Navigation Links
Chronic high cholesterol diet produces brain damage
Date:11/24/2010

disease.

The aim of the study led by Humpel was to study the effects of hypercholesterolemia in adult rats. Male 6 months old Sprague Dawley rats were fed with normal food (controls) or with a special 5% cholesterol-enriched diet (hypercholesterolemia). After 5 months animals were tested for behavioral impairments and pathological markers similar to those found in the brains of patients with Alzheimer's disease. The results showed that chronic hypercholesterolemia caused memory impairment, cholinergic dysfunction, inflammation, enhanced cortical beta-amyloid and tau and induced microbleedings, all indications, which resemble an Alzheimer's disease-like pathology.

Thus the data are in line with earlier studies showing that high fat lipids, including cholesterol, may participate in the development of sporadic Alzheimer's disease. However, since Alzheimer's disease is a complex heterogenous disease, these data do not allow the conclusion that cholesterol alone is responsible for the disease. It can be speculated that chronic mild cerebrovascular damage caused and potentiated by different vascular risk factors (including cholesterol) may contribute to these pathologies. It needs to be determined in future studies how mild chronic microvascular bleedings, silent strokes and mild blood-brain barrier damage over decades may play a role in the development of this disease. Indeed several data (Ladecola, Nat.Rev.Neurosci. 5, 347-360, 2004) support the view that Alzheimer's disease can be considered as a vascular disease and that a dysfunctional clearance of beta-amyloid from brain to blood and vice versa may be a secondary important step in the cascade of initiation of the disease.


'/>"/>

Contact: Christian Humpel
christian.humpel@i-med.ac.at
43-512-504-23712
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Young patients with chronic illnesses find relief in acupuncture
2. Exposure to 9/11 Fumes Tied to Chronic Headaches
3. One in Two Children Has Chronic Health Issues
4. Chronic Migraines Take a Greater Toll
5. Chronic Fatigue Syndrome-Virus Link Questioned
6. Study Suggests Low-Consuming Medicare Beneficiaries With Chronic Disease Are More Costly to Program
7. Chronic Back Pain Soothed by Cognitive Behavioral Therapy
8. Virus Unlikely to Cause Chronic Fatigue Syndrome
9. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
10. National Study Reports Staggering Spending Increases Among Seniors With Chronic Conditions Through Original Medicare - Special Needs Plan Program Offers Solution For Those In Texas
11. M. D. Anderson develops tool to measure severity of chronic graft-vs.-host disease symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Miami, FL (PRWEB) July 31, 2014 ... (LMS) which continues to help healthcare agencies to ... help companies and agencies meet their accreditation ... with competency based training. , Healthcare administrators ... a few clicks of the mouse. Courses can ...
(Date:7/31/2014)... FL (PRWEB) July 31, 2014 Zensah®, ... released their innovative compression elbow sleeve , designed ... elbow pain, in two new bright colors for summer. ... pink and blue. Made of innovative proprietary Zensah® fabric, ... wicking and odor-preventing fabric. It features a no-slip cuff ...
(Date:7/31/2014)... 31, 2014 To further educate the ... provide the following safety information regarding leaving children in ... can have deadly consequences. Because a child’s body can ... of adults, leaving children alone in a hot vehicle ... even death. , Statistics of Children Left Alone in ...
(Date:7/31/2014)... 2014 Most mommy blogs are simple ... purpose is to attract all mothers from all walks ... particular group; whether its high fashion or child rearing. ... everything on the Internet was so segmented. “I found ... particular topic and then search Google to get information ...
(Date:7/31/2014)... A chance meeting at last April’s ... country artist/writer-producer Jimmy Robbins to Etymotic Research and ... an innovator in hearing wellness solutions, and maker ... 2012, Etymotic’s Music•PRO® Electronic Earplugs have revolutionized hearing ... and restoring natural hearing when hearing is not ...
Breaking Medicine News(10 mins):Health News:Company Helps Healthcare Agencies to Pass Inspections and Audits 2Health News:Company Helps Healthcare Agencies to Pass Inspections and Audits 3Health News:Compression Elbow Sleeve Provides Relief From Elbow Pain to Golfers and Tennis Players 2Health News:Compression Elbow Sleeve Provides Relief From Elbow Pain to Golfers and Tennis Players 3Health News:The Rothenberg Law Firm LLP Teams Up with Local Philadelphia TV Stations to Promote Awareness of the Dangers of Leaving Children Unattended in a Hot Vehicle 2Health News:The Rothenberg Law Firm LLP Teams Up with Local Philadelphia TV Stations to Promote Awareness of the Dangers of Leaving Children Unattended in a Hot Vehicle 3Health News:Mommylish Launches Its Website 2Health News:Country Star Jimmy Robbins Now Using Etymotic’s MusicPRO Electronic Earplugs 2
... ultrasound and specially modified contrast agents may allow researchers ... to research published in the March issue of The ... The technique enables researchers to visualize tumor activity at ... be helpful for the early detection of disease," said ...
... If the behavior of the seasonal form of the ... are good that most strains of the pandemic H1N1 flu ... for use against it. Researchers at Ohio State University ... virus, which first infected humans during the 1918 pandemic. It ...
... ... beef sold at checkout could help save lives when E. coli outbreaks happen because ... identify the products that are making people sick in order to bring outbreaks under ... ...
... ... has launched an improved web viewer for its flagship Evercore® – Clinical Enterprise Suite ... of the size of the facility. , ... Milwaukee, WI (PRWEB) March 1, 2010 -- TeraMedica Healthcare Technology, ...
... ... in Pharma, Health and Wellness. , ... Philadelphia, PA (PRWEB) March 1, 2010 -- Acknowledging more than 13 ... for specialization, Razorfish has launched Razorfish Health , a dedicated health and wellness ...
... ... ... ... ...
Cached Medicine News:Health News:The proof's in the bubbles 2Health News:Pandemic flu, like seasonal H1N1, shows signs of resisting Tamiflu 2Health News:Pandemic flu, like seasonal H1N1, shows signs of resisting Tamiflu 3Health News:Pandemic flu, like seasonal H1N1, shows signs of resisting Tamiflu 4Health News:Food Safety Attorney Fred Pritzker Calls on Food Retailers to Keep Precise Beef Handling Records 2Health News:Food Safety Attorney Fred Pritzker Calls on Food Retailers to Keep Precise Beef Handling Records 3Health News:TeraMedica Unveils Improved Univision, Now Offering a Multi-Layer Enterprise Viewing Platform 2Health News:Razorfish Launches Independent Dedicated Health Brand 2Health News:Razorfish Launches Independent Dedicated Health Brand 3Health News:Razorfish Launches Independent Dedicated Health Brand 4Health News:California to Examine Health Impacts of Landmark Cap-and-Trade Program 2Health News:California to Examine Health Impacts of Landmark Cap-and-Trade Program 3Health News:California to Examine Health Impacts of Landmark Cap-and-Trade Program 4Health News:California to Examine Health Impacts of Landmark Cap-and-Trade Program 5
(Date:7/31/2014)... and VIENNA , July 31, ... a press conference in New York ... a vaccine against Parkinson,s disease. PD01A is the first therapy ... enter clinical testing. The Michael J. Fox Foundation ... 1.5 million grant, and presented at the press conference on ...
(Date:7/31/2014)... and LONDON , July 31, 2014 /PRNewswire/ ... services provider for the medical industries, announced today the incorporation of ... United Kingdom has one of the largest ... 8.9 billion in 2012 and it is projected to increase by ... USD 234 billion in 2012, equal to 9.5% of GDP. Despite ...
(Date:7/31/2014)... Texas , July 31, 2014 Vermillion, Inc. ... and women,s health, will hold a conference call on Thursday, ... results for the second quarter ended June 30, 2014. Financial ... the call. Vermillion,s Chairman, President and CEO ... question and answer period. Date: Thursday, August 14, ...
Breaking Medicine Technology:First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 2First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 3First Clinical Data of Therapeutic Parkinson's Disease Vaccine Encourages Continued Development 4genae Opens Offices in London 2Vermillion Sets Second Quarter 2014 Conference Call for Thursday, August 14, 2014 2
... HOFFMAN ESTATES, Ill., Jan. 24, 2012 Life Spine, a ... for the surgical treatment of spinal disorders, announced record revenues ... introductions in 2011. The record revenue reflects ... 2011. "This has been an outstanding year for Life Spine. ...
... 2012  LoneStar Heart Inc., based here, today announced that ... Maciejewski to the company,s board of directors. The new ... for LoneStar Heart; Frank Ahmann, the company,s president and ... of Vessix Vascular, Inc.; and Eric N. Olson, Ph.D., ...
Cached Medicine Technology:LoneStar Heart Inc. Names Andrew J. Coats, M.D., and Mark Maciejewski to Its Board of Directors 2LoneStar Heart Inc. Names Andrew J. Coats, M.D., and Mark Maciejewski to Its Board of Directors 3
... of German Craftsmanship have ... instrumentation in the world. ... available to you! Only ... Meisterbrief certificate, which requires ...
... are constructed of a patented ... polyvinyl acetal sponge. Each device ... to both surgeon and patient, ... firm enough to gently manipulate ...
... Products provide the surgeon ... products for unparalleled fluid ... of fine microsurgical instruments. ... is highly absorbent, fast ...
... KeraCel Ophthalmic Products are ... formulation of lint-free MEROCEL polyvinyl ... configured to be beneficial to ... being absorbent, and yet firm ...
Medicine Products: