Navigation Links
Chromatin remodeling complex connected to DNA damage control
Date:8/13/2007

HOUSTON - When molecular disaster strikes, causing structural damage to DNA, players in two important pathways talk to each other to help contain the wreckage, scientists at The University of Texas M. D. Anderson Cancer Center report in the August edition of Cell.

This connection between a signaling pathway crucial to DNA damage control and a pathway known as chromatin remodeling "opens an entirely new category of targets for potentially attacking cancer," says senior author Xuetong "Snow" Shen, Ph.D., an assistant professor in M. D. Anderson's Department of Carcinogenesis at the Science Park - Research Division in Smithville, Texas.

If DNA damage is like a fire that spreads when impaired cells divide and multiply, then the DNA checkpoint and repair system can be considered a first-response firebreak. Checkpoint genes temporarily halt a cell's division and assess its DNA. The "fire" is either doused by DNA repair or by programmed destruction of the cell.

The ATM/ATR kinases are known to regulate DNA repair and checkpoint pathways, Shen explains, by attaching phosphate groups to other proteins involved in damage control. When ATM and ATR are themselves damaged, they cause genome instability and fuel cancer growth.

"We found that one of the proteins phosphorylated was a unit of a chromatin remodeling complex we call INO80," Shen says. "We subsequently found that phosphoryllation of this subunit regulates checkpoint pathways, but not DNA repair pathways."

A cell's DNA resides in chromosomes found in the cell nucleus, but it's a bit more complex than just DNA itself, Shen explains. DNA is tightly intertwined with proteins known as histones and assembled in histone/DNA units called nucleosomes along the connecting length of a string of DNA.

"This structure is often referred to as beads on a string," Shen says, and is collectively known as chromatin.

"Chromatin creates barriers to DNA against anything t
'/>"/>

Contact: Scott Merville
sdmervil@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. MRI, To Detect Remodeling Of Heart and Help Preserve Function
2. Protein Complex prevents cancer
3. Bush’s new prescription drug plan, a complex puzzle for the citizen
4. Human Complexity Can Be Attributed To Regulatory Sequence
5. Mystery behind Complex Regional Pain Syndrome Unraveled
6. Scientists Explain Complex Darwinian Evolution
7. Complex Surgery Performed on Eight-Month-Old Egyptian Girl
8. Complex Apnea May Explain Sleepless Nights
9. Slow brain waves integral in coordination of complex activity
10. Picture Book Reading Helps Toddlers Grasp Complex Actions
11. Scientists Uncover Complex Workings of Sperm
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Texas (PRWEB) April 27, 2015 Fitness ... the Nation, is starting a health and fitness revolution, ... the fight against obesity. For several years, Houston, the ... one of the fattest cities in America. With help ... and make it one of the fittest and healthiest ...
(Date:4/27/2015)... Los Angeles, CA (PRWEB) April 27, 2015 ... titled “How to Get Rid of Stretch Marks ,” ... stretch marks . Stretch marks are a ... women. Stretch marks are caused by a breakdown of the ... beneath the epidermis. (see: goo.gl/iRdmEe) , “Stretch mark removal ...
(Date:4/27/2015)... According to a recent report from NIDCR ... back pain, TMJ disorders are the second most ... In addition, the report revealed that TMJ disorders affect ... an estimated 4 billion dollars annually. , These estimates ... unrelated symptoms such as headaches, neck pain, tenderness of ...
(Date:4/27/2015)... Thanks to a $7.5 million grant ... half-dozen institutions, including American University, will operate in a ... and behavioral research aimed at ending the AIDS epidemic. ... with HIV or AIDS, according to the latest statistics. ... population over the age of 13 was living with ...
(Date:4/27/2015)... 27, 2015 Doctors on Liens ... a lien basis for over twenty years. So when attorneys ... best doctor in the Fresno area , Doctors on ... and his team of medical specialists. With a medical ... therapist, Dilanchian Chiropractic is now helping more personal ...
Breaking Medicine News(10 mins):Health News:Houston Celebrities Take a Stand and Rebel Against Obesity 2Health News:Stretch Marks: The Latest Treatment Options for Stretch Mark Removal 2Health News:Dentist in Graham NC Reveals that a Jaw Disorder May Be the Cause of Chronic Headaches and Back Pain 2Health News:D.C. Center for AIDS Research Established with New Grant from NIH 2Health News:D.C. Center for AIDS Research Established with New Grant from NIH 3Health News:Eminent Doctor Joins Forces with Doctors on Liens in Fresno 2
... a recognized leader in providing turnkey electronic billing ... announced today that it has signed an agreement ... Corporation, to provide electronic clearinghouse services for Aon ... will enable Aon eSolutions, clients and medical providers ...
... highlights new hospitalist HIDI(TM) process at the 2009 ... ExecutivesSEATTLE, March 23 Hospital executives find themselves ... percent of America,s hospitals now operating at a ... Hospital leaders seek to control costs while maintaining ...
... Adds Advanced Drug Safety and Risk Management Applications to Extend ... News Facts , , ... that it has agreed to acquire Relsys International, Inc. ("Relsys"), ... with advanced analytics for the health sciences industry. , ...
... Volumes Seen in Houston Physician-Owned Hospitals, According ... 23 HealthLeaders-InterStudy, a leading provider of ... Texas laws favoring physicians have traditionally enabled ... directly with health systems, these regulations may ...
... (Nasdaq: WBMD ), the leading provider of ... a long-term strategic relationship with Boots UK Limited, the ... Kingdom, to jointly develop a consumer health and wellness ... will leverage WebMD,s online consumer health assets and expertise ...
... 23 Dr. Kevin Polk, a clinical psychologist with ... offering a new web program and DVD for stress ... Training (ACT). It emphasizes decreasing struggling with stress and ... traditional stress management techniques such as deep breathing and ...
Cached Medicine News:Health News:WorkCompEDI Announces Agreement with Aon eSolutions for Electronic Billing Services 2Health News:Sound Inpatient Physicians Report on New Clinical Processes to Reduce Healthcare Costs and Enhance Care 2Health News:Oracle Buys Relsys 2Health News:Oracle Buys Relsys 3Health News:In Texas, Favorable Regulations for Physicians May Backfire in Light of Market Downturn 2Health News:WebMD Announces Strategic Relationship with Boots UK to Launch New Consumer Health Portal in UK 2Health News:WebMD Announces Strategic Relationship with Boots UK to Launch New Consumer Health Portal in UK 3Health News:Surfing Your Stress to Success Program Offers a New Way of Dealing with Stress 2
(Date:4/27/2015)... 2015  Recognizing the unique position Massachusetts ... the most respected organizations in the New England medtech community, ... Industry Council (MassMEDIC), have partnered to celebrate the region,s ... Annual Massachusetts Medtech Week. This celebration will take place May ... Center in Boston . For more information ...
(Date:4/27/2015)... Mass. , April 27, 2015 ... a collaboration with Brainlab AG, a leading software-driven ... planning and surgical navigation. The collaboration provides patients ... Stimulation (DBS) therapy. DBS is intended to treat ... help reduce symptoms for movement disorders such as ...
(Date:4/27/2015)... , April 27, 2015  CryoLife, Inc. (NYSE: ... processing company focused on cardiac and vascular surgery, announced ... the United States Food and Drug Administration ("FDA") verifying ... in place following the warning letter it received from ... letter follows a re-inspection in March 2015 by the ...
Breaking Medicine Technology:First Annual Massachusetts Medtech Week Celebrated this May 2First Annual Massachusetts Medtech Week Celebrated this May 3Boston Scientific Announces Strategic Collaboration With Brainlab AG 2Boston Scientific Announces Strategic Collaboration With Brainlab AG 3Boston Scientific Announces Strategic Collaboration With Brainlab AG 4CryoLife Announces Resolution of FDA Warning Letter 2
... for,rheumatoid arthritis (RA) have ushered in a new ... The findings are,reported in a New Drug Class ... of The Lancet. , RA is the most ... of the,population in the industrialised world. Its typical ...
... WIRE)--Jun 13, 2007 - EPIX,Pharmaceuticals, Inc. (NASDAQ: EPIX) ... of PRX-00023, a novel long-acting 5-HT1A agonist,was featured ... New,Clinical Drug Evaluation Unit (NCDEU) Meeting in Boca ... Institutes of,Health and the American Society of Clinical ...
Cached Medicine Technology:Three New Drugs Mark New Era in Rheumatoid Arthritis Treatment 2Three New Drugs Mark New Era in Rheumatoid Arthritis Treatment 3EPIX Pharmaceuticals Presents Findings from PRX-00023 Phase 3,Clinical Trial at 47th Annual NCDEU Meeting 2EPIX Pharmaceuticals Presents Findings from PRX-00023 Phase 3,Clinical Trial at 47th Annual NCDEU Meeting 3EPIX Pharmaceuticals Presents Findings from PRX-00023 Phase 3,Clinical Trial at 47th Annual NCDEU Meeting 4
Set of six replacement burrs for E0824 Storz corneal burr set. Dull finish. Most popular size or model....
Replacement burr for E0819A or E0819B Algerbrush rust ring remover. Dull finish....
0.5 mm replacement burr for Algerbrush rust ring remover (E0815 A). Burr can also be used with Algerbrush rust ring remover (E0815 B). Dull finish....
5.5 mm disk shape burr. Diamond coated tip. Use with E0824 B handle....
Medicine Products: