Navigation Links
Chromosome Linked to Diabetics' Heart Risks
Date:11/25/2008

Genetic variation identifies those with poor glucose control likely to have artery disease

TUESDAY, Nov. 25 (HealthDay News) -- Adding to earlier research, a new study has identified a genetic variation that increases the risk of coronary artery disease (CAD) in type 2 diabetes patients with poor sugar glucose (glycemic) control.

Previous research has found that genetic variations on a genetic chromosome known as chromosome 9p21 are associated with increased risk of CAD in the general population.

The team at the Joslin Diabetes Center at Harvard Medical School studied more than 1,500 people with type 2 diabetes (including 322 diagnosed with CAD) who were tested for a gene variation of chromosome 9p21 and checked for long-term glycemic control.

The findings were published in the Nov. 26 issue of the Journal of the American Medical Association.

Compared to patients with good glycemic control and no 9p21 gene risk variant, those subjects with two risk gene variants and good glycemic control were twice as likely to have CAD, while those with two risk gene variants and poor glycemic control were four times more likely to have CAD.

This association was strongest when long-term (seven years) glycemic control was measured in patients with two risk gene variants and a history of poor glycemia, and for patients with the same genotype but not long-term poor glycemia. The researchers also noted a similar interaction between the 9p21 variant and poor glycemia was associated with the death rate after 10 years.

"In conclusion, 9p21 (variant) and poor glycemic control interact in determining the odds of CAD in type 2 diabetes," Dr. Alessandro Doria and colleagues are quoted in a medical association news release. "This finding may have implications for our understanding of atherogenesis (the process of plaque forming in arteries) in diabetes and for the design of more effective prevention strategies. More broadly, it illustrates the complex etiology of multifactorial disorders and highlights the importance of accounting for gene-environment and gene-gene interactions in the quest for genetic factors contributing to these conditions."

Type 2 diabetes is one of the most significant risk factors for cardiovascular disease, and people with type 2 diabetes are two to four times more likely to suffer a major cardiac event than those without diabetes, according to background information in the article. According to the U.S. Centers for Disease Control and Prevention, more than 22 million Americans have type 2 diabetes.

More information

The U.S. National Institute of Diabetes, Digestive and Kidney Diseases has more about diabetes and heart disease and stroke.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, Nov. 25, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Grant Supports Study of Abnormal Ring-Shaped Chromosomes
2. Optherion Licenses Worldwide Rights to Develop Age-Related Macular Degeneration Diagnostics Based on Chromosome 10 Genetic Variations
3. Herceptin helps women with multiple chromosomes containing HER2 gene, study finds
4. Chromosome Abnormalities Raise Risk for Autism
5. Missing Chromosome Improves Response to Brain Tumor Treatment
6. Penn researchers identify first sex chromosome gene involved in meiosis and male infertility
7. Research shines spotlight on a key player in the dance of chromosomes
8. Pot bellies linked to early signs of cardiovascular disease
9. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
10. Immune deficiency linked to a type of eye cancer
11. Drop in breast cancer incidence linked to hormone use, not mammograms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chromosome Linked to Diabetics' Heart  Risks
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice ... "Film editors can give their videos a whole new perspective by using the ... of Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to ...
(Date:6/25/2016)... ... June 25, 2016 , ... Austin residents seeking Mohs ... College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical dermatology. ... treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by Dr. ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/24/2016)... ... 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. In ... benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has issued ... Sickle Cell Disease (SCD) is a disorder of the red blood cells, which can ...
(Date:6/24/2016)... San Diego, CA (PRWEB) , ... June 24, 2016 , ... ... up with the American Cancer Society and the Road To Recovery® program to drive ... care to seniors and other adults to ensure the highest quality of life and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... 2022" report to their offering. ... with kidney failure, it replaces the function of kidneys by ... and thus the treatment helps to keep the patient body,s ... Increasing number of ESRD patients & substantial healthcare ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: ... 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) assay ... sepsis or septic shock. With this clearance, Roche is ... a fully integrated solution for sepsis risk assessment and ... with bacterial infection and PCT levels in blood can ...
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
Breaking Medicine Technology: