Navigation Links
Chronic inflammation may be linked to aggressive prostate cancer
Date:4/17/2014

>

Between 1993 and 1997, 18,882 men who were at least 55 years old and had a normal DRE with a serum PSA of 3 ng/ml or less, were recruited to the PCPT. All participants completed questionnaires that included demographics, lifestyle, and medical factors, and were followed for seven years after they were randomly assigned to receive either finasteride or placebo.

The investigators screened all participants for prostate cancer by PSA and DRE during annual visits. Those who had an indication underwent a "for-cause" biopsy if they had cancer, and those who did not have prostate cancer diagnosed during the trial were recommended to undergo an "end-of-study" biopsy at the end of the trial even if they did not have an indication.

From the placebo arm of this study, Platz and colleagues sampled 191 prostate cancer cases and 209 frequency-matched controls for whom biopsy tissue was available. They performed histopathological evaluation of the biopsy samples to identify the prevalence and extent of inflammation, and types of inflammation, i.e., acute or chronic inflammation.

They found that 86.2 percent of cases and 78.2 percent of controls had at least one biopsy core with inflammation, most of which was chronic, and this difference was statistically significant. They also found that the association between chronic inflammation and aggressive prostate cancer did not change after adjusting for known risk factors including body-mass index, pack-years of cigarettes smoked, and history of diabetes.

In addition, this association held true even among men whose PSA levels were less than 2 ng/mL. "We detected chronic inflammation in prostate tissue of men who had prostate cancer but had PSA levels lower than 2 ng/ml, and thus our work supports an association between inflammation and prostate cancer that is not explained by PSA-associated detection bias," said Platz.

Among men whose PSA levels were less than 2 ng/ml at the time of bi
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Chronic inflammation linked to high-grade prostate cancer
2. Vibration may help heal chronic wounds
3. Dartmouth researchers develop new approach to chronic lymphocytic leukemia treatment
4. Early detection helps manage a chronic graft-vs.-host disease complication
5. Chronic neck pain common among car crash victims, but most dont sue
6. Women’s Excellence in Endometriosis Now Offering Specialized Care for Chronic Pelvic Pain, Painful Intercourse, and Pain Periods, at Newest Location in Birmingham, MI
7. Performance Rehabilitation and Integrated Medicine in Watchung, NJ Introduces Platelet-Rich Plasma Therapy for Treatment of Chronic Pain
8. Role of chronic medical conditions in readmissions
9. Life Insurance for Seniors and the Importance of Preventing Chronic Diseases
10. Do sports concussions really cause chronic traumatic encephalopathy?
11. Living with chronic pain: The daily struggle with a new self
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... Modoc National Forest, to Ahjumawi Lava Springs, California’s northernmost and among its least ... largest untapped ground water aquifers, whose main outflow is at Ahjumawi Lava Springs, ...
(Date:8/3/2015)... ... August 03, 2015 , ... A July 13 article from ... Cells Found to Release Natural Painkiller That Can Last 'For Five Weeks'" discusses ... the report, the new study showed that harvesting stem cell-rich bone marrow from the ...
(Date:8/3/2015)... AZ (PRWEB) , ... August 03, 2015 , ... Dignity ... Dignity Health Arizona General Hospital Emergency Room – Gilbert, opening in August. The ... earlier this year in the West Valley. , “Dr. Baldwin is an excellent ...
(Date:8/3/2015)... Ore. (PRWEB) , ... August 03, 2015 , ... ... of Government Programs, with accountability for overall performance of the company’s Medicare and ... key focus of Cambia’s strategy to deliver better health for members. In this ...
(Date:8/3/2015)... ... August 03, 2015 , ... The American Institute ... an agreement to collaborate across a wide range of initiatives ranging from code ... among architects. , “Our combined membership, consisting of practicing design professionals, code officials, ...
Breaking Medicine News(10 mins):Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 2Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 3Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 4Health News:Los Angeles Spine Surgeon Gives Insight into How Stem Cells Can Relieve Back Pain 2Health News:Los Angeles Spine Surgeon Gives Insight into How Stem Cells Can Relieve Back Pain 3Health News:Dignity Health Names Dr. Norris A. Baldwin, Jr. Facility Medical Director of New Freestanding Emergency Room 2Health News:Dignity Health Names Dr. Norris A. Baldwin, Jr. Facility Medical Director of New Freestanding Emergency Room 3Health News:Cambia Health Solutions Names Scott Powers President of Government Programs 2Health News:Architects, International Code Council Ink Five-Year Collaborative Agreement 2Health News:Architects, International Code Council Ink Five-Year Collaborative Agreement 3
... , DETROIT, Aug. 21 Blue Cross Blue Shield of Michigan has sent a letter to ... complete text of the letter follows: , , , August 20, 2009 ... Congressman Sander M. Levin, 19855 West Outer Drive ... Roseville, MI 48066, ...
... Heavy use linked to occasional headaches, small jolt tied to ... News) -- Caffeine, known to help alleviate headaches, may cause ... of a study of more than 50,483 people who were ... of the 1995-1997 Nord-Trondelag Health Survey (HUNT 2) in Norway. ...
... , Lease Will Give VA ... WASHINGTON, Aug. 21 Secretary of Veterans Affairs Eric K. Shinseki ... leasing 2.4 acres to a private-sector medical facility in exchange for construction ... at its Samuel S. Stratton VA Medical Center. , , ...
... , ATLANTA, Aug. 21 Veracity Payment ... the newest member in the Bequest(TM) affinity program. Bequest is ... a community level to provide local veterinarians access to on-demand ... their pet,s health care. The Bequest product enables veterinarians ...
... , CHICAGO, Aug. 21 Illinois U.S. Senate ... absolutely critical to achieve the dual goals of containing costs and ... Americans. , , Jackson said that health care ... to choose a national public plan that competes with the private ...
... , , , ... K.C. Clark, a complex rehab specialist with eight years of ... an accredited, national complex rehab company. Clark is an ... for ASM (www.alliance-seating.com) to provide adult and pediatric manual and ...
Cached Medicine News:Health News:Blue Cross Blue Shield of Michigan Releases Letter Sent to Congressmen John Dingell and Sander Levin 2Health News:Blue Cross Blue Shield of Michigan Releases Letter Sent to Congressmen John Dingell and Sander Levin 3Health News:Blue Cross Blue Shield of Michigan Releases Letter Sent to Congressmen John Dingell and Sander Levin 4Health News:High-Octane Caffeine May Trigger Headaches 2Health News:BluePearl Veterinary Partners Joins Bequest(TM) to Help Frankie's Friends Save Pets With Cancer 2Health News:BluePearl Veterinary Partners Joins Bequest(TM) to Help Frankie's Friends Save Pets With Cancer 3Health News:U.S. Senate Candidate Cheryle Jackson: 'Public Option Critical to Real Health Care Reform' 2Health News:Rehab Specialist, K.C. Clark, Joins Alliance Seating & Mobility in Washington 2
(Date:7/31/2015)... , July 31, 2015  Boston Children,s ... benefiting from 3D printing of their anatomy before ... life-threatening cerebrovascular malformations (abnormalities in the brain,s blood ... Reporting online today in the Journal of ... of 3D printing and synthetic resins to create ...
(Date:7/31/2015)... LONDON , July 31, 2015 ... to decades of experience, the domestic pharmaceutical industry is ... today manufacture products to high international standards. ... well known is in sub-Saharan Africa: Morocco has quietly ... after South Africa . Indeed, Moroccan ...
(Date:7/31/2015)... SAN DIEGO , July 31, 2015 ... Eisai Co., Ltd. (Headquarters: Tokyo , ... Halozyme Therapeutics, Inc. (Headquarters: San Diego, California ... , "NASDAQ: HALO") have signed a clinical collaboration agreement ... , "eribulin") in combination with Halozyme,s investigational drug PEGPH20 ...
Breaking Medicine Technology:3D Printing Helps Doctors Rehearse Complex Brain Procedures 23D Printing Helps Doctors Rehearse Complex Brain Procedures 33D Printing Helps Doctors Rehearse Complex Brain Procedures 4PharmaBoardroom Releases New Morocco Pharmaceuticals Report 2PharmaBoardroom Releases New Morocco Pharmaceuticals Report 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 2Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 3Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 4Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 5Eisai and Halozyme Sign Collaboration Agreement to Investigate Eribulin and PEGPH20 in Metastatic Breast Cancer 6
... Young Innovations, Inc. (NASDAQ: YDNT ) today announced ... 2012.  Sales for the first quarter of 2012 ... in the first quarter of 2011. Income from operations increased 5.3% ... million in the first quarter of 2011. Net income increased 5.6% ...
... April 23, 2012  This week COPAN launched videos ... The new videos were created for the Centers ... to be used in a web based course ... for healthcare providers.  The educational videos show proper ...
Cached Medicine Technology:Young Innovations, Inc. Announces Record Sales and EPS for the Quarter Ended March 31, 2012 2Young Innovations, Inc. Announces Record Sales and EPS for the Quarter Ended March 31, 2012 3Young Innovations, Inc. Announces Record Sales and EPS for the Quarter Ended March 31, 2012 4COPAN Produces CDC/Joint Commission Educational Specimen Collection Videos 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: