Navigation Links
Chronic pain treatments work better together, says anesthesiologist
Date:9/30/2009

Kingston, ON People who suffer from debilitating neuropathic pain may get more relief and sleep better by combining two commonly-prescribed drugs.

A new, federally-funded study by Queen's University researchers has found that taking the drugs together is a more effective treatment than taking either of them individually.

When given both an anti-seizure drug (gabapentin) and an antidepressant (nortriptyline), patients suffering from neuropathic pain caused by nerve damage or disease experienced less pain than when they took one or the other individually, reports Ian Gilron, director of Clinical Pain Research for Queen's Departments of Anesthesiology, and Pharmacology & Toxicology, and an anesthesiologist at Kingston General Hospital.

"It was also exciting to discover the effect of this combination on sleep interference," adds Dr. Gilron, noting that people rated sleep interference with the combined drugs as 1.0 on a scale of 10, compared to 2.2 when they took each drug individually. "That's a very important issue for this group of patients, whose debilitating, unrelenting pain often interferes with normal sleep."

This is the first time Dr. Gilron has been able to find a drug combination that also helps patients sleep better. An earlier trial investigated the effects of combining morphine the other type of commonly prescribed drug for neuropathic pain with the anti-seizure drug gabapentin. The patients' pain lessened significantly, but they still had as much trouble sleeping.

Dr. Gilron says it's important to understand how drugs interact, since 45 per cent of Canadians being treated for neuropathic pain take two or more pain drugs. There may also be safety issues. "We need more evidence from carefully conducted trials in support of each particular combination, and let the doctors and patients know about such results," Dr. Gilron stresses.

While this research focuses on two specific types of neuropathic pain diabetic neuropathy and postherpetic neuralgia the methodology could also be applied to the study of other chronic conditions such as cancer-related pain, spinal disk disease, and the pain experienced after chemotherapy and mastectomies, says Dr. Gilron.

Results of the study, funded by the Canadian Institutes of Health Research (CIHR), are published today in the international health journal, The Lancet.

"This is a very interesting and important result," says Dr. Jane Aubin, Scientific Director of CIHR's Institute of Musculoskeletal Health and Arthritis. "Many chronic pain sufferers don't sleep well, and they get caught in a vicious cycle in which less sleep equals more pain. Dr. Gilron's work offers new hope to Canadians desperate to put an end to this debilitating situation."


'/>"/>

Contact: Nancy Dorrance
nancy.dorrance@queensu.ca
613-533-2869
Queen's University
Source:Eurekalert

Related medicine news :

1. Researchers develop an integrated treatment for veterans with chronic pain and posttraumatic stress
2. Cost Savings Adds to Value of Preventing Chronic Disease
3. Drug-eluting stents safe, effective for treatment of chronic total occlusions
4. K-State biologist to further study of cellular process that plays role in chronic disease
5. Mayo Clinic researchers lead national trial testing new treatment for chronic, severe indigestion
6. Health staff and relatives underestimate chronic pain experienced by nursing home residents
7. Combat Exposure Tied to Chronic High Blood Pressure
8. Two Treatments Equally Effective for Chronic Pelvic Pain
9. AUDIO from Medialink, Boehringer Ingelheim Pharmaceuticals, Inc. & Pfizer Inc.: Coping with Chronic Obstructive Pulmonary Disease (COPD)
10. A Wound that Does Not Heal: Frost & Sullivan Reveals the Impact of Chronic Ulcers on the European Healthcare System
11. Chronic Media Multi-Tasking Makes It Harder to Focus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2017)... DIEGO, California (PRWEB) , ... June 20, 2017 ... ... product documentation and help content solutions for the enterprise, is proud to announce ... properties, including CRM, e-commerce, ticketing systems, company websites, and more to provide a ...
(Date:6/20/2017)... Cincinnati, Ohio (PRWEB) , ... June 20, 2017 ... ... with gum disease in Cincinnati, OH for leading-edge care, whether or ... advances in laser dentistry. Using the BIOLASE WaterLase® iPlus™ laser, she targets bacteria ...
(Date:6/20/2017)... ... June 20, 2017 , ... With certifications and experience ... in Denville, NJ, Drs. Adam and Hal Kimowitz are currently accepting new patients at ... traditional orthodontics can cause for some patients, which is why they offer the latest ...
(Date:6/20/2017)... ... June 20, 2017 , ... This year, participants ... focused on finding product improvements that could reduce the occurrence of unplanned extubations ... need help breathing or to provide medication. Sometimes, patient movement can cause unplanned ...
(Date:6/20/2017)... , ... June 20, 2017 , ... ... makers of SweetLeaf® Stevia Sweetener, Michael P. May, Ph.D., recently accepted the distinguished ... Export Recognition Program selected Wisdom Natural Brands (WNB), and 16 other businesses from ...
Breaking Medicine News(10 mins):
(Date:6/12/2017)... June 12, 2017 Kineta, Inc., a biotechnology company ... Kineta Vice President of R&D and Head of Virology ... Pandemic Preparedness for the Northwest and Beyond meeting sponsored ... June 14, 2017 from 8:30-10:30 AM PDT at the Agora ... Dr. Bedard will be joined by other leaders ...
(Date:6/8/2017)... Fla. , June 8, 2017  Less than ... that hit more than 200,000 companies, including hospital networks, ... being heralded as one of the largest online extortion ... in the healthcare market, it is imperative that providers ... protect their data from this — and many other ...
(Date:6/7/2017)... June 6, 2017  Diplomat Specialty Infusion Group, a brand of ... to its Iowa location. The ... now features an ISO 7 cleanroom—the standard needed to compound ... a low level of pollutants. ... consumers and better serve our Iowa patients," ...
Breaking Medicine Technology: