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Chronic inflammation may be linked to aggressive prostate cancer
Date:4/17/2014

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Between 1993 and 1997, 18,882 men who were at least 55 years old and had a normal DRE with a serum PSA of 3 ng/ml or less, were recruited to the PCPT. All participants completed questionnaires that included demographics, lifestyle, and medical factors, and were followed for seven years after they were randomly assigned to receive either finasteride or placebo.

The investigators screened all participants for prostate cancer by PSA and DRE during annual visits. Those who had an indication underwent a "for-cause" biopsy if they had cancer, and those who did not have prostate cancer diagnosed during the trial were recommended to undergo an "end-of-study" biopsy at the end of the trial even if they did not have an indication.

From the placebo arm of this study, Platz and colleagues sampled 191 prostate cancer cases and 209 frequency-matched controls for whom biopsy tissue was available. They performed histopathological evaluation of the biopsy samples to identify the prevalence and extent of inflammation, and types of inflammation, i.e., acute or chronic inflammation.

They found that 86.2 percent of cases and 78.2 percent of controls had at least one biopsy core with inflammation, most of which was chronic, and this difference was statistically significant. They also found that the association between chronic inflammation and aggressive prostate cancer did not change after adjusting for known risk factors including body-mass index, pack-years of cigarettes smoked, and history of diabetes.

In addition, this association held true even among men whose PSA levels were less than 2 ng/mL. "We detected chronic inflammation in prostate tissue of men who had prostate cancer but had PSA levels lower than 2 ng/ml, and thus our work supports an association between inflammation and prostate cancer that is not explained by PSA-associated detection bias," said Platz.

Among men whose PSA levels were less than 2 ng/ml at the time of bi
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Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

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