Navigation Links
Cialis May Help Ease Pulmonary Hypertension
Date:10/28/2008

Once-daily dose of the ED drug delayed disease progression, researchers found

WEDNESDAY, Oct. 29 (HealthDay News) -- Cialis (tadalafil), a drug used to treat erectile dysfunction, appears effective in treating pulmonary hypertension, researchers report.

Pulmonary hypertension is caused by high blood pressure in the arteries that supply the lungs with blood. People who suffer from the condition can become tired, dizzy and short of breath, because the arteries feeding the lungs constrict and reduce the supply of oxygenated blood being circulating throughout the body.

But Cialis "was found to improve exercise capacity, health-related quality of life, delay time to clinical worsening, and improve hemodynamic [blood-linked] parameters of disease severity," said lead researcher Dr. Robyn J. Barst, a professor of pediatrics at Columbia University College of Physicians & Surgeons in New York City. The drug was also well-tolerated, she added.

The report was to be presented Tuesday at the American College of Chest Physicians annual meeting, in Philadelphia.

For the study, Barst's team randomly assigned 405 pulmonary hypertension patients to Cialis or placebo once a day, or to Cialis and bosentan (Tracleer) a common treatment for pulmonary hypertension.

The researchers found that over 16 weeks, Cialis increased patients' six-minute walk distance and delayed their time to clinical worsening, which included death, hospitalizations, worsening functional class and the need for adding new pulmonary arterial hypertension therapy.

In addition, Cialis increased heart output and reduced pulmonary artery pressures compared with those measures at the start of the trial, Barst's group found.

"We would anticipate that tadalafil will be reviewed and approved by the regulatory agencies as an additional therapy available for the treatment of pulmonary hypertension," Barst said. "It is useful for the treatment for pulmonary hypertension, as for many other diseases, to have more than one drug per class approved, due to individual patient responses and side effects," she added.

Dr. Gregg C. Fonarow, a professor of cardiology at the University of California, Los Angeles, noted that pulmonary hypertension is a progressive disease which results in substantial morbidity and mortality.

"Prior studies have shown that the oral phosphodiesterase type 5 inhibitor, sildenafil (Viagra, Revatio) improves exercise capacity in patients with pulmonary arterial hypertension," Fonarow said. "This medication is currently FDA-approved for this indication, but must be taken three times daily."

This new study of Cialis, taken once daily, demonstrates that the drug substantially improves functional capacity, improves quality of life, and also results in less clinical worsening in patients with pulmonary arterial hypertension, Fonarow said.

"These are impressive findings," Fonarow said. "Tadalafil represents a very promising new therapy for patients with pulmonary arterial hypertension, that may be used alone or in combination with other treatments such as bosentan."

More information

For details on pulmonary hypertension, visit the American Heart Association.



SOURCES: Robyn J. Barst, M.D., professor, pediatrics, Columbia University College of Physicians & Surgeons, New York City; Gregg C. Fonarow, M.D., professor, cardiology, University of California, Los Angeles; Oct. 28, 2008, presentations, American College of Chest Physicians annual meeting, Philadelphia


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Midwest NeuroSurgery & Spine Specialists Chooses Intergy EHR by Sage
2. South Carolina Veterinary Specialists Installs State-of-the-Art Eklin Digital Practice(R) Technology
3. NeoVista Presents Anatomic Outcomes of Novel Wet AMD Therapy at 2008 American Society of Retina Specialists Meeting
4. First CyberKnife in Saudi Arabia to be Installed at Prestigious King Faisal Specialist Hospital and Research Center
5. Dr. Joel Aronowitz, Specialist in Los Angeles Body Lift, Announces Plastic Surgery Options After Bariatric Surgery Weight Loss
6. Whos Who Weight Specialist Martin Schiff, M.D., 86, Devoting Rest of Life to Spreading Truth About Diets, Wont Accept Compensation From Anyone, Sending Complete Guide Free to All
7. Florida Dentist Launches Revolutionary Solution to National Dental Specialist/Patient Care Dilemma
8. California Supreme Court Gay-Marriage Ruling Reinforces Top Bay Area Fertility Specialists Support for Same-Sex Couples
9. InsuranceSpecialists.com Looks at the Candidates and Health Reform
10. Central Bucks Specialists, a Cardiology and Gastroenterology Multi-location Clinic, Selects MxSecure, Inc., Provider of Medical Transcription Services, as their Transcription Provider.
11. Commentary in The Lancet on the Declaration of Istanbul Sees Organ Transplantation Worldwide Threatened by Organ Trafficking and Transplant Tourism and Commercialism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cialis May Help Ease Pulmonary Hypertension
(Date:5/27/2016)... ... ... With a team of certified experts, Validation Center is ... GMP accreditation, Validation Center is also a registered authority of the international system ... Validation Center is ISO17025 accredited and only offers its clients the latest technology, ...
(Date:5/26/2016)... ... 2016 , ... W.S. Badger Co. Inc ., the maker of certified ... Work Works Award for its use of effective workplace strategies to increase business and ... administered by the Families and Work Institute (FWI) and the Society for Human Resource ...
(Date:5/26/2016)... Atlanta, Georgia (PRWEB) , ... May 26, 2016 ... ... a certificate in intellectual property (IP) to its specialty academic programs. , Answering ... joins the college’s existing certificate programs in health law, and environmental and land ...
(Date:5/26/2016)... ... 2016 , ... The Woodlands at John Knox Village , Florida’s first ... for living and healing, celebrated its grand opening, today. The Woodlands at John Knox ... by Empowered Staff. , “This is an incredibly fulfilling time for John Knox Village ...
(Date:5/26/2016)... ... May 26, 2016 , ... MadgeTech will be showcasing its ... manufactured in Warner, New Hampshire at the MadgeTech headquarters. With products sold in more ... trusted by government agencies, including NASA. , In 2012, NASA strategically set up ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 ... & Expo earlier this month, the numbers and momentum ... continue to climb into the billions, more research and ... released 4th Edition State of Legal Marijuana Markets Report ... cannabis-focused data-analysis firm, much of the increase in sector ...
(Date:5/25/2016)... ReportsnReports.com adds "Chronic Cough ... provides an overview on therapeutic pipeline of Chronic ... therapeutics assessment by drug target, mechanism of action ... along with latest updates, and featured news and ... in the therapeutic development for Chronic Cough and ...
(Date:5/24/2016)... HENDERSON, Nev. , May 24, 2016  Diana ... painfully "eats" her organs from the inside out.  This ... her completely dependent on her children and grandchildren to ... of her wheelchair, Diana,s family cannot haul the wheelchair.  ... rides in the car, and Diana is left to ...
Breaking Medicine Technology: