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Chronic inflammation linked to 'high-grade' prostate cancer
Date:4/17/2014

evious studies began by sampling tissue from men who had some cause to undergo a biopsy, Platz explained. "Our study was designed to rule out the bias that would ordinarily exist between the way we detect prostate cancer and the presence of inflammation."

"Because inflammation makes PSA levels go up, men with inflammation are more likely to have higher PSA and, with a rising PSA, they're more likely to be biopsied," she said. "By doing more biopsies on these men, prostate cancer is more likely to be detected, even if inflammation is not a cause of prostate cancer."

For the study, Platz, De Marzo and colleagues examined benign tissue samples taken from the biopsies of 191 men with prostate cancer and 209 men without cancer, examining the samples for the prevalence and extent of immune cells that indicate inflammation. They found that 86.2 percent of the prostate cancer patients had at least one tissue sample with signs of inflammation, compared to 78.2 percent of men without cancer.

"We knew going into this research that inflammation in the prostate is very common in men who have biopsies because of the higher PSA levels and other indicators of prostate cancer," said De Marzo, who is a professor of pathology at Johns Hopkins' School of Medicine and associate director of cancer research pathology at its Kimmel Cancer Center, "but we did not anticipate the high prevalence of prostate inflammation in men who didn't have an indication for biopsy."

Ultimately, men with at least one tissue sample showing signs of chronic inflammation had 1.78 times higher odds of having prostate cancer, and 2.24 times higher odds of having an aggressive cancer, the researchers concluded. The association held firm even in men with low PSA levels at the time of their biopsies.

The Johns Hopkins team is studying the relationship between PSA levels and detailed measures of inflammation in men with no indications for a prostate biopsy, as well as a p
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Contact: Michelle Potter
mpotter8@jhmi.edu
410-614-2914
Johns Hopkins Medicine
Source:Eurekalert

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