Navigation Links
Chronic high cholesterol diet produces brain damage
Date:11/24/2010

London, UK, 24 November 2010 Research from the Laboratory of Psychiatry and Experimental Alzheimers Research (http://www2.i-med.ac.at/psychlab/) at the Medical University Innsbruck (Austria) demonstrated that chronic high fat cholesterol diet in rats exhibited pathologies similar to Alzheimer's disease. The results were published in Molecular Cellular Neuroscience (45(4):408-417, 2010) with lead author Dr. Christian Humpel. The study was co-authored by PhD students, Celine Ullrich and Michael Pirchl, from the same Laboratory.

Alzheimer's disease is a severe neurodegenerative disorder of the brain that is characterized by loss of memory and cognitive decline. The majority of Alzheimer's disease cases are sporadic (risk age >60 years), and only <2.5% have a genetic disposition. It is estimated that in 2050, approximately 80 million people will suffer from Alzheimer's disease worldwide. The major pathological hallmarks of Alzheimer's disease are extracellular aggregates (plaques) of the small peptide beta-amyloid, hyperphosphorylation of the protein tau and subsequent formation of intracellular neurofibrillary tangles, degeneration of neurons secreting the neurotransmitter acetylcholine, inflammation, and cerebrovascular dysfunction.

The causes for Alzheimer's disease are not known, but dysregulation of amyloid-precursor protein expression and beta-amyloid clearance is hypothesized (beta-amyloid cascade). Alternatively, a pathological cascade of events may trigger hyper-phosphorylation of tau, putting the tau-hypothesis into the center. A third hypothesis suggests that chronic long-lasting mild cerebrovascular damage, including inflammatory processes and oxidative stress, may cause Alzheimer's disease. It has been suggested that Alzheimer's disease starts 20-30 years before first symptoms appear and recent studies have shown, that high cholesterol levels are linked to the pathology of this
'/>"/>

Contact: Christian Humpel
christian.humpel@i-med.ac.at
43-512-504-23712
Elsevier
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Young patients with chronic illnesses find relief in acupuncture
2. Exposure to 9/11 Fumes Tied to Chronic Headaches
3. One in Two Children Has Chronic Health Issues
4. Chronic Migraines Take a Greater Toll
5. Chronic Fatigue Syndrome-Virus Link Questioned
6. Study Suggests Low-Consuming Medicare Beneficiaries With Chronic Disease Are More Costly to Program
7. Chronic Back Pain Soothed by Cognitive Behavioral Therapy
8. Virus Unlikely to Cause Chronic Fatigue Syndrome
9. New Study: Improved Immune System with Gene-Eden, a Natural Antiviral Supplement that Targets Chronic Viruses
10. National Study Reports Staggering Spending Increases Among Seniors With Chronic Conditions Through Original Medicare - Special Needs Plan Program Offers Solution For Those In Texas
11. M. D. Anderson develops tool to measure severity of chronic graft-vs.-host disease symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... West Palm Beach, Florida (PRWEB) September 30, 2014 ... of Florida make the treatment of gum disease ... traditional treatments of the past. , “If you’ve ever felt ... into ice cream or sip a cold beverage, it’s possible ... Herbert Salisbury , who is a general dentist in ...
(Date:9/30/2014)... (HealthDay News) -- Medicare should cover low-dose computed tomography ... the disease, a coalition of more than 60 patient ... the Lung Cancer Alliance, the Society of Thoracic Surgeons, ... and the American Society of Clinical Oncology, made its ... Centers for Medicare & Medicaid Services (CMS). Such ...
(Date:9/30/2014)... made progress in reducing the stigma associated with seeking ... stress disorder, but more improvement is still needed, according ... of both the Defense Department and the Veterans Health ... still do not seek needed care for mental ... to promote treatment as a way to reduce stigma, ...
(Date:9/30/2014)... a gene mutation that causes a rare premature aging ... block the rapid, unstoppable cell division that makes cancer ... Michigan and the U-M Health System recently discovered a ... in which precious hematopoietic stem cells can,t regenerate and ... are prone to cancer and bone marrow failure. ...
(Date:9/30/2014)... FDA-approved injectable dermal fillers (i.e. hyaluronic ... in several procedures that are performed to restore ... primarily used for wrinkle treatment of the skin, ... are being used as popular treatments in nonsurgical ... the hands. (1) (2) Dr. Cynthia Elliott of ...
Breaking Medicine News(10 mins):Health News:Florida Dentist Battles Gum Disease With Latest Techniques 2Health News:Florida Dentist Battles Gum Disease With Latest Techniques 3Health News:Groups Call for Medicare Coverage of Lung Cancer Screening 2Health News:US military making progress reducing stigma tied to seeking help for mental illness 2Health News:US military making progress reducing stigma tied to seeking help for mental illness 3Health News:Disease decoded: Gene mutation may lead to development of new cancer drugs 2Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 2Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 3Health News:Nonsurgical Cosmetic How-To: Skinspirations Details Proper Use of FDA-Approved Injectable Fillers for Hand Rejuvenation Procedures 4
... Hopkins Kimmel Cancer Center researchers say preliminary studies show ... able to reduce or eliminate the last remaining cancer ... the drug Imatinib mesylate (Gleevec). Gleevec, one of ... CML patients, destroys most leukemic cells in the body, ...
... new study, scientists have searched for mutations in the gene regions ... samples from a single tumour type to be sequenced to date. ... type of kidney cancer, with 102,000 deaths worldwide each year. It ... its nature is remarkably consistent and the majority of cases ...
... arthritis (RA) patients are partially protected by the influenza ... determined that while the flu vaccine is safe, it ... months following rituximab treatment. Previous influenza vaccination in ... some defense to influenza strains. RA activity was ...
... /CNW/ - A recent evaluation by the Centre for Addiction ... alcohol use can be effective in changing drinking behaviours and ... first evaluation of its kind, the study published in ... online screener www.CheckYourDrinking.net, reduced their alcohol consumption by 30% - ...
... of mental health professionals, emergency response experts, and researchers ... results of a study that shows serious emotional disturbances ... Category 3 storm ravaged the Gulf Coast in August ... of the Journal of the American Academy of ...
... the US population becomes increasingly obese while smoking rates continue ... contributor to the burden of disease and shortening of healthy ... the February 2010 issue of the American Journal of ... College of New York calculate that the Quality-Adjusted Life Years ...
Cached Medicine News:Health News:Johns Hopkins researchers say vaccine appears to 'mop up' leukemia cells Gleevec leaves behind 2Health News:Unraveling kidney cancer 2Health News:Unraveling kidney cancer 3Health News:Efficacy of flu vaccine drastically reduced for RA patients treated with rituximab 2Health News:Technology new gateway into treatment for problem alcohol users: Study 2Health News:Obesity now poses as great a threat to quality of life as smoking 2
(Date:9/30/2014)... , Sept. 30, 2014 Passport Health, one ... , has launched FluFree.com, a website designed to ... For 20 years, Passport Health has provided ... flu. The launch of FluFree.com is designed to address ... the number of people who actually chose to get ...
(Date:9/30/2014)... September 2014 ... Acutus Medical, Inc. ... 3D-Herzkammer-Bildgebungs- und Dipoldichte-Mappingsystem in Echtzeit zur ... komplexen Herzrhythmusstörungen einschließlich Vorhofflimmern führen bzw. ... zusätzlichen Finanzierung über 26,2 Mio. USD ...
(Date:9/30/2014)... , Sept. 30, 2014  Arena Solutions, the ... today announced its Fall 2014 release, which includes ... and Arena DataExtract – and significant ... available products are focused specifically on speeding time ... aggregation of a complete history of tribal knowledge ...
Breaking Medicine Technology:Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 2Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 3Acutus Medical, Inc. schließt zusätzliche Finanzierungsrunde Serie B über 26,2 Mio. USD ab, um Portfolio-Erweiterung zu finanzieren 2Acutus Medical, Inc. schließt zusätzliche Finanzierungsrunde Serie B über 26,2 Mio. USD ab, um Portfolio-Erweiterung zu finanzieren 3Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 2Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 3Arena Unveils Unique PLM Collaboration Platform And New Data Extraction Tool 4
... oxygen flowmeters., ,Options: , ... S to model number. Example: ... add suffix C to model ... Double Flowmeters with Power Take-Off, ...
... flowmeters., ,Options: , For ... to model number. Example: FMC107S. ... suffix C to model number. ... Flowmeters with Power Take-Off, add ...
... Slim Line Flowmeters with brass and ... security chain, add suffix S to ... Canadian Color-Code, add suffix C to ... Double Flowmeters with Power Take-Off, add ...
... Flowmeters with brass and aluminum body., ... add suffix S to model number. ... add suffix C to model number. ... with Power Take-Off, add PT to ...
Medicine Products: