Navigation Links
Chronic Exposure to Solvents Disturbs Brain's Wiring

Changes in dopamine receptor density affects memory and psychomotor speed, study says

FRIDAY, April 18 (HealthDay News) -- Long-term exposure to solvents in products such as paints and dry cleaning agents may cause disturbances in the brain's wiring, researchers report.

These abnormalities play a role in a condition called chronic solvent-induced encephalopathy (CSE), the Dutch team conclude in the April issue of the Annals of Neurology.

People with CSE experience problems with memory, attention and psychomotor function long after exposure to solvents has ceased, according to background information in the study. Cases of CSE, a recognized occupational health problem, are increasing in a number of western nations.

This study found that disturbances within the brain's frontal-striatal-thalamic (FST) circuitry are related to the clinical characteristics of CSE, as well as to the severity of exposure to solvents.

The study included 10 CSE patients who'd been exposed to solvents and had mild to severe cognitive impairment, 10 people who'd been exposed to solvents but had no CSE symptoms, and 11 people with no exposure to solvents and no CSE symptoms.

All the participants underwent a number of tests, including MRI and single photon emission computed tomography (SPECT) scans to assess their FST circuitry.

The CSE patients had reduced striatal dopamine D2 receptor (D2R) binding ratios, which were predictive of impaired psychomotor speed and attention, and were also linked to solvent exposure severity, the study authors found. Dopamine receptor density is believed to play a role in psychomotor speed.

The 10 people who were exposed to solvents but had no CSE symptoms showed similar reductions but to a lesser extent. Both groups showed reduced levels of choline (which plays a role in neurotransmission) in the frontal grey matter of the brain.

The results indicate that certain parts of the FST circuitry are affected in CSE patients and in workers who've been exposed to solvents but don't have any CSE symptoms, the study authors said.

"A better understanding of the nature, severity and specificity of these suspected biological markers may further validate diagnostic procedures, this reinforcing medical and social recognition, and underlining the importance of prevention," wrote Ieke Visser, of the Academic Medical Center in Amsterdam, and colleagues.

More information

The U.S. National Library of Medicine has more about CSE.

-- Robert Preidt

SOURCE: Annals of Neurology, news release, April 15, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Overuse of Opioids, Barbiturates Boosts Chronic Migraine Risk
2. New Jersey Leaders Join Forces to Battle Chronic Disease
3. Disturbances in brain circuitry linked to chronic exposure to solvents
4. Potential blood test for chronic sinusitis identified
5. Studies Confirm Balloon Sinuplasty(TM) Helps Chronic Sinusitis Patients
6. Disease Management Programs that Focus on Needs of Chronically Ill Patients Can Provide Positive, Cost-Effective Results
7. Chronically Ill Patients Get More Care, Less Quality, Says Latest Dartmouth Atlas
8. Cato Research Ltd. and Advanced Targeting Systems, Inc. Partner to Develop SP-SAP for Chronic Pain
9. Adolescents with chronic insomnia report twofold to fivefold increase in personal problems
10. Annual Economic Impact of Chronic Disease on Ohio Economy is $56.8 Billion
11. Data study suggests cortisol could alleviate for chronic fatigue syndrome and fibromyalgia
Post Your Comments:
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and ... to be personalized through a fitness app. The fitness app plans to fix the two ... currently only offer a one size fits all type program , They don’t ...
(Date:6/25/2016)... ... ... Bruton Memorial Library on June 21 due to a possible lice infestation, as reported by ... lice: the parasite’s ability to live away from a human host, and to infest common ... the event that lice have simply gotten out of control. , As lice are a ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 2016 , , , WHEN: ... 2016 , , , , LOCATION: , , , Online, ... , , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global ... Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager ... pharmaceutical industry is witnessing an exceptional era. Several new demand spaces, ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas ... Brasil as the company,s second affiliate in Latin America . ... ... of Astellas Farma Colombia ... ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: