Navigation Links
Chronic Exposure to Solvents Disturbs Brain's Wiring
Date:4/18/2008

Changes in dopamine receptor density affects memory and psychomotor speed, study says

FRIDAY, April 18 (HealthDay News) -- Long-term exposure to solvents in products such as paints and dry cleaning agents may cause disturbances in the brain's wiring, researchers report.

These abnormalities play a role in a condition called chronic solvent-induced encephalopathy (CSE), the Dutch team conclude in the April issue of the Annals of Neurology.

People with CSE experience problems with memory, attention and psychomotor function long after exposure to solvents has ceased, according to background information in the study. Cases of CSE, a recognized occupational health problem, are increasing in a number of western nations.

This study found that disturbances within the brain's frontal-striatal-thalamic (FST) circuitry are related to the clinical characteristics of CSE, as well as to the severity of exposure to solvents.

The study included 10 CSE patients who'd been exposed to solvents and had mild to severe cognitive impairment, 10 people who'd been exposed to solvents but had no CSE symptoms, and 11 people with no exposure to solvents and no CSE symptoms.

All the participants underwent a number of tests, including MRI and single photon emission computed tomography (SPECT) scans to assess their FST circuitry.

The CSE patients had reduced striatal dopamine D2 receptor (D2R) binding ratios, which were predictive of impaired psychomotor speed and attention, and were also linked to solvent exposure severity, the study authors found. Dopamine receptor density is believed to play a role in psychomotor speed.

The 10 people who were exposed to solvents but had no CSE symptoms showed similar reductions but to a lesser extent. Both groups showed reduced levels of choline (which plays a role in neurotransmission) in the frontal grey matter of the brain.

The results indicate that certain parts of the FST circuitry are affected in CSE patients and in workers who've been exposed to solvents but don't have any CSE symptoms, the study authors said.

"A better understanding of the nature, severity and specificity of these suspected biological markers may further validate diagnostic procedures, this reinforcing medical and social recognition, and underlining the importance of prevention," wrote Ieke Visser, of the Academic Medical Center in Amsterdam, and colleagues.

More information

The U.S. National Library of Medicine has more about CSE.



-- Robert Preidt



SOURCE: Annals of Neurology, news release, April 15, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Overuse of Opioids, Barbiturates Boosts Chronic Migraine Risk
2. New Jersey Leaders Join Forces to Battle Chronic Disease
3. Disturbances in brain circuitry linked to chronic exposure to solvents
4. Potential blood test for chronic sinusitis identified
5. Studies Confirm Balloon Sinuplasty(TM) Helps Chronic Sinusitis Patients
6. Disease Management Programs that Focus on Needs of Chronically Ill Patients Can Provide Positive, Cost-Effective Results
7. Chronically Ill Patients Get More Care, Less Quality, Says Latest Dartmouth Atlas
8. Cato Research Ltd. and Advanced Targeting Systems, Inc. Partner to Develop SP-SAP for Chronic Pain
9. Adolescents with chronic insomnia report twofold to fivefold increase in personal problems
10. Annual Economic Impact of Chronic Disease on Ohio Economy is $56.8 Billion
11. Data study suggests cortisol could alleviate for chronic fatigue syndrome and fibromyalgia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2017)... , ... February 19, 2017 , ... Braun Industries will ... Conference & Exposition, the event will take place February 23-25, 2017 at the Calvin ... be in Booth #909 with three new ambulances on display. , ...
(Date:2/19/2017)... ... 19, 2017 , ... "At your fingertips" electronic access to ... the Delaware Health Information Network (DHIN) have partnered to improve connectivity of this ... information exchange, DHIN stores and shares real-time health data for more than 2 ...
(Date:2/18/2017)... ... February 17, 2017 , ... ... Devicemakers , Sponsored by Axendia, **FDAnews Free Webinar**, March 1, 2017 — ... looking to reduce their regulatory burden? Pay dividends in enhanced and predictable ...
(Date:2/18/2017)... Lewisberry, PA (PRWEB) , ... February 17, 2017 , ... ... more about the Stannah Stairlift and other Butler products. Ken was impressed with ... team, and agreed to endorse the product on his show. This endorsement by ...
(Date:2/18/2017)... , ... February 17, 2017 , ... Park Cities Pet ... Behave” Show on the Pet Life Radio network. The episode, which was posted ... of topics including: what factors led to Park Cities Pet Sitter’s being awarded the ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... , Feb. 17, 2017  Noble Capital Markets announced ... Pharma Inc. (Nasdaq: EPIX ). The report ... Kumar Raja , PhD. ESSA Pharmaceuticals is ... resistant prostate cancer (CRPC). Its lead compound EPI-506, is ... amino-terminal domain of the androgen receptor, thereby has potential ...
(Date:2/16/2017)... -- DaVita Inc. (NYSE: DVA ) today announced ... Net income attributable to DaVita Inc. for ... million, or $0.80 per share and $880 million, or $4.29 ... to DaVita Inc. for the quarter and year ended December ... million, or $0.98 per share, and $789 million, or $3.85 ...
(Date:2/16/2017)... -- Newly published research from the CVS Health (NYSE: ... private retailer can play in restricting access to tobacco ... in the American Journal of Public Health , ... all CVS Pharmacy stores reduced the number of cigarette ... impact on those who bought cigarettes exclusively at CVS ...
Breaking Medicine Technology: