Navigation Links
Cholesterol-lowering drugs also may protect stem cell transplant patients from GVHD
Date:12/4/2009

SEATTLE Cholesterol-lowering drugs known as statins are among the most prescribed medicines in the U.S. Now a new study by researchers at Fred Hutchinson Cancer Research Center indicates that statins may protect stem cell transplant patients from one of the most serious complications of the life-saving cancer therapy: graft-versus-host disease, or GVHD. The findings are reported in the Nov. 4 first edition of the journal Blood.

In a retrospective study of 567 patients who underwent hematopoietic cell transplantation from matched sibling donors between 2001 and 2007, patients whose donors had been taking statins at the time of stem cell donation experienced no severe acute GVHD. About 15 percent of the stem cell donors in the study were taking statins at the time of transplant.

Normally, between 10 percent and 15 percent of transplant patients would be expected to develop severe acute GVHD, according to the study's senior author Marco Mielcarek, M.D., an assistant member of the Hutchinson Center's Clinical Research Division.

No such protection from severe acute GVHD was observed if only the patient was taking a statin, according to the study. There was some indication that protection against severe GVHD was even stronger when both patient and donor had been on statin medications, however the number of patients in this group was too small to be statistically significant.

The researchers also found that only those transplant patients with statin-treated donors who received cyclosporine-based immunosuppression therapy after transplantation were protected from severe GVHD. Patients with statin-treated donors who received a similar drug, tacrolimus, did not experience the same GVHD-protection. The study also found that the greatest statin protection occurred against severe GVHD of the gastrointestinal tract.

GVHD is a common side effect in patients who receive blood stem cell transplants from related or unrelated d
'/>"/>

Contact: Dean Forbes
dforbes@fhcrc.org
206-667-2896
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Cholesterol-lowering medicines may be effective against cancer
2. Triglyceride Levels Continue to Rise in the United States Despite Increased Use of Cholesterol-Lowering Medications
3. Cholesterol-lowering drugs may also lower PSA, but whether they cut cancer risk is still not known
4. Discoverers of Small Regulatory RNAs and Cholesterol-Lowering Drugs to Receive Lasker Awards for Medical Research
5. Study shows cholesterol-lowering power of dietitian visits
6. Cholesterol-Lowering Statins Tied to Tendon Woes
7. Cholesterol-Lowering Drugs May Ease Irregular Heartbeat
8. New Type of Cholesterol-Lowering Drug Shows Promise
9. Many Patients Stop Taking Cholesterol-Lowering Drugs
10. Cholesterol-lowering drug linked to sleep disruptions
11. Diabetes Drugs Go Head-to-Head in Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 2014 My Clients Plus ( http://www.MyClientsPlus.com ... The new module enables easy administration and routing ... quality care. , This application allows users such as ... attach a to-do item to a specific client, categorize ... up reoccurring reminders for follow-ups. It's designed to ...
(Date:10/20/2014)... Succeed is proud to announce that they ranked in the ... Every Body Walk! campaign by Kaiser Permanente. Every ... to be more active outside of the workplace. This ... end of September, was a friendly competition between organizations across ... companies gave their staff pedometers and each day, for the ...
(Date:10/20/2014)... 20, 2014 It’s hard to imagine what ... and vulnerable children around the world, it’s a reality. And ... many children are forced to walk barefoot on rocky terrain ... or play with their friends. , Buckner International's ... Air1 Radio in October to encourage support for Air1 ...
(Date:10/19/2014)... The leading review website, Top10BestSEOHosting.com, ... and GreenGeeks are the best Dedicated Server Hosting ... who want to buy high quality hosting and ... IT manager of Top10BestSEOHosting.com says, “We believe that ... for everyone. A lot of the global clients ...
(Date:10/19/2014)... 2014 Recently, Top10BestSEOHosting.com has unveiled ... JustHost, GoDaddy and HostMonster are the best VPS ... Private Server) is the method of partitioning a ... which has the appearance and capabilities of running ... the site pays close attention to VPS products ...
Breaking Medicine News(10 mins):Health News:My Clients Plus Announces New Workflow Management Software 2Health News:Succeed Management Solutions, LLC Competes in Walking Challenge and Achieves 12th Place in Portland 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 2Health News:Buckner Shoes for Orphan Souls® Garners Support from Air1 Radio 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2
... Nutrition Test Report Outlines an Individual,s Susceptibility to ... March 17 Interleukin Genetics, Inc. (NYSE Alternext ... a new, detailed report format and information package ... that enables easy understanding of an individual,s genetic ...
... FDA, a specialty blog written by Mark Senak, Senior Vice President at ... FDA,s DDMAC in charge of Web 2.0 policy development providing insight into ... in Web 2.0 by the pharmaceutical industry. , ... Washington, DC (PRWEB) ...
... AKRON, Ohio, March 17 Help is now just ... and hospice nurses and other medical professionals caring for ... or complex illness.The Comfort Line is a medical advice ... the assistance of the Ohio Pediatric Palliative Care and ...
... Reports Best Drugs For Less Magazine Rates 200 MedicationsYONKERS, N.Y., March ... they fill their prescriptions: 66% of those polled by Consumer ... when they picked it up at the pharmacy counter, while just ... cost of a drug. And 28% of Americans told ...
... panic. The following summarizes a new list of suggestions ... non-partisan National Center for Policy Analysis. Authored by NCPA ... full article is not sponsored by any commercial entity, ... Link to full article: http://www.ncpa.org/pdfs/Seven_Ways_Job_3-16-09-FINAL-A.pdf Here ...
... controversy involving a California woman who gave birth to ... In Vitro Fertilization to fear they may end up ... Specialist says not only is the California case unusual, ... in order to ensure IVF treatments are safe, and ...
Cached Medicine News:Health News:Improved Genetic Test Product Empowers Individuals to Better Understand Their Unique Nutritional Needs 2Health News:Improved Genetic Test Product Empowers Individuals to Better Understand Their Unique Nutritional Needs 3Health News:FDA's DDMAC Provides Insight on Pharmaceutical Companies and Web 2.0 in Eye on FDA Podcast 2Health News:'Comfort' Now Available to Caregivers of Ohio's Seriously-Ill Children 2Health News:Consumer Reports Poll: 66% of Americans Blindsided by Cost of Drugs; Many Not Taking Needed Medications 2Health News:Consumer Reports Poll: 66% of Americans Blindsided by Cost of Drugs; Many Not Taking Needed Medications 3Health News:Consumer Reports Poll: 66% of Americans Blindsided by Cost of Drugs; Many Not Taking Needed Medications 4Health News:7 Ways to Keep Health Coverage If You Lose Your Job 2Health News:Washington DC-area IVF Specialist Suheil Muasher, MD Addresses Fears of Infertility Treatments after Octuplet Mom News 2Health News:Washington DC-area IVF Specialist Suheil Muasher, MD Addresses Fears of Infertility Treatments after Octuplet Mom News 3Health News:Washington DC-area IVF Specialist Suheil Muasher, MD Addresses Fears of Infertility Treatments after Octuplet Mom News 4
(Date:10/17/2014)... , Oct. 17, 2014  Ameritox SM , the ... appointment of Thomas Smith , M.D., as Chief ... field-based team offering scientific resources for healthcare providers, patients ... held leadership positions at a variety of healthcare companies ... both the pain and behavioral health sides of Ameritox,s ...
(Date:10/17/2014)...   ndd Medical Technologies , a leader in ... technology, announced that its EasyOne Pro® is now being ... a 140,000 square foot, 44-bed hospital with many outpatient ... serves a large number of Native Americans from several ... and beyond. A portion of its funding comes from ...
(Date:10/17/2014)... , Oct. 17, 2014  STAAR Surgical Company (NASDAQ: ... implantable lenses and delivery systems for the eye, today announced ... Breakfast Meeting on Saturday, October 18, 7:00 a.m. CT at ... Chicago, IL. Dr. Erik ... Centre in Antwerp, Belgium , will present ...
Breaking Medicine Technology:Ameritox Appoints New Chief Medical Officer 2EasyOne Pro Mobile Respiratory Testing from ndd Medical Technologies Chosen by Choctaw Nation 2STAAR Surgical to Webcast Investor Presentations at American Academy of Ophthalmology's Annual Meeting 2STAAR Surgical to Webcast Investor Presentations at American Academy of Ophthalmology's Annual Meeting 3
... Finland, May 29, 2012 Oncos Therapeutics today ... of CGTG-102, an oncolytic adenovirus suggested as a potential new ... have already completed the safety assessment part of the study. ... clinic in No r thern Europe to start ...
... -- Clinilabs, an early phase and specialty CRO ... industry, today announced that they have opened a second ... capacity, 15,000 square foot Specialty Pharma Phase I Unit ... a bioanalytic laboratory, pharmacy, and exam rooms. ...
Cached Medicine Technology:Oncos Therapeutics Initiates Phase I Clinical Study of CGTG-102, an Oncolytic Adenovirus for the Treatment of Solid Tumor Cancers 2Clinilabs Opens Phase I Unit In Eatontown, New Jersey 2
Rees bayonet forceps, standard, 5-1/2", TC....
Medpor 2/3 Orbit implants are designed to replace non load bearing bony structures in the orbital area....
... Rim Implants provide the surgeon ... augmentation of the inferior and ... or secondary rim repair. The ... projection and extends around the ...
... Round handle. Divides nucleus for phacoemulsification. Nuclear ... any hardness can be pre-chopped with pre-chop ... nuclear fragments is rapid. Risk of rupturing ... ultra sound time and minimal movement of ...
Medicine Products: