Navigation Links
Chronic diarrhea unresponsive to conventional medication: Are you taking lansoprazole?
Date:5/13/2009

Lansoprazole is a proton pump inhibitor which powerfully suppresses gastric acid production and is widely prescribed for chronic use in gastroesophageal reflux disease. Lansoprazole uncommonly causes chronic watery diarrhea unresponsive to conventional medication as a symptom of collagenous colitis. This association has recently been reported and is not widely known. Correct diagnosis and treatment without this knowledge is impossible. Discontinuation of lansoprazole results in the prompt resolution of diarrhea.

A 70-year old woman developed watery diarrhea 4 to 9 times a day. She had interstitial pneumonia at 67 and reflux esophagitis at 70. Lansoprazole 30 mg/day had been prescribed for reflux esophagitis for nearly 6 months. Lansoprazole was withdrawn due to its possible side effect of diarrhea. Colonoscopy disclosed diffuse cloudiness of the mucosa which suggested ulcerative colitis. Consequently sulfasalazine 2 g/day was started. The patient's diarrhea dramatically disappeared the following day. However, biopsy specimens showed subepithelial collagenous thickening and infiltration of inflammatory cells in the lamina propria confirming the diagnosis of collagenous colitis. One month after sulfasalazine therapy was initiated, both colonoscopic and histological abnormalities resolved completely. Five months later the diarrhea recurred. The findings on colonoscopy and histology were the same as before confirming a diagnosis of collagenous colitis relapse. The author found that the patient had been taking lansoprazole again three months ahead of the recent episode of diarrhea. Withdrawal of lansoprazole promptly resolved the diarrhea. Endoscopic and histological abnormalities were also completely resolved similar to the first episode. Retrospectively, the date of commencement of sulfasalazine and the discontinuation of lansoprazole in the first episode was found to be the same. The author concluded that the patient had lansoprazole-associated collagenous colitis.

This case is reported by Dr. Chiba and his colleagues in the Division of Gastroenterology, Nakadori General Hospital, Akita, Japan and it is to be published on May 7, 2009 in the World Journal of Gastroenterology.

A doctor and a patient can easily recognize the side effects of medication taken recently. However, symptoms occurring in chronic use of a drug such as the present case, diarrhea 6 months after taking lansoprazole, it might be difficult to suspect this side effect. Therefore, knowledge is important: lansoprazole in chronic use can cause chronic diarrhea as a symptom of collagenous colitis.


'/>"/>

Contact: Lin Tian
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Avalere Shows Home Health Interventions Associated with Lower Medicare Spending and Re-Hospitalizations for Patients With Chronic Illness
2. Bipartisan Coalition Forms to Call for Chronic Disease to be Key Focus of Health Reform in Indiana and Nationally
3. The Center for the Biology of Chronic Disease Highlights Anti-Cancer Activities of the Food Extracts Quercetin, EGCG, Glycyrrhizin, and Trans-Cinnamaldehyde
4. Chronic Kidney Disease Raises Risk for Some Cancers
5. Chronic ankle pain may be more than just a sprain
6. New Hope for Relief of Chronic Sciatica
7. Report Finds an Alarming Number of Chronically Ill Patients - Over 93 Percent - Reporting Medical Debt Crisis Issues in 2008 Have Some Form of Insurance
8. Award-winning partnership proves Vocantas CallAssure effective tool for chronic disease management
9. A New, Highly Effective, Non-Narcotic Pain Medication Now Available for Chronic Pain Patients
10. Different treatment options in chronic coronary artery disease
11. First evidence for DNA-based vaccination against chronic hepatitis C
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... "FCPX LUT ... quality of your footage," said Christina Austin - CEO of Pixel Film Studios. ... can quickly and easily add stylish color grades to their footage. A LUT is ...
(Date:5/25/2016)... ... May 25, 2016 , ... HealthPostures ... will join America's leading engineers at the American Society of Safety Engineers Conference ... Congress Center. , Engineers, speakers and exhibitors from more than 40 countries ...
(Date:5/24/2016)... ... May 24, 2016 , ... BTC Media, a ... event, Distributed: Health, to be held in Nashville, Tennessee on September 7, 2016. ... 24-hour Hackathon preceding the event will host teams from around the world, competing ...
(Date:5/24/2016)... , ... May 24, 2016 , ... ... a new corporate identity and website at its “Transforming Outcomes” User Conference in ... marketing enhancements reflect i2i’s ongoing success to set the market standard for meaningful ...
(Date:5/24/2016)... VA (PRWEB) , ... May 24, 2016 , ... ... for the Surgery Center at Sentara Northern Virginia Medical Center located in Woodbridge, ... of the hospital’s surgical services into a single site. , The new 2 ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... May 24, 2016 The ... world , s first dual therapy stent, ...   OrbusNeich, a global company specializing in ... portfolio to include products to treat peripheral artery disease. ... first entry devices for lower limb and arteriovenous (AV) ...
(Date:5/24/2016)... 2016 Dutch surgeons have launched a ground-breaking ... world and treat patients on a global scale. Medical professionals from ... Asia and the US have already signed up ... networking in a totally secure environment. Education  ... working together with a surgeon at Harvard to treat a bomb ...
(Date:5/23/2016)... Mich. , May 23, 2016 Diplomat Pharmacy, ... third annual Fellowship and Internship programs. The hands-on learning ... The full-time, paid Fellowship and ... Flint, Michigan . Fellows and interns are provided ... Flint at the Riverfront Residence ...
Breaking Medicine Technology: