Navigation Links
Chronic exposure to staph bacteria may be risk factor for lupus, Mayo study finds
Date:8/8/2012

ROCHESTER, Minn. -- Chronic exposure to even small amounts of staph bacteria could be a risk factor for the chronic inflammatory disease lupus, Mayo Clinic research shows. Staph, short for Staphylococcus aureus, is a germ commonly found on the skin or in the nose, sometimes causing infections. In the Mayo study, mice were exposed to low doses of a protein found in staph and developed a lupus-like disease, with kidney disease and autoantibodies like those found in the blood of lupus patients.

The findings are published online this month in The Journal of Immunology. The next step is to study lupus patients to see if the staph protein in question plays a similar role in humans, says co-author Vaidehi Chowdhary, M.D., a Mayo Clinic rheumatologist.

"We think this protein could be an important clue to what may cause or exacerbate lupus in certain genetically predisposed patients," Dr. Chowdhary says. "Our hope is to confirm these findings in lupus patients and hopefully prevent flares."

Another key question is whether treating at-risk people to eradicate staph can prevent lupus from forming in the first place. Lupus occurs when the immune system attacks tissues and joints. It may affect virtually any part of the body and can be tough to diagnose because it often mimics other ailments. There is no cure, only treatment to control symptoms. Lupus is more commonly diagnosed in women, African-Americans, Hispanics, Asians and people 15 to 40.

The cause is often unknown; it appears people genetically predisposed to lupus may develop it when something in the environment triggers it, such as infections, certain drugs or even sunlight.

Physicians do not really know what causes lupus, so the discovery of the staph protein's possible role is exciting, Dr. Chowdhary says.

In the mice studied, a staph protein known as a staphylococcal enterotoxin B, or SEB, activated autoreactive T and B lymphocytes, a type of white blood cells, leading to an inflammatory illness mirroring lupus. Research on people has shown that carrying staph bacteria is linked to autoimmune diseases such as psoriasis, Kawasaki disease and graulomatosis with polyangiitis.


'/>"/>

Contact: Sharon Theimer
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Chronic Butter Flavoring Exposure Linked to Harmful Brain Process
2. Common Skin Cancer a Chronic Condition, Study Says
3. Chronic vulvar pain related to irritable bowel syndrome, fibromyalgia and interstitial cystitis
4. Study finds people have difficulty controlling multiple chronic conditions
5. More Americans Have at Least 2 Chronic Health Issues: CDC
6. Asthma is the most common chronic disease among Olympic athletes
7. A nursing program shows promise for reducing deaths from chronic illnesses
8. U-M researchers identify new genetic cause for chronic kidney disease
9. Childhood adversity increases risk for depression and chronic inflammation
10. Chronic Pain May Depend on Emotional Reaction to Injury
11. Analysis of KRYSTEXXA phase III data demonstrates improved health-related quality of life and physical function in refractory chronic gout patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/20/2020)... ... February 20, 2020 , ... R3 Stem Cell, the nation's leader in regenerative ... complimentary stem cell procedures on military veterans in 2019. The veterans traveled ... At the R3 Stem Cell Training Course for doctors , providers of all kinds ...
(Date:2/19/2020)... (PRWEB) , ... February 19, 2020 , ... ... at Advanced Periodontics and Dental Implant Center of Connecticut, celebrate 30 years of ... patients with the same low fees that they charged in 1989, only thirty ...
(Date:2/19/2020)... ... , ... In 2017, the EU’s revamped Medical Device Regulation ... govern medical device manufacturers under the Medical Devices Directive (MDD); the timeline provided ... from the previous MDD include:, , Elimination of the ...
(Date:2/19/2020)... Ga. (PRWEB) , ... February 19, 2020 , ... ... announce they are holding a CoolEvent for FDA-cleared CoolSculpting®, the world’s most popular ... 6345 Halcyon Way, Suite 850 in the Halcyon Village Center in Alpharetta, Georgia. ...
(Date:2/15/2020)... ... February 14, 2020 , ... Sister companies, Special Learning ... “BIG MONEY IN ABA”. The series explores the challenges, risks, and opportunities of ... the series on March 25, 2020 at: https://bit.ly/2OU6lxg , Since 2010, ...
Breaking Medicine News(10 mins):
(Date:2/15/2020)... Fla. (PRWEB) , ... February 14, 2020 , ... ... has established an "oral-systemic” link between the organisms that cause inflammatory gum disease ... from Tampa-based ProBiora Health?? , offers new tools in the fight against ...
(Date:2/14/2020)... ... February 14, 2020 , ... Dignitana AB , world leader in scalp ... on to sponsor three signature events in 2020 with Susan G. Komen®. The sponsorship ... Race for the Cure® and MORE THAN PINK Walk® events in key Dignitana markets ...
(Date:2/14/2020)... ... February 14, 2020 , ... The ... Children’s Healthcare of Atlanta (Children’s) raised through their annual Holiday Giving Campaign. The ... new or pre-owned vehicle sales between November 29, 2019, through January 2, 2020, ...
Breaking Medicine Technology: