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Chronic pain treatments work better together, says anesthesiologist
Date:9/30/2009

Kingston, ON People who suffer from debilitating neuropathic pain may get more relief and sleep better by combining two commonly-prescribed drugs.

A new, federally-funded study by Queen's University researchers has found that taking the drugs together is a more effective treatment than taking either of them individually.

When given both an anti-seizure drug (gabapentin) and an antidepressant (nortriptyline), patients suffering from neuropathic pain caused by nerve damage or disease experienced less pain than when they took one or the other individually, reports Ian Gilron, director of Clinical Pain Research for Queen's Departments of Anesthesiology, and Pharmacology & Toxicology, and an anesthesiologist at Kingston General Hospital.

"It was also exciting to discover the effect of this combination on sleep interference," adds Dr. Gilron, noting that people rated sleep interference with the combined drugs as 1.0 on a scale of 10, compared to 2.2 when they took each drug individually. "That's a very important issue for this group of patients, whose debilitating, unrelenting pain often interferes with normal sleep."

This is the first time Dr. Gilron has been able to find a drug combination that also helps patients sleep better. An earlier trial investigated the effects of combining morphine the other type of commonly prescribed drug for neuropathic pain with the anti-seizure drug gabapentin. The patients' pain lessened significantly, but they still had as much trouble sleeping.

Dr. Gilron says it's important to understand how drugs interact, since 45 per cent of Canadians being treated for neuropathic pain take two or more pain drugs. There may also be safety issues. "We need more evidence from carefully conducted trials in support of each particular combination, and let the doctors and patients know about such results," Dr. Gilron stresses.

While this research focuses on two specific types of neuropathic pa
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Contact: Nancy Dorrance
nancy.dorrance@queensu.ca
613-533-2869
Queen's University
Source:Eurekalert

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