Navigation Links
Cholesterol and Alzheimer's: A Big Step Forward
Date:8/12/2013

Boston, Massachusetts (PRWEB) August 12, 2013

For several years now, researchers have been aware of important links between cholesterol and Alzheimer's disease. A new study by Dr. Dora Kovacs and her team at Massachusetts General Hospital, funded in part by the Cure Alzheimer’s Fund (CAF), brings us one step closer to a potential drug that could interrupt the disease process.

Previous studies have shown that cholesterol can produce the toxic peptide Abeta, which in turn is critical in the early stages of Alzheimer’s pathology. In 2001, Dr Kovacs and her colleagues identified a specific enzyme in the cholesterol pathway, abbreviated as ACAT, involved in the production of Abeta. By inhibiting ACAT, they demonstrated that Abeta production can also be reduced.

In this new paper recently published in the Journal of Neuroscience, Kovacs identifies a mechanism of action that accounts for this relationship between ACAT and Abeta production. A process known as “palmitoylation” is involved. The team also used two known ACAT inhibitors already created to reduce cholesterol, testing which might have the most positive effect in lowering Abeta production.

“This is forward momentum in the search for an effective Alzheimer’s treatment,” said Kovacs.

This careful work points to more potential therapies for Alzheimer’s disease through the use of existing or future drugs. More research will help determine the best methods and compounds for intervention.

“These results are a big step in the right direction,” Tim Armour, president and CEO of Cure Alzheimer’s Fund says. “Dr. Kovacs and her team are giving us data we need to really understand the link between Alzheimer’s and cholesterol and how we can better treat the disease.”

About Cure Alzheimer’s Fund

The Cure Alzheimer’s Fund is governed by a board of directors; administered by a small, full-time staff; and guided scientifically by a Research Consortium. Cure Alzheimer's Fund™ is a 501(c)(3) public charity. Cure Alzheimer’s Fund has supported 72 projects in 51 laboratories of leading Alzheimer’s researchers in the US and abroad.

Read the full story at http://www.prweb.com/releases/2013/8/prweb11010745.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Total Cholesterol Levels Can Be Reduced Naturally, According to New Research Posted at eHealthMax.com
2. hCGTreatments / Diet Doc Weight Loss Diets Announces Medical Diet Plans Designed to Promote Fast Weight Loss While Lowering Cholesterol Levels
3. Natural Ways to Lower Cholesterol Now Examined for Adults Over 40 at eHealthMax.com
4. Specialized treatment helps cholesterol patients who suffer side effects from statins
5. Brandeis scientist invents anti-cholesterol process
6. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces New Prescription Diet Plans Capable of Trimming the Waist and Reducing Cholesterol Levels
7. Cholesterol Drugs Linked to Muscle, Joint Problems: Study
8. Jekyll into Hyde: Breathing auto emissions turns HDL cholesterol from good to bad
9. Cholesterol Drugs Might Boost Kidney Cancer Survival
10. Taking cholesterol-lowering drugs may also reduce the risk of dying from prostate cancer: Study
11. Secondhand Smoke Tied to Lower Good Cholesterol in Teen Girls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/31/2016)... , ... May 31, 2016 , ... WaterField Designs, an ... professionals, announces the waxed-canvas and leather Duo Dopp Kit , the ideal gift ... or ballistic nylon, the Duo is smartly designed for Dad’s grooming routine. ...
(Date:5/31/2016)... CA (PRWEB) , ... May 31, 2016 , ... Interest ... a primary screening tool and as an orthogonal tool for RNAi hit validation. A ... functional and specific guide RNAs—allows rapid generation of CRISPR RNA (crRNA) collections in arrayed ...
(Date:5/31/2016)... ... 2016 , ... MinerEye today announced that it has been ... by Gartner1 Inc. , Each year, Gartner identifies new Cool Vendors in key ... and their products and services. , According to Gartner, “Gartner's Cool Vendors in ...
(Date:5/31/2016)... ... May 31, 2016 , ... CURE Media Group ... cancer, has added Cancer and Careers to its Advocacy Spotlight ... on continuing successful careers while fighting cancer. , As partners, both organizations will ...
(Date:5/30/2016)... , ... May 30, 2016 , ... ... businesses, announced today the publication of an original infographic, " Health Benefits Reimbursement ... insurance professionals understand how Zane Benefits complies with various federal regulations and reforms. ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... 26, 2016   Change Healthcare , ... network solutions and technology-enabled services designed to ... into a strategic channel partnership with SourceMed, ... solutions and revenue cycle management services that ... rehabilitation clinics to optimize revenue, operational efficiency ...
(Date:5/25/2016)... FDA 510(k) clearance covers Confocal Miniprobes ... and surgical applications Mauna Kea Technologies ... multidisciplinary confocal laser endomicroscopy (CLE) platform, today announced ... the 12 th 510(k) clearance from United ... FDA clearance covers Confocal Miniprobes indicated for use ...
(Date:5/25/2016)... , Deutschland und GERMANTOWN, Maryland ... Zusammenarbeit mit Therawis bedient dringenden ... Brustkrebs   QIAGEN N.V. (NASDAQ: ... heute bekannt, eine Lizenz- und Entwicklungsvereinbarung mit Therawis ... für die Onkologie eingegangen zu sein. Ein erstes ...
Breaking Medicine Technology: