Navigation Links
Chromosome 21 abnormality tells oncologists to treat pediatric ALL more aggressively
Date:8/20/2013

A recent study by members of the Children's Oncology Group reports results of a large trial showing that children whose leukemia cells have amplification of a portion of chromosome 21 may require more aggressive treatment for Acute Lymphoblastic Leukemia (ALL) than children without this gene amplification.

"This helps identify patients who need more therapy than they may otherwise get," says Stephen Hunger, MD, investigator at the University of Colorado Cancer Center, professor of pediatrics at the University of Colorado School of Medicine, and director of the Center for Cancer and Blood Disorders at Children's Hospital Colorado.

Hunger notes that this genetic abnormality was first described in 2003 and has subsequently been found in about 2 percent of pediatric ALL patients. Initial reports described poor outcomes for small groups of children with this abnormality, but the current study is by far the largest and shows the importance of this genetic abnormality even with modern treatments. The study documents the treatments and outcomes of more than 8,000 cases of pediatric ALL.

"What we found is that when this genetic abnormality is present in children with good risk features who get a standard level of treatment, there is more treatment failure than with similar, low-risk kids who don't have this genetic marker. But with kids whose risk features already dictate more aggressive treatment, this genetic abnormality doesn't seem to be associated with a worse outcome, because kids are already getting the appropriate treatment. Recognizing this abnormality could help us treat even otherwise low-risk kids more aggressively up front leading to improved cure rates," Hunger says.

Specifically, the genetic abnormality is defined as four or more copies of the gene RUNX1, located on an abnormal chromosome 21. And this amplification is already detected as a byproduct of another genetic test standard in pediatric ALL, namely a test for fusion of this RUNX1 gene with the gene ETV6.

"In a sense, the testing comes for free with other testing you're already doing," Hunger says.

A study published by the same group in 2012 showed that pediatric ALL cure rates are at or above 90.4 percent.

"In early 1960s this disease was incurable," Hunger says. "Then in the late 1960s, the cure rate was 10 percent. Now 90 percent of children and adolescents diagnosed with ALL will be cured. Still, a 90-percent survival rate is little consolation to the 10 percent of families whose child doesn't survive. There's still more work to be done."


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Warwick scientists uncover how checkpoint proteins bind chromosomes
2. Mutations impair childhood growth and development by disrupting organization of chromosome pairs
3. Documenting womens experiences with chromosome abnormalities found in new prenatal test
4. Research reveals new understanding of X chromosome inactivation
5. Caloric restriction has a protective effect on chromosomes
6. Scientists discover how chromosomes keep their loose ends loose
7. Blame Common Colds on Your Chromosome Caps?
8. New Comprehensive Chromosome Screening Program at Pacific Fertility Center Refines Embryo Selection, Improves Pregnancy Rates
9. Dual systems key to keeping chromosomes intact
10. Spanish researchers link cancer to failures in chromosome protection for the first time
11. Study Pinpoints New Abnormality in Athletes Heart
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... August 19, 2017 , ... Physician Partners of America Pain ... an interventional pain management physician. He brings a wealth of pain management experience ... and significant experience in spinal cord stimulation for chronic pain. , Dr. Ahmed ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... LLC (“Quick”), a highly specialized asset-light logistics provider of complex transport solutions ... definitive agreement to purchase Unitrans International Corporation, a division of Roadrunner Transportation ...
(Date:8/18/2017)... ... ... The Dawn Johnson Insurance Group, a Missouri-based insurance and financial planning firm ... for efforts to educate the local population on cancer realities while attracting donations to ... , Each day in America, roughly 4,600 new cases of cancer are diagnosed and ...
(Date:8/18/2017)... Saint John, IN (PRWEB) , ... August 18, 2017 , ... ... services to communities in northwest Indiana, is campaigning in support of Campagna Academy in ... Formerly referred to as the “Hoosier Boys’ Town of Indiana,” Campagna Academy is a ...
(Date:8/18/2017)... ... 18, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, ... on false teachings pertaining to the mother of the Savior whom the world calls “Mother ... different picture of the role of this historical woman. , “The world bows, kisses ...
Breaking Medicine News(10 mins):
(Date:8/3/2017)... Aug. 3, 2017  Opioid addiction and other drugs ... healthcare costs and threatening outcomes, were problems taken on ... IVD industry that support them, met this week. This ... said that drugs of abuse, procalcitonin and acute kidney ... the organization,s 69th meeting in San Diego, ...
(Date:8/2/2017)... and BENTON, Ky. , Aug. 2, 2017   Marshall ... to its environmental services (ES) team to proactively reduce the risk of hospital-acquired infections (HAIs). ... UV disinfection robot that uses UVC light energy to kill deadly pathogens such as ... Tru-D ... Tru-D in action ...
(Date:8/2/2017)... Aug. 2, 2017 CaryRx, a next-generation full-service pharmacy, ... service for patients in the Washington D.C. ... pharmacy by providing delivery of medications through the convenience of ... delivery or delivered within one hour to any location in ... to bring this invaluable service to Washington D.C. ...
Breaking Medicine Technology: