Navigation Links
Chronic stress of cancer causes accelerated telomere shortening
Date:4/2/2011

ORLANDO, Fla. Results of a study presented at the AACR 102nd Annual Meeting 2011, held here April 2-6, lend credence to the idea that improving quality of life affects stress-related biological markers and possibly the health of people with cancer.

Researchers know that telomeres shorten and deteriorate with aging, but they are learning that stress also affects telomere length.

"We are trying to understand the interconnections between the mind and the body; that is, how does the diagnosis and treatment of cancer impact patients not only psychologically, but also physiologically and how can we improve their outcome. Cancer drives a chronic stress response in some patients," said Edward Nelson, M.D., division chief of hematology/oncology at the University of California, Irvine.

Just as aglets prevent a shoelace from unraveling or fraying, telomeres are structures on the ends of chromosomes that protect the chromosome from deteriorating, breaking apart or joining with other chromosomes, which can lead to mutations. Chromosomal rearrangements are seen in cancers and provided a biological reason to investigate this link, according Nelson.

"For this study, we wanted to know if chronic stress was associated with accelerated telomere shortening in cancer patients, and if a psychosocial intervention that modulates the stress response could also modulate telomere length," he said.

In this retrospective study, the researchers took biological samples from 31 women with cervical cancer who had been randomized to one of two groups those who received six counseling sessions by telephone and those who received usual care without counseling.

The six sessions consisted of a quality of life and psychosocial profile, managing stress and emotions, enhancing health and wellness, addressing relational and sexual concerns, and integrating and summarizing the information. At enrollment and after four months, the researchers obtained biological samples from both groups and investigated changes over time to see if psychological counseling had any physical effects.

"Improved quality of life and reduced stress response was associated with changes in telomere length," Nelson said.

"It is important to recognize that this was an exploratory and preliminary analysis. We embarked on the first study of telomere length and chronic stress in a cancer population and the first longitudinal analysis in whether changes in quality of life and changes in the stress response would be associated with modulating the telomere length," he said.

Still, he added, "there is no doubt that offering psychological services has the potential to improve quality of life and outcomes of patients. After all, making patients feel better should be an outcome that a cancer team should want to have, but whether we can draw conclusions or make recommendations about the capacity of a behavioral intervention to modulate telomere length remains an open question."

This abstract will be presented at an AACR press conference on Saturday, April 2 at 2:00 p.m. ET in room W313 of the Orange County Convention Center. Reporters who cannot attend in person can participate using the following information:

  • U.S. & Canada: (888) 647-7462
  • International: (201) 604-0169
  • Access Code: 244081


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Study reveals no impact of age on outcome in chronic myeloid leukemia patients treated with imatinib
2. Older lesbians, gays have higher rates of chronic disease, mental distress, isolation
3. Chronic Pain Often Follows Car Crash: Study
4. Traffic accidents linked to increased risk of chronic widespread pain
5. Whether Chronic Diseases Are Diagnosed May Depend on Where You Live
6. Contrary to popular belief, not all cases of chronic pancreatitis are alcohol-induced
7. Americans have higher rates of most chronic diseases than same-age counterparts in England
8. UC Davis pain research may pave the way to understanding and controlling chronic pain
9. The safety of daily magnesium oxide treatment for children with chronic constipation
10. Spinal Fluid May Hold Clues to Lyme Disease, Chronic Fatigue Syndrome
11. Study Unravels Link Between Stress and Chronic Health Issues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... 2016 , ... In a new paper published in the ... Rod J. Rohrich, and colleagues, examine and underscore the importance of upper lateral ... when addressing this vital area. , The upper lateral cartilage in rhinoplasty, refers ...
(Date:2/11/2016)... Mount Laurel, NJ (PRWEB) , ... February 11, ... ... Commission) announces the call for nominations seeking candidates for the Board of Commissioners. ... individuals with passion, skills and experience with diversity of clinical practice settings and ...
(Date:2/11/2016)... ... February 11, 2016 , ... Life is known for throwing curves. It’s thrown ... who gather once a year to play softball to raise money through Sun ... more than 50 players who competed in this year’s softball tournament share a history ...
(Date:2/11/2016)... ... February 11, 2016 , ... AccuVein Inc. announces the Infusion ... of Practice, to include vascular visualization as a standard practice. AccuVein ( http://www.accuvein.com ... the market, facilitates adherence to this standard with its easy to use, widely ...
(Date:2/11/2016)... ... 11, 2016 , ... Dickinson Insurance & Financial Services continues their commitment to ... support of a local boy named Barrett, who has been fighting ALL leukemia for ... rally support for, all local families dealing with childhood cancer. Information on how to ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... , Maharashtra, February 12, 2016 ... Market research report titled Chronic Inflammation Global Clinical ... a snapshot of the global clinical trials landscape ... clinical trials by Region, Country (G7 & E7), ... point status and reviews top companies involved and ...
(Date:2/11/2016)... , Feb. 11, 2016 The primary ... and future adoption patterns on the usage of liquid ... the following: - Timeframe of liquid biopsy ... ctDNA, cfDNA and Evs—by organization type - Sample inflow ... types: blood, saliva, stool, serum, and so on. - ...
(Date:2/11/2016)... 2016 PRO-DEX, INC. (NasdaqCM: PDEX) today announced financial ... 2015. The Company also filed its Quarterly Report on Form ... the Securities and Exchange Commission today. --> ... --> --> Net sales for ... or 95%, to $5.4 million from $2.8 million for the ...
Breaking Medicine Technology: