surgery: Global Markets for Services and Devices 10Bariatric Surgery: Global Markets for Services and Devices 11Bariatric Surgery: Global Markets for Services and Devices 12
... April 26, 2012  Nurses and future nurses are using smartphones ... tools. A recent survey of nearly 4,000 nurses and nursing ... mobile technology to help them provide efficient and effective care. ... top-selling Nursing 2013 Drug Handbook , the survey found ...
... IDTA) CEO Yaacov Shoham today issued the following statement, ... files and asked them to upgrade IDenta,s current tier. They ... 1. Annual financial report (audited) for year 2011 ... Disclosure Statement The files can be found at ...
Cached Medicine Technology:As Smartphone Usage Expands, Survey Says Nurses and Nursing Students Want Mobile Access to Credible Drug Data 2International Drug & Explosives Detection Company IDenta Corp. Releases Information to OTC markets. 2
... Spinal Implant system. Material that has a ... bone. The result is an implant that ... support, while optimizing the fusion environment through ... anatomic design with 5 and 10 degrees ...
Cervical distraction screw retractor blade with Casper style distractor...
... Panther Retractor is two system in ... use for all cervicle spine retraction ... aluminium facilitate soft tissue retraction and ... intra-operative imaging with minimal interference. Two ...
Cloward cervical retractor. Size 18 mm....
Medicine Products: