Navigation Links
Cholesterol drug may have role in treating prostate cancer

TORONTO, Ont., Sept. 20, 2010 A drug commonly prescribed for people with high cholesterol may also be effective in treating prostate cancer, according to new research by Dr. Xiao-Yan Wen at St. Michael's Hospital.

Rosuvastatina statin drug sold as Crestorsuppressed the growth of transplanted human prostate cancer cells in mice.

"Our data provided solid pre-clinical evidence and a strong rationale for clinical trials of statins in the treatment of prostate cancer," said Wen, whose research appears in the September issue of European Urology, the journal of the European Association of Urology.

Prostate cancer is the most common cancer in Canadian men one in seven men will develop the disease during his lifetime and one in 27 will die from it. Despite improvements in treatments such as surgery, radiation and chemotherapy, many patients still progress to advanced stages.

Recent clinical trials have shown encouraging results regarding the use of angiogenic inhibitorssubstances that prevent the growth of blood vessels that feed tumors.

Wen and his colleagues in Canada and China screened 2,000 small molecules in zebrafish embryos with 2,000 small molecules. Seven compoundsfour of them statinsslowed or prevented the growth of those blood vessels. They then decided to investigate the cancer-fighting potential of one of those statins, rosuvastatin, and found it suppressed the growth of prostate cancer in mice without apparent side effects.

If human trials confirmed that statin drugs can optimize the benefits of radiation, that would help doctors determine the most effective, less toxic and affordable treatments for their prostate cancer patients.


Contact: Leslie Shepherd
St. Michael's Hospital

Page: 1

Related medicine news :

1. Compounds in non-stick cookware may be associated with elevated cholesterol in children and teens
2. Chemicals in Rugs, Cookware May Be Linked to Raised Cholesterol in Teens
3. Study Suggests Statins Could Help Some With Normal Cholesterol
4. Cholesterol Levels Fluctuate With Menstrual Cycle
5. Genome Studies Point to Cholesterol-Regulating Genes
6. High Cholesterol in Youth Boosts Heart Risk In Middle Age
7. No firm conclusions about HDL cholesterol can be drawn from JUPITER sub-analysis
8. Some on Statins May Not Need Boost in Good Cholesterol
9. New links between cholesterol and depression in the elderly
10. Screening Guidelines Miss Many Kids With High Cholesterol
11. Good HDL Cholesterol Now Tied to Lower Cancer Risk
Post Your Comments:
(Date:12/1/2015)... ... December 02, 2015 , ... ... Gastrointestinal events and association with initiation of treatment for osteoporosis ”. , As ... of pharmacological treatment in patients diagnosed with osteoporosis. Based on a large US ...
(Date:12/1/2015)... , ... December 01, 2015 , ... According to an ... groups has filed a discrimination claim against the U.S. Department of Health and Human ... Affordable Care Act (ACA) plans are breaking the clause in the law prohibiting the ...
(Date:12/1/2015)... Houston, TX (PRWEB) , ... December 01, 2015 , ... ... owner of Vitenas Cosmetic Surgery, has been named by MedEsthetics magazine as the Best ... best of the best among the many elite aesthetic physicians honored by the industry ...
(Date:12/1/2015)... ... December 01, 2015 , ... December 1, 2015—Since ... improvements in scientific research and discoveries, leading us to better understand the disease’s ... to those affected by HIV/AIDS. Mediaplanet’s cross-platform edition of “World AIDS Day” provides ...
(Date:12/1/2015)... ... December 01, 2015 , ... ... the United States. Podiatrists are well aware that psychology-based patient non-compliance (disobedience of ... often catastrophic contributors to diseases of the diabetic foot. The American Board ...
Breaking Medicine News(10 mins):
(Date:12/1/2015)...  Athletic apparel company Tommie Copper , ... $1.35 million to settle Federal Trade Commission charges ... clothing would relieve severe and chronic pain and ... Tommie Copper,s proposed settlement with ... founder and chairman Thomas Kallish to ...
(Date:12/1/2015)... , 1 de diciembre de 2015 /PRNewswire/ ... para cuchillas de precisión, develó hoy un ... identidad de marca. El nuevo logo destaca ... y la ingeniería de productos con cuchillas ... ...
(Date:12/1/2015)... PUNE, India , December 1, 2015 ... to a new market research report "Nucleic Acid Labeling ... Techniques (PCR, Nick Translation, Random Primer, In Vitro Transcription, ... to 2020", published by MarketsandMarkets, The global market is ... USD 1,271.8 Million in 2015, growing at a CAGR ...
Breaking Medicine Technology: