Navigation Links
Cholesterol-lowering drug shrinks enlarged prostates in hamster model
Date:10/21/2010

Boston, Mass. - A cholesterol-lowering drug reduced the enlarged prostates of hamsters to the same extent as a drug commonly used to treat benign prostatic hyperplasia (BPH), report researchers at Children's Hospital Boston and their colleagues in the October issue of the Journal of Urology. Together, the drugs worked even better.

"We don't know the mechanism, but the results suggest to us that lowering cholesterol has the potential to reduce BPH in men," says senior author Keith Solomon, PhD, a biochemist, and member of the departments of Orthopaedic Surgery and Urology at Children's. "This brings up the possibility that other cholesterol lowering therapies, including exercise and diet, may prevent BPH from developing."

For unknown reasons, about half of men older than 50 (and 80 percent of men aged 80) develop BPH, most often evident as enlargement of the prostate. BPH leads to difficult urination, urgency, pain, and other symptoms that can cause significant reduction in the quality of life. In advanced stages, BPH can lead to renal failure. Standard medical and surgical treatments typically target the prostate and usually result in a reduction of symptoms but not without significant side effects in some men, Solomon said.

The study implicates circulating cholesterol in the progression of the condition and suggests a potential new strategy for prevention and treatment. The latest findings emerge from experiments with a strain of Syrian hamsters that undergo prostate enlargement naturally.

Led by first author Kristine Pelton, the team tested ezetimibe, an FDA-approved hypercholesterolemic drug (Zetia; Merck) against finasteride (Proscar, Propecia; Merck), a standard therapy for the treatment of BPH. Ezetimibe reduced prostatic enlargement in aged hamsters as effectively as finasteride and combining the two drugs worked better than either one alone.

In an unexpected finding, pathologist and co-author Dolores Di Vizio
'/>"/>

Contact: Keri Stedman
keri.stedman@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. VCU study: Researchers discover a drug combination that shrinks tumors in vivo
2. As girth grows, risk of sudden cardiac death shrinks
3. Drug for advanced kidney cancer shrinks tumors prior to surgery
4. Combination therapy more effective for enlarged prostate
5. Virginia Bioinformatics Institute to model immune responses to gut pathogens
6. New Medicare model guidelines for benefit years 2012-2014 in development
7. Disease transmission model says media coverage cuts infection rate and pandemic extent
8. New model may simplify high-dose radiosurgery planning
9. Treatment for S. aureus skin infection works in mouse model
10. Rheumatoid arthritis signaling protein reverses Alzheimers disease in mouse model
11. Scientists develop the first model for investigating the origins of testicular cancer in humans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2015)... Women’s Excellence is pleased to announce the addition of ... There are over 75 terms and phrases available for viewing, ... gives our patients a better understanding of what our Providers are ... understand. With this resource, our patients are able to go ... and phrases that they may not remember or comprehend at the ...
(Date:3/1/2015)... York, NY (PRWEB) March 01, 2015 ... and seek insurance rates for term or universal policies ... of some of the best life insurance companies for ... through the system at http://quotespros.com/life-insurance.html . , The ... the search portal are tied to a number of ...
(Date:3/1/2015)... Ticket Down is a reputable source for authentic ... Deadheads have been anxiously anticipating this blockbuster weekend ever ... formed 50 years ago back in the 60s in Palo ... untimely death of Jerry Garcia in 1995. This beloved ... rock, bluegrass, folk, space rock and country to become an ...
(Date:3/1/2015)... 2015 ERISAPros is pleased ... Roddy to the professional staff of its Compliance Department. ... The Ohio State University-Mortiz College of Law. Prior to ... working with several Fortune 500 companies as well as ... corporate benefits. Her experiences range from benefit plan design, ...
(Date:3/1/2015)... 2015 CrossFit Attollo is a CrossFit gym ... a special discount to new members. Now through the ... three month contract will receive their fourth month half off. ... members $440. The three month contract is only $264, ... the fourth month comes in at only $55. The special ...
Breaking Medicine News(10 mins):Health News:Best Life Insurance Companies for Single Adults Now Searchable at Insurance Website 2Health News:Grateful Dead Tickets at Soldier Field in Chicago: Ticket Down Slashes Grateful Dead Ticket Prices in Chicago at Soldier Field for 4th of July Weekend Celebration 2Health News:ERISAPros Recruits Evelyn King, J.D. and Carolyn Roddy, J.D. to its Professional Staff 2Health News:CrossFit Gym in Vancouver WA Offers Spring Special 2
... Canadian researchers report , , FRIDAY, July 18 (HealthDay News) -- ... but researchers report they have been able to do that ... pulses into the brain. , Someone with lazy eye -- ... eye is weaker than the other. Early treatment often has ...
... McCain Is Not What America Signed Up For, ... advisor, Phil Gramm, echoed McCain,s comments that America,s,economic problems ... and that America had become a "nation of whiners." ... is now back on board as,McCain,s top economic adviser. ...
... by a Michigan State University scholar refutes commonly held ... and harder to get along with than their "normal ... to guard against the use of weight-based stereotypes when ... Roehling, associate professor of human resource management, and two ...
... Calif., July 18 Actress and best-selling author,Jenny ... in the search,for an autism cure and advocate ... McCarthy incorporated the Global Health Trax(TM) (GHT) flagship,specialty ... and shared her experience in her book Louder ...
... ease symptoms, but old drug offers new hope , , FRIDAY, ... one step back in the search for treatments against Alzheimer,s ... 19 issue of The Lancet , an older drug ... report, a once-promising vaccine failed to prevent the progression of ...
... Cites Work with Women Veterans, WASHINGTON, July 18 ... Center for Post Traumatic,Stress Disorder (PTSD), received the 3rd ... with PTSD and women veterans., "Dr. Schnurr,s contribution ... to healing those who have borne the battle,",said Secretary ...
Cached Medicine News:Health News:Magnetic Pulses to Brain Improve Lazy Eye in Adults 2Health News:Magnetic Pulses to Brain Improve Lazy Eye in Adults 3Health News:DNC: McCain Watch: The Economy 2Health News:DNC: McCain Watch: The Economy 3Health News:Studies refute common stereotypes about obese workers 2Health News:Global Health Trax Joins Fight Against Autism With Jenny McCarthy and Generation Rescue 2Health News:Alzheimer's Research Brings Progress, Setbacks 2Health News:Alzheimer's Research Brings Progress, Setbacks 3Health News:Alzheimer's Research Brings Progress, Setbacks 4
(Date:3/2/2015)... , March 2, 2015 Valencia Technologies Corporation ... patient with its radically small device for the ... early results in this randomized, double-blinded, controlled trial are ... of confidence that it will succeed in a large ... early clinical results, Valencia has ...
(Date:3/2/2015)... 2015 Following announcements from both Novartis ... BioPharma Inc. (NASDAQ:  ARRY) today announced the completion ... with Novartis.  Along with global ownership of both ... $85 million from Novartis. Ron Squarer, ... of the Novartis-GSK transaction, Array now owns both ...
(Date:3/2/2015)... , March 2, 2015  Galmed Pharmaceuticals Ltd. (Nasdaq: ... focused on the development and commercialization of a once-daily, ... cholesterol gallstones, today announced that Josh Blacher , ... the 27th Annual ROTH conference in Laguna ... at 2:30 PM Pacific Standard Time. A live webcast ...
Breaking Medicine Technology:Valencia Technologies Implants its 48th Patient, Continues Equity Crowdfunding 2Array Announces Completion Of Binimetinib And Encorafenib Transactions 2Array Announces Completion Of Binimetinib And Encorafenib Transactions 3Array Announces Completion Of Binimetinib And Encorafenib Transactions 4Array Announces Completion Of Binimetinib And Encorafenib Transactions 5Galmed Pharmaceuticals to Present at the 27th Annual ROTH Conference 2
... , SAN ... marketer of the VerifyNow® System, the first rapid and easy-to-use ... agents (e.g. Plavix® and aspirin), announced today that Timothy I. ... Chief Financial Officer of Accumetrics, will be presenting a corporate ...
... , RALEIGH, N.C., Nov. 24 ... for the pharmaceutical and biotech industry, today announced the launch ... The new Hospital Marketplace e-course is the newest ... a comprehensive series of e-courses designed to fill the critical ...
Cached Medicine Technology:Accumetrics to Present at the 21st Annual Piper Jaffray Health Care Conference 2Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 2Pharmaceutical Institute Launches New Training Resource Focused on the Hospital Marketplace 3
DMSO-resistant microplate sealing film...
Amplification Tape 96 featuring 3M adhesive technology. Good optical quality. Minimal autofluorescence. Certified RNase and DNase free....
Empore Sealing Tape Pads are ideal for covering a 96 well plate during storage or transfer to another work station. Not intended for use with auto-injectors....
... Microseal 'B' seals provide an adhesive-based ... microplates. The aggressive adhesive layer ensures secure ... cycling, and tight sealing during thermal cycling ... heated lid. The perforated end-tabs can be ...
Medicine Products: