Navigation Links
Cholesterol-lowering drugs also may protect stem cell transplant patients from GVHD
Date:12/4/2009

SEATTLE Cholesterol-lowering drugs known as statins are among the most prescribed medicines in the U.S. Now a new study by researchers at Fred Hutchinson Cancer Research Center indicates that statins may protect stem cell transplant patients from one of the most serious complications of the life-saving cancer therapy: graft-versus-host disease, or GVHD. The findings are reported in the Nov. 4 first edition of the journal Blood.

In a retrospective study of 567 patients who underwent hematopoietic cell transplantation from matched sibling donors between 2001 and 2007, patients whose donors had been taking statins at the time of stem cell donation experienced no severe acute GVHD. About 15 percent of the stem cell donors in the study were taking statins at the time of transplant.

Normally, between 10 percent and 15 percent of transplant patients would be expected to develop severe acute GVHD, according to the study's senior author Marco Mielcarek, M.D., an assistant member of the Hutchinson Center's Clinical Research Division.

No such protection from severe acute GVHD was observed if only the patient was taking a statin, according to the study. There was some indication that protection against severe GVHD was even stronger when both patient and donor had been on statin medications, however the number of patients in this group was too small to be statistically significant.

The researchers also found that only those transplant patients with statin-treated donors who received cyclosporine-based immunosuppression therapy after transplantation were protected from severe GVHD. Patients with statin-treated donors who received a similar drug, tacrolimus, did not experience the same GVHD-protection. The study also found that the greatest statin protection occurred against severe GVHD of the gastrointestinal tract.

GVHD is a common side effect in patients who receive blood stem cell transplants from related or unrelated d
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cholesterol-lowering medicines may be effective against cancer
2. Triglyceride Levels Continue to Rise in the United States Despite Increased Use of Cholesterol-Lowering Medications
3. Cholesterol-lowering drugs may also lower PSA, but whether they cut cancer risk is still not known
4. Discoverers of Small Regulatory RNAs and Cholesterol-Lowering Drugs to Receive Lasker Awards for Medical Research
5. Study shows cholesterol-lowering power of dietitian visits
6. Cholesterol-Lowering Statins Tied to Tendon Woes
7. Cholesterol-Lowering Drugs May Ease Irregular Heartbeat
8. New Type of Cholesterol-Lowering Drug Shows Promise
9. Many Patients Stop Taking Cholesterol-Lowering Drugs
10. Cholesterol-lowering drug linked to sleep disruptions
11. Diabetes Drugs Go Head-to-Head in Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... MANHASSET, NY In a review published in the ... MD, president of The Feinstein Institute for Medical Research, ... the medical community,s approach to treating sepsis, ... 200,000 Americans. , Sepsis occurs when molecules released into ... inflammation throughout the body. Inflammation is necessary for maintaining ...
(Date:4/17/2014)... has created a new technology for modifying human ... the body and selectively target cancer and other ... that monitor and modify human physiology is a ... existing technology enabled bioengineers to build such devices ... in a customized fashion. , "The project addressed ...
(Date:4/17/2014)... (April 17, 2014) Doctors who treat patients ... lymphangioleiomyomatosis (LAM) can face an agonizing treatment decision. ... the disease and help relieve shortness of breath. ... and sirolimus can cause potentially fatal complications following ... Dr. Daniel Dilling, medical director of Loyola University ...
(Date:4/17/2014)... The cause of neuronal death in Parkinson,s disease ... neurons may be mistaken for foreign invaders and killed ... way autoimmune diseases like type I diabetes, celiac disease, ... was published April 16, 2014, in Nature Communications ... idea in Parkinson,s disease; but if true, it could ...
(Date:4/17/2014)... a new mechanism that allows blood to enter the ... and the Salk Institute have opened the door to ... damage. , A complex and devastating neurological condition, stroke ... for disability in the U.S. The blood-brain barrier is ... into the brain, causing the permanent deficits in movement ...
Breaking Medicine News(10 mins):Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Building 'smart' cell-based therapies 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:Is Parkinson's an autoimmune disease? 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2
... Minority Quality Forum Launches First U.S. HIV/AIDS Atlas , ... today launched a groundbreaking HIV/AIDS Atlas ( http://www.MapHIV.org ... epidemic in communities across the United States. The Atlas ... location for the first time, painting a comprehensive picture of ...
... Perfect Time for Fitness! , , LOS ANGELES, June 22 ... in the park or along the beach. Now a brand new ... fitness equipment on wheels, but with a unique design to allow ... a new concept of fitness, will be introduced to California starting ...
... , DentaBurst(TM) delivers an on-the-go oral care solution to ... NEW YORK, June 22 Crown Consumer Brands today ... the original proven technology will remain intact, an improved, ... will accompany this highly anticipated re-launch. , ...
... MUSCLEPHARM(R) LLC, the rising star of the Sports Nutrition ... through each of Vitamin Shoppe,s 400+ locations nationwide. , ... launch of our entire line of products," MUSCLEPHARM president ... athletes in nearly every neighborhood across the nation! Vitamin ...
... Transcend Medical, Inc., an ophthalmic device company dedicated ... announced today that it has closed a $35 million ... of its Transcend CyPass(TM) System, a novel proprietary system ... Lead investor HLM Venture Partners, along with other new ...
... Magnetic Resonance Center of the University Children,s Hospital ... in MR-guided, non-invasive neurosurgery. Ten patients have been ... ultrasound. This fully non-invasive procedure opens new horizons ... brain disorders. In the context of a ...
Cached Medicine News:Health News:MapHIV.org Shows 18% of Georgia's Counties are Seriously Impacted by HIV 2Health News:MapHIV.org Shows 18% of Georgia's Counties are Seriously Impacted by HIV 3Health News:Pumgo Fitness Scooter Will Highlight Venice Beach This Summer 2Health News:Crown Consumer Brands Re-Launches DentaBurst(TM) Freshening Teeth Cleaners 2Health News:MUSCLEPHARM Products Hit Vitamin Shoppe Shelves With a Bang! 2Health News:Transcend Medical Raises $35 Million Series B Round Towards Development of Novel Glaucoma Treatment 2Health News:Successful neurosurgery with transcranial MR-guided high-intensity focused ultrasound 2Health News:Successful neurosurgery with transcranial MR-guided high-intensity focused ultrasound 3
(Date:1/15/2014)... AARP Foundation today announced it has established a ... severe cold weather that has gripped much of the nation. ... need; so to support these emergency relief efforts AARP and ... could mean up to $500,000 in aid. The matching program ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces that ... to the announced tender offer for all of the outstanding shares ... of the waiver, the transaction is no longer conditional on OFT ... 24, 2014 following the currently scheduled expiration time, subject to the ...
(Date:1/15/2014)... 2014  In an unprecedented effort to curb the spread of "superbugs" ... transport vehicles, an advanced and portable UV germicidal lamp manufactured by ... time. In order to prevent EMS paramedics and ... West Palm Beach Fire Rescue is the first ...
Breaking Medicine Technology:AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Superbugs No Longer Ride In Rescue Vehicles 2
... Oct. 27 Pharmos Corporation (Pink Sheets: PARS ... nine-month period ended September 30, 2010. These results are included ... been filed with the SEC. During the quarter ... potential partners for Dextofisopam, its drug for irritable bowel syndrome ...
... N.J., Oct. 27 Systech International, innovator of ... Pac Automation, a leading supplier of end-of-line packaging ... integrated solution for global serialization requirements at Pack ... attendees have the opportunity to examine first hand ...
Cached Medicine Technology:Pharmos Corporation Reports 2010 Third Quarter Results 2Pharmos Corporation Reports 2010 Third Quarter Results 3Pharmos Corporation Reports 2010 Third Quarter Results 4Systech and Pester Pac Automation Exhibit Integrated Serialization Solution at Pack Expo 2010 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: