Navigation Links
Cholesterol and Alzheimer's: A Big Step Forward
Date:8/12/2013

Boston, Massachusetts (PRWEB) August 12, 2013

For several years now, researchers have been aware of important links between cholesterol and Alzheimer's disease. A new study by Dr. Dora Kovacs and her team at Massachusetts General Hospital, funded in part by the Cure Alzheimer’s Fund (CAF), brings us one step closer to a potential drug that could interrupt the disease process.

Previous studies have shown that cholesterol can produce the toxic peptide Abeta, which in turn is critical in the early stages of Alzheimer’s pathology. In 2001, Dr Kovacs and her colleagues identified a specific enzyme in the cholesterol pathway, abbreviated as ACAT, involved in the production of Abeta. By inhibiting ACAT, they demonstrated that Abeta production can also be reduced.

In this new paper recently published in the Journal of Neuroscience, Kovacs identifies a mechanism of action that accounts for this relationship between ACAT and Abeta production. A process known as “palmitoylation” is involved. The team also used two known ACAT inhibitors already created to reduce cholesterol, testing which might have the most positive effect in lowering Abeta production.

“This is forward momentum in the search for an effective Alzheimer’s treatment,” said Kovacs.

This careful work points to more potential therapies for Alzheimer’s disease through the use of existing or future drugs. More research will help determine the best methods and compounds for intervention.

“These results are a big step in the right direction,” Tim Armour, president and CEO of Cure Alzheimer’s Fund says. “Dr. Kovacs and her team are giving us data we need to really understand the link between Alzheimer’s and cholesterol and how we can better treat the disease.”

About Cure Alzheimer’s Fund

The Cure Alzheimer’s Fund is governed by a board of directors; administered by a small, full-time staff; and guided scientifically by a Research Consortium. Cure Alzheimer's Fund™ is a 501(c)(3) public charity. Cure Alzheimer’s Fund has supported 72 projects in 51 laboratories of leading Alzheimer’s researchers in the US and abroad.

Read the full story at http://www.prweb.com/releases/2013/8/prweb11010745.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Total Cholesterol Levels Can Be Reduced Naturally, According to New Research Posted at eHealthMax.com
2. hCGTreatments / Diet Doc Weight Loss Diets Announces Medical Diet Plans Designed to Promote Fast Weight Loss While Lowering Cholesterol Levels
3. Natural Ways to Lower Cholesterol Now Examined for Adults Over 40 at eHealthMax.com
4. Specialized treatment helps cholesterol patients who suffer side effects from statins
5. Brandeis scientist invents anti-cholesterol process
6. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces New Prescription Diet Plans Capable of Trimming the Waist and Reducing Cholesterol Levels
7. Cholesterol Drugs Linked to Muscle, Joint Problems: Study
8. Jekyll into Hyde: Breathing auto emissions turns HDL cholesterol from good to bad
9. Cholesterol Drugs Might Boost Kidney Cancer Survival
10. Taking cholesterol-lowering drugs may also reduce the risk of dying from prostate cancer: Study
11. Secondhand Smoke Tied to Lower Good Cholesterol in Teen Girls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... , ... April 24, 2017 , ... ... yesterday, featuring Bring Your Own Device (BYOD) capabilities at Telehealth 2.0, the American ... pre-packaged telehealth bundles, which pairs medical devices with a pre-programmed tablet in a ...
(Date:4/24/2017)... Boulder, CO (PRWEB) , ... April 24, 2017 ... ... 2017 American Educational Research Association’s Outstanding Public Communication of Education Research Award. The ... the public, including education communities. It recognizes a scholar who has demonstrated the ...
(Date:4/24/2017)... ... ... Veteran Theresa James awoke to the sound of her newly ex-husband breaking into ... depicts every parent’s worst nightmare, when her three children were violently taken from her. ... my divorce,” James said. “After the death of my children, I continued to journal. ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... telehealth industry, announces the company’s VideoMedicine mobile platform has launched Quick Care, a ... hours a day, Quick Care provides patients with the option to request and ...
(Date:4/24/2017)... ... April 24, 2017 , ... Rod Burkett, CEO of Gardant Management Solutions, ... Rod has been at the forefront of Gardant since it was founded in 1999. ... overseen the opening of more than 40 new senior living communities. With his leadership, ...
Breaking Medicine News(10 mins):
(Date:4/21/2017)... April 21, 2017 Halo Labs announces the ... particle analysis system called the Horizon at PEGS 2017 ... The new system analyzes sub visible particulate matter in ... particle screening as early as candidate selection and pre-formulation. ... biopharma contract research organization Elion Labs for ...
(Date:4/20/2017)... 2017  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... that it will be participating in the Deutsche Bank ... Hotel in Boston, Massachusetts on ... 11:20 a.m. Eastern Time. A live webcast ... Investor Relations website at http://investor.zimmerbiomet.com .  The webcast ...
(Date:4/20/2017)... Research and Markets has announced the addition of the "Global ... and Increasing Usage of Complex Biologics during the Forecast Period" ... The ... Billion in 2015 to around USD 26 Billion by 2020. ... Rapidly Expanding Injectables Market and Increasing Usage of Complex Biologics during ...
Breaking Medicine Technology: