Navigation Links
Chronic diarrhea unresponsive to conventional medication: Are you taking lansoprazole?
Date:5/13/2009

Lansoprazole is a proton pump inhibitor which powerfully suppresses gastric acid production and is widely prescribed for chronic use in gastroesophageal reflux disease. Lansoprazole uncommonly causes chronic watery diarrhea unresponsive to conventional medication as a symptom of collagenous colitis. This association has recently been reported and is not widely known. Correct diagnosis and treatment without this knowledge is impossible. Discontinuation of lansoprazole results in the prompt resolution of diarrhea.

A 70-year old woman developed watery diarrhea 4 to 9 times a day. She had interstitial pneumonia at 67 and reflux esophagitis at 70. Lansoprazole 30 mg/day had been prescribed for reflux esophagitis for nearly 6 months. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/day was started. The patient's diarrhea dramatically disappeared the following day. However, biopsy specimens showed subepithelial collagenous thickening and infiltration of inflammatory cells in the lamina propria confirming the diagnosis of collagenous colitis. One month after sulfasalazine therapy was initiated, both colonoscopic and histological abnormalities resolved completely. Five months later the diarrhea recurred. The findings on colonoscopy and histology were the same as before confirming a diagnosis of collagenous colitis relapse. The author found that the patient had been taking lansoprazole again three months ahead of the recent episode of diarrhea. Withdrawal of lansoprazole promptly resolved the diarrhea. Endoscopic and histological abnormalities were also completely resolved similar to the first episode. Retrospectively, the date of commencement of sulfasalazine and the discontinuation of lansoprazole in the first episode was found to be the same. The author concluded that the patient had lansoprazole-associated collagenous colitis.

This case is reported by Dr. Chiba and his colleagues in the Division of Gastroenterology, Nakadori General Hospital, Akita, Japan and it is to be published on May 7, 2009 in the World Journal of Gastroenterology.

A doctor and a patient can easily recognize the side effects of medication taken recently. However, symptoms occurring in chronic use of a drug such as the present case, diarrhea 6 months after taking lansoprazole, it might be difficult to suspect this side effect. Therefore, knowledge is important: lansoprazole in chronic use can cause chronic diarrhea as a symptom of collagenous colitis.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Avalere Shows Home Health Interventions Associated with Lower Medicare Spending and Re-Hospitalizations for Patients With Chronic Illness
2. Bipartisan Coalition Forms to Call for Chronic Disease to be Key Focus of Health Reform in Indiana and Nationally
3. The Center for the Biology of Chronic Disease Highlights Anti-Cancer Activities of the Food Extracts Quercetin, EGCG, Glycyrrhizin, and Trans-Cinnamaldehyde
4. Chronic Kidney Disease Raises Risk for Some Cancers
5. Chronic ankle pain may be more than just a sprain
6. New Hope for Relief of Chronic Sciatica
7. Report Finds an Alarming Number of Chronically Ill Patients - Over 93 Percent - Reporting Medical Debt Crisis Issues in 2008 Have Some Form of Insurance
8. Award-winning partnership proves Vocantas CallAssure effective tool for chronic disease management
9. A New, Highly Effective, Non-Narcotic Pain Medication Now Available for Chronic Pain Patients
10. Different treatment options in chronic coronary artery disease
11. First evidence for DNA-based vaccination against chronic hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... February 26, 2017 , ... Miro is the ultimate smart media ... system brings songs, movies, TV shows and much more apps for user exploration. Its ... An immersive view of 1280 x 720 provides crisp images with remarkable clarity and ...
(Date:2/27/2017)... ... February 27, 2017 , ... ... mark last week. In addition, Discount Power's RCE (Residential Customer Equivalent) count exceeds ... March 2014. The company had 800 customers and 2,250 RCEs at the time ...
(Date:2/27/2017)... (PRWEB) , ... February 27, 2017 , ... ... hair transplantation therapy, is proud to announce a new informational post on robotic ... procedures. Follicular Unit Extraction (FUE) hair transplant and Follicular Unit Transplantation (FUT) can ...
(Date:2/27/2017)... ... 27, 2017 , ... New Jersey ranks among the top five states in ... the need for advanced services is growing. , Project WE vs C is ... collaboration with their non-profit partners in their fight against cancer and in support of ...
(Date:2/26/2017)... ... February 26, 2017 , ... Today, A' Design ... Edition of International Social Design Awards. , The 7th A' Social Design ... Governments and Institutions worldwide with realized projects and conceptual works. , The first ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... , Feb. 27, 2017  CTI BioPharma Corp. (CTI BioPharma) ... Adam Craig , M.D., Ph.D., as President and Chief Executive ... March 20, 2017. Dr. Craig succeeds Richard Love , ... the company,s Board of Directors.  Dr. Craig has over 20 ... both the US and Europe . ...
(Date:2/24/2017)... -- Following receiving CE ... , s AMAR is a major milestone for the country ... w ound care market in Israel ... BST for inclusion in the National Health Basket , ...   E-QURE Corp. (OTCQB: EQUR), a leader in medical devices for ...
(Date:2/24/2017)... and Markets has announced the addition of the "Dry eye Drugs ... ... Drugs Price Analysis and Strategies - 2016, provides drug pricing data and ... following questions: What are the key drugs ... in the Global Dry eye market? What are the ...
Breaking Medicine Technology: