Navigation Links
Cholesterol byproduct blocks heart health benefits of estrogen
Date:9/16/2007

sdorf, a Howard Hughes Medical Institute investigator at UT Southwestern. This study not only illustrates the damaging effects high cholesterol has on the heart but also supports the notion that the relative levels of 27HC and estrogen in the vasculature are contributing factors to the risk for cardiovascular disease.

In normal premenopausal women, the amount of 27HC generated from cholesterol is relatively low compared to the level of estrogen circulating in the blood, leading to enhanced cardiovascular protection. In contrast, when the level of 27HC is higher relative to estrogen, such as during the postmenopausal period or as a consequence of high cholesterol, the researchers speculate that 27HC out-competes estrogen to bind with estrogen receptors, blocking the function of the receptors and resulting in a loss of protection.

This model may help explain why women are better protected than men from cardiovascular disease until they reach menopause, said Dr. Mangelsdorf.

The findings also may help explain why a large clinical trial that evaluated certain hormone replacement therapies (HRT) in postmenopausal women a component of the 15-year Womens Health Initiative had to be halted in 2002 when the hormones appeared to increase a womans risk of heart disease.

In the Womens Health Initiative research program, the women who began taking HRT were an average of 13 years postmenopause, Dr. Manglesdorf said. By the time they started taking this estrogen again, the damage caused by 27HC binding to the estrogen receptors in the cardiovascular system may already have occurred. Once you lose estrogens protection for such an extended period of time, you cant get it back.

The researchers also found that 27HC works predominantly on estrogen receptors in the cardiovascular system. When it binds to estrogen receptors in other tissues, such as reproductive tissues, it has no effect on their reproduction-related functions. This prope
'/>"/>

Contact: Amanda Siegfried
amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Low Cholesterol Linked to Severe Depression and Violent Behavior in Men
2. A better way to measure cholesterol
3. Evening,the best time to take Cholesterol Drug
4. Cholesterol Drugs Prevent Breast Cancer
5. In Search Of A New Drug To Target Cholesterol
6. Testicular cancer linked to high cholesterol
7. Genetics and cholesterol levels
8. Frequent meals can reduce cholesterol
9. Eating More Often May Help Lower Cholesterol
10. Lecithin lowers cholesterol absorption in body
11. Step Aerobics Increases good cholesterol
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... proliferation of endogenous neural precursor cells cannot alone ... From the perspective of neural plasticity, Dr. Yun ... China observed the effects of functional electrical stimulation ... expression of basic fibroblast growth factor and epidermal ... infarct side. The researchers found that functional electrical ...
(Date:4/22/2014)... the New Jersey Institute of Technology (NJIT) today ... the launch of the New Jersey Innovation Institute ... model for business innovation through the leveraging of ... U.S. Senator Cory Booker, Panasonic Corp. of North ... Lieutenant Governor Kim Guadagno, New Jersey Secretary of ...
(Date:4/22/2014)... primary care for low-income patients may ease the ... while improving patient health, researchers have concluded. , ... clinics that avoid costs associated with insurance administration ... admission rates and emergency room visits, according to ... , The researchers estimated that the major ...
(Date:4/22/2014)... risk of pregnancy among women using a newer method ... 10 times greater over a 10-year period than using ... researchers at Yale University and UC Davis has found. ... Contraception , the study found the higher risk ... the brand name Essure. , "This study provides ...
(Date:4/22/2014)... Johns Hopkins scientists have found a way to block ... development of atherosclerosis, the main cause of heart attacks ... humans. The condition develops when fat builds inside blood ... hardened, greatly reducing their ability to feed oxygen-rich blood ... a series of experiments, described April 7 in the ...
Breaking Medicine News(10 mins):Health News:Government and industry leaders herald launch of NJIT's New Jersey Innovation Institute 2Health News:Clinics not bogged down by red tape can ease health cost burdens 2Health News:Risk of pregnancy greater with newer method of female sterilization 2Health News:Risk of pregnancy greater with newer method of female sterilization 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 2Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 3Health News:Scientists alter fat metabolism in animals to prevent most common type of heart disease 4
... influenza testing is associated with reductions in the use ... ,The study was posted online today that ... of Archives of Internal Medicine, one of the JAMA/Archives ... speed at which influenza and other viral diseases are ...
... stress and depression,// may be associated with higher ... in turn are related to an increased risk for ... 22 issue of Archives of Internal Medicine, one of ... studies have linked psychosocial characteristics with cardiovascular disease and ...
... Union after a break of six months. Officials from Hungary ... holding of 3000 geese, and the death of 40 geese. The ... has been confirmed as the deadly H5N1 strain, samples are being ... measures are on to control the spread. A protection zone of ...
... Is the everyday talk of HIV/AIDS falling on deaf ears? ‘Careless’ ... today,// who appear to be completely in-charge of their lives, yet ... ,A new survey has shown that, nearly three out of ... getting HIV. , ,The Body Shop and MTV got ...
... history of abuse by intimate partners have significantly higher ... history of such abuse, according to a study conducted ... ,The higher costs and utilization continued long after the ... University of Washington (UW), and the Harborview Injury Prevention ...
... is how some passengers describe it.// , ... who were infected with a stomach flu-causing bug; norovirus aboard ... , This virus causes a contagious gastric illness, gastroenteritis that ... , The liner’s owner Cunard Line notified ...
Cached Medicine News:Health News:Rapid Flu Testing Decreases Antibiotic Use in Hospitalized Adults 2Health News:Psychosocial Factors Associated With Higher Levels of Inflammatory Markers 2Health News:Fowl Fall in Hungary-Bird Flu Strikes 2Health News:Health Care Costs - Significant for Abused Women 2
(Date:1/15/2014)... Most osteoporosis patients want a choice in the medication ... by Mission Pharmacal Company. The survey, conducted by ... community, revealed that 74 percent of osteoporosis patients surveyed ... other than a pill or a tablet. ...
(Date:1/15/2014)... 15, 2014 AARP Foundation today announced it has established ... from the severe cold weather that has gripped much of ... those in need; so to support these emergency relief efforts ... $250,000, which could mean up to $500,000 in aid. The ...
(Date:1/15/2014)... THOUSAND OAKS, Calif. , Jan. 15, 2014 ... and Amgen (NASDAQ: AMGN ) announced ... to jointly discover and validate new therapeutic targets ... (IBD), a chronic disorder that affects millions worldwide. ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... Healthcare and,Laboratory Corporation of America(R) Holdings (LabCorp(R)) ... agreement to discuss future,possibilities to co-develop new ... diagnostics, metabolic syndrome, oncology and diabetes. Under ... new tests that,could make the biggest impact ...
... of the American Pain Society ... ... sustained pain relief from diabetic neuropathic pain (DNP),compared to placebo-treated patients, according ... (APS) in Tampa, Fla., "This is the first placebo-controlled trial of ...
Cached Medicine Technology:Siemens and LabCorp Enter Agreement to Co-Develop New Clinical Diagnostic Tests 2Siemens and LabCorp Enter Agreement to Co-Develop New Clinical Diagnostic Tests 3Siemens and LabCorp Enter Agreement to Co-Develop New Clinical Diagnostic Tests 4New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain 2New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain 3New Lacosamide Data Provides Evidence for Long-Term Efficacy in Diabetic Neuropathic Pain 4
Codman Hakim Programmable micro offers the ability to optimize the opening pressure of a shunt system before and after implantation. A shunted patient's condition will often change over the course of...
Codman Hakim Programmable valve cylindrical with PrechamberInline offers the ability to optimize the opening pressure of a shunt system before and after implantation. A shunted patient's condition wi...
... V is a low viscosity bone cement, ... vertebroplasty. The bone cement is injected into ... Osteopal V is used for the augmentation ... zirconium dioxide is included in the cement ...
Leadpoint Micro-Electrode Recording...
Medicine Products: