Navigation Links
Chronic Kidney Disease Raises Risk for Some Cancers
Date:5/1/2009

Study found increased chances of urinary/lung malignancies among older men

FRIDAY, May 1 (HealthDay News) -- Older men who suffer from moderate chronic kidney disease appear to have a higher risk for developing certain kinds of cancers, a team of Australian scientists report.

The observation -- which suggests a bump in the risk for lung and/or urinary cancer, but not prostate cancer -- adds to previous evidence that patients with end-stage renal disease and those undergoing kidney transplantation are at an increased risk for developing a malignancy.

Results of the research effort, led by Dr. Germaine Wong from the Center for Transplant and Renal Research at Children's Hospital in Westmead, Australia, are being published in the April 30 online issue of the Journal of the American Society Nephrology.

According to the National Kidney Foundation, 26 million Americans currently suffer from chronic kidney disease, and seniors -- along with blacks, Hispanics, Native Americans, and Pacific Islanders -- face a particularly high risk for developing the illness.

In the new study, Wong and her colleagues analyzed a decade's worth of data on more than 3,600 Australian men who were between the ages of 49 and 97 and predominantly white.

Noting that nearly 20 percent of the men went on to develop cancer during the study period, the research team found that moderate kidney dysfunction was, in fact, associated with a 39 percent increased risk for certain cancers.

They further noted that men with "significant" kidney disease faced three times the risk for developing cancer, as compared with those men who retained normal kidney function.

While highlighting the need for more research, the Australian team theorize that kidney disease and cancer could be linked via the systemic inflammation that results from chronic kidney disease.

Dr. Matthew Weir, director of the division of nephrology at the University of Maryland School of Medicine in Baltimore, described the findings as "important new information."

"We've known for many years that people with end-stage kidney disease have an increased risk for malignancy in general, and renal cancer in particular," he noted. "And this study provides a logical extension of this previous observation, in that we now see that there is a graded relationship of risk for cancer, and that once again renal disease is the top of the list."

"So people with chronic kidney disease need cancer screening," Weir added, "and we need to pay attention to how we monitor them for this risk. And it is also important that patients who are referred for organ transplantation, which is one of the best options for people with chronic kidney disease, are carefully worked up regarding immunosuppression, so that we're not transplanting people with [hidden] malignancies."

Dr. Robert Provenzano, chief of nephrology at St. John Hospital and Medical Center in Detroit and vice-president of medical affairs for DaVita, the country's largest dialysis provider, agreed that the current finding makes sense given the information researchers already have regarding kidney disease.

"Over the last five years we've come to know that right out of the box all patients with chronic kidney disease of any severity have a much higher mortality rate then those who don't," he noted. "So, this finding about a link between moderate kidney disease and cancer doesn't surprise me, because the notion that one can have 'mild' kidney disease is a misnomer to begin with. It's like saying you have mild AIDS. If you have kidney disease of any severity at any age then your inflammatory response is triggered by definition, period. And this leads to all sorts of bad things, such as inflaming the lining of your blood vessels, which can lead to a heart attack, or negatively impacting your ability to kill cancer cells."

"And the probability of getting both chronic kidney disease or cancer simply goes up with age," Provenzano said. "It's just a fact. So the message here is that even for so-called mild chronic kidney disease, doctors and patients need to be vigilant about being monitored for these concerns."

More information

For additional information and resources on chronic kidney disease, visit the National Kidney Foundation.



SOURCES: Robert Provenzano, M.D., chief, nephrology, St. John Hospital and Medical Center, Detroit, and vice president, medical affairs, DaVita, Los Angeles; Matthew Weir, M.D., professor, medicine, and director, division of nephrology, University of Maryland School of Medicine, Baltimore; April 30, 2009, Journal of the American Society Nephrology, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New research shows how chronic stress worsens neurodegenerative disease course
2. Katie Lee Joel to Conduct Cooking Demonstration for Local Patients With Chronic Kidney Disease
3. Study identifies key player in the bodys immune response to chronic stress
4. Preparation for Natural Disasters Critical for People With Diabetes, Chronic Medical Conditions
5. Patient Advocate Foundation Launches Program to Help Uninsured Virginians with Chronic, Debilitating and Life-Threatening Illness Access Quality Healthcare
6. The Leukemia & Lymphoma Society Hosts Workshop On Weighing Treatment Options For Chronic Myelogenous Leukemia
7. Link Between Chronic Pain and Insomnia Uncovered at PAINWeek 2007
8. Methadone and systematic follow-up: the best solution for managing chronic pain
9. NASN Joins Partnership to Fight Chronic Disease
10. Stomach Virus a Culprit in Chronic Fatigue Syndrome
11. Chronic fatigue syndrome linked to stomach virus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chronic Kidney Disease Raises Risk for Some Cancers
(Date:4/22/2017)... , ... April 22, 2017 ... ... of Eastern Pennsylvania has named PROSHRED® Security of Philadelphia its “Woman-Owned ... PROSHRED® Philadelphia specializes in providing information destruction , recycling, and ...
(Date:4/21/2017)... ... April 21, 2017 , ... An April 10 article ... of ancient teeth, which reveal a great deal about prehistoric ice-age dental practitioners and ... may have been used to remove decayed dental matter, and that teeth were then ...
(Date:4/21/2017)... ... April 21, 2017 , ... Chicago plastic surgeon, Dr. Anil R. Shah, ... is a benign bony lump located on the forehead usually attributed to a facial ... sight and pain. Dr. Shah has discovered an approach that is minimally invasive. He ...
(Date:4/21/2017)... ... 2017 , ... Dudnyk has announced the launch of its new brand identity, ... potential of specialty and orphan brands can only be achieved when the needs and ... Effect is at the heart of a true partnership between our agency and our ...
(Date:4/21/2017)... Hong Kong (PRWEB) , ... April 21, 2017 , ... ... Printing (U3DP), the first 3D printing facility among higher education institutions in Hong Kong ... 3D printing, in terms of the range and quantity of facilities in Hong Kong. ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 19, 2017  Sorrento Therapeutics, Inc. (NASDAQ: ... company developing new treatments for cancer and other ... its previously announced underwritten public offering of 23,625,084 ... offering price of $2.00 per share, before deducting ... payable by Sorrento.  The net proceeds to Sorrento ...
(Date:4/19/2017)... HANOVER, N.J. , April 19, 2017 /PRNewswire/ ... conducted by the National Heart, Lung, and Blood ... (NIH) demonstrating that 58% of patients with treatment-naïve ... six months when treated with eltrombopag at the ... 1 . The study evaluated three sequential treatment ...
(Date:4/18/2017)... MINNEAPOLIS , April 18, 2017 Cogentix ... focused on providing the Urology, Uro/Gyn and Gynecology markets ... for the first quarter ended March 31, 2017 after ... The Company will host a conference call ... day on Tuesday, May 2, 2017 at 4:30 p.m. ...
Breaking Medicine Technology: