Navigation Links
Cialis May Help Ease Pulmonary Hypertension
Date:10/28/2008

Once-daily dose of the ED drug delayed disease progression, researchers found

WEDNESDAY, Oct. 29 (HealthDay News) -- Cialis (tadalafil), a drug used to treat erectile dysfunction, appears effective in treating pulmonary hypertension, researchers report.

Pulmonary hypertension is caused by high blood pressure in the arteries that supply the lungs with blood. People who suffer from the condition can become tired, dizzy and short of breath, because the arteries feeding the lungs constrict and reduce the supply of oxygenated blood being circulating throughout the body.

But Cialis "was found to improve exercise capacity, health-related quality of life, delay time to clinical worsening, and improve hemodynamic [blood-linked] parameters of disease severity," said lead researcher Dr. Robyn J. Barst, a professor of pediatrics at Columbia University College of Physicians & Surgeons in New York City. The drug was also well-tolerated, she added.

The report was to be presented Tuesday at the American College of Chest Physicians annual meeting, in Philadelphia.

For the study, Barst's team randomly assigned 405 pulmonary hypertension patients to Cialis or placebo once a day, or to Cialis and bosentan (Tracleer) a common treatment for pulmonary hypertension.

The researchers found that over 16 weeks, Cialis increased patients' six-minute walk distance and delayed their time to clinical worsening, which included death, hospitalizations, worsening functional class and the need for adding new pulmonary arterial hypertension therapy.

In addition, Cialis increased heart output and reduced pulmonary artery pressures compared with those measures at the start of the trial, Barst's group found.

"We would anticipate that tadalafil will be reviewed and approved by the regulatory agencies as an additional therapy available for the treatment of pulmonary hypertension," Barst said. "It is useful for the treatment for pulmonary hypertension, as for many other diseases, to have more than one drug per class approved, due to individual patient responses and side effects," she added.

Dr. Gregg C. Fonarow, a professor of cardiology at the University of California, Los Angeles, noted that pulmonary hypertension is a progressive disease which results in substantial morbidity and mortality.

"Prior studies have shown that the oral phosphodiesterase type 5 inhibitor, sildenafil (Viagra, Revatio) improves exercise capacity in patients with pulmonary arterial hypertension," Fonarow said. "This medication is currently FDA-approved for this indication, but must be taken three times daily."

This new study of Cialis, taken once daily, demonstrates that the drug substantially improves functional capacity, improves quality of life, and also results in less clinical worsening in patients with pulmonary arterial hypertension, Fonarow said.

"These are impressive findings," Fonarow said. "Tadalafil represents a very promising new therapy for patients with pulmonary arterial hypertension, that may be used alone or in combination with other treatments such as bosentan."

More information

For details on pulmonary hypertension, visit the American Heart Association.



SOURCES: Robyn J. Barst, M.D., professor, pediatrics, Columbia University College of Physicians & Surgeons, New York City; Gregg C. Fonarow, M.D., professor, cardiology, University of California, Los Angeles; Oct. 28, 2008, presentations, American College of Chest Physicians annual meeting, Philadelphia


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Midwest NeuroSurgery & Spine Specialists Chooses Intergy EHR by Sage
2. South Carolina Veterinary Specialists Installs State-of-the-Art Eklin Digital Practice(R) Technology
3. NeoVista Presents Anatomic Outcomes of Novel Wet AMD Therapy at 2008 American Society of Retina Specialists Meeting
4. First CyberKnife in Saudi Arabia to be Installed at Prestigious King Faisal Specialist Hospital and Research Center
5. Dr. Joel Aronowitz, Specialist in Los Angeles Body Lift, Announces Plastic Surgery Options After Bariatric Surgery Weight Loss
6. Whos Who Weight Specialist Martin Schiff, M.D., 86, Devoting Rest of Life to Spreading Truth About Diets, Wont Accept Compensation From Anyone, Sending Complete Guide Free to All
7. Florida Dentist Launches Revolutionary Solution to National Dental Specialist/Patient Care Dilemma
8. California Supreme Court Gay-Marriage Ruling Reinforces Top Bay Area Fertility Specialists Support for Same-Sex Couples
9. InsuranceSpecialists.com Looks at the Candidates and Health Reform
10. Central Bucks Specialists, a Cardiology and Gastroenterology Multi-location Clinic, Selects MxSecure, Inc., Provider of Medical Transcription Services, as their Transcription Provider.
11. Commentary in The Lancet on the Declaration of Istanbul Sees Organ Transplantation Worldwide Threatened by Organ Trafficking and Transplant Tourism and Commercialism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cialis May Help Ease Pulmonary Hypertension
(Date:12/9/2016)... ... 09, 2016 , ... Groth Family Insurance, a Washington-based firm ... initiating a charity drive to support the family of Cindy Hendrickson, a local ... , On October 29th of this year, Cindy Hendrickson swerved to avoid an ...
(Date:12/9/2016)... ... 09, 2016 , ... "I have gout, and I wanted to treat it ... is meant to relieve gout and pain caused by varicose veins. I drank it ... time. It relieved what VA doctors called the worst sinusitis case they'd seen and ...
(Date:12/9/2016)... ... 2016 , ... An inventor from Cana, Va., wanted to fulfill the need ... park rides. , The patent-pending SAFETY STRAP FOR AMPUTEES improves accessibility. It eliminates discrimination. ... set up in a matter of minutes, or even seconds. The SAFETY STRAP FOR ...
(Date:12/9/2016)... ... December 09, 2016 , ... MEDI+SIGN®, a provider of fully-automated ... new solution for Emergency Departments (ED) has been added to their portfolio. Housed ... examination rooms, and with a simplified pallet of information available to the patient, ...
(Date:12/8/2016)... ... 2016 , ... The West Virginia Medical Institute (WVMI) announced ... name change aligns the entire company with its existing Quality Insights branded projects ... are very proud of the achievements associated with the West Virginia Medical Institute ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... KEY FINDINGS The global medical ... Various reasons for growth of the medical lifting sling ... chronic diseases, high recovery cost of injuries and government ... lifting sling refers to an assistive device that helps ... connect to the lift and hold the patient. It ...
(Date:12/8/2016)... , Dec. 8, 2016  Eli Lilly and ... results of its phase 3 EXPEDITION3 trial at the ... meeting. As previously disclosed, solanezumab did not meet the ... of solanezumab initiated in people with mild dementia due ... regulatory submissions for solanezumab for the treatment of mild ...
(Date:12/8/2016)... 2016   TriNetX , the health research ... signed a membership agreement to join the ... new cures. The TriNetX network is ... patients globally, biopharmaceutical companies and contract research organizations ... design, site selection, patient recruitment, and collaborative research ...
Breaking Medicine Technology: