Navigation Links
Chromosome Linked to Diabetics' Heart Risks
Date:11/25/2008

Genetic variation identifies those with poor glucose control likely to have artery disease

TUESDAY, Nov. 25 (HealthDay News) -- Adding to earlier research, a new study has identified a genetic variation that increases the risk of coronary artery disease (CAD) in type 2 diabetes patients with poor sugar glucose (glycemic) control.

Previous research has found that genetic variations on a genetic chromosome known as chromosome 9p21 are associated with increased risk of CAD in the general population.

The team at the Joslin Diabetes Center at Harvard Medical School studied more than 1,500 people with type 2 diabetes (including 322 diagnosed with CAD) who were tested for a gene variation of chromosome 9p21 and checked for long-term glycemic control.

The findings were published in the Nov. 26 issue of the Journal of the American Medical Association.

Compared to patients with good glycemic control and no 9p21 gene risk variant, those subjects with two risk gene variants and good glycemic control were twice as likely to have CAD, while those with two risk gene variants and poor glycemic control were four times more likely to have CAD.

This association was strongest when long-term (seven years) glycemic control was measured in patients with two risk gene variants and a history of poor glycemia, and for patients with the same genotype but not long-term poor glycemia. The researchers also noted a similar interaction between the 9p21 variant and poor glycemia was associated with the death rate after 10 years.

"In conclusion, 9p21 (variant) and poor glycemic control interact in determining the odds of CAD in type 2 diabetes," Dr. Alessandro Doria and colleagues are quoted in a medical association news release. "This finding may have implications for our understanding of atherogenesis (the process of plaque forming in arteries) in diabetes and for the design of more effective prevention strategies. More broadly, it illustrates the complex etiology of multifactorial disorders and highlights the importance of accounting for gene-environment and gene-gene interactions in the quest for genetic factors contributing to these conditions."

Type 2 diabetes is one of the most significant risk factors for cardiovascular disease, and people with type 2 diabetes are two to four times more likely to suffer a major cardiac event than those without diabetes, according to background information in the article. According to the U.S. Centers for Disease Control and Prevention, more than 22 million Americans have type 2 diabetes.

More information

The U.S. National Institute of Diabetes, Digestive and Kidney Diseases has more about diabetes and heart disease and stroke.



-- Robert Preidt



SOURCE: Journal of the American Medical Association, news release, Nov. 25, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Grant Supports Study of Abnormal Ring-Shaped Chromosomes
2. Optherion Licenses Worldwide Rights to Develop Age-Related Macular Degeneration Diagnostics Based on Chromosome 10 Genetic Variations
3. Herceptin helps women with multiple chromosomes containing HER2 gene, study finds
4. Chromosome Abnormalities Raise Risk for Autism
5. Missing Chromosome Improves Response to Brain Tumor Treatment
6. Penn researchers identify first sex chromosome gene involved in meiosis and male infertility
7. Research shines spotlight on a key player in the dance of chromosomes
8. Pot bellies linked to early signs of cardiovascular disease
9. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
10. Immune deficiency linked to a type of eye cancer
11. Drop in breast cancer incidence linked to hormone use, not mammograms
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Chromosome Linked to Diabetics' Heart  Risks
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions ... initiated cultivation and processing operations at its production facility, and opened its first ... is the manufacturer of a complete system of proactive air and surface purification ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)...  VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ) reported ... required to build a strong and stable market for ... on the OTC Markets-pink current trading platform. ... are seeing an anomaly in market trading activities that ... the Company, but shareholders and market players as well. ...
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
Breaking Medicine Technology: