Navigation Links
Cholesterol and Alzheimer's: A Big Step Forward
Date:8/12/2013

Boston, Massachusetts (PRWEB) August 12, 2013

For several years now, researchers have been aware of important links between cholesterol and Alzheimer's disease. A new study by Dr. Dora Kovacs and her team at Massachusetts General Hospital, funded in part by the Cure Alzheimer’s Fund (CAF), brings us one step closer to a potential drug that could interrupt the disease process.

Previous studies have shown that cholesterol can produce the toxic peptide Abeta, which in turn is critical in the early stages of Alzheimer’s pathology. In 2001, Dr Kovacs and her colleagues identified a specific enzyme in the cholesterol pathway, abbreviated as ACAT, involved in the production of Abeta. By inhibiting ACAT, they demonstrated that Abeta production can also be reduced.

In this new paper recently published in the Journal of Neuroscience, Kovacs identifies a mechanism of action that accounts for this relationship between ACAT and Abeta production. A process known as “palmitoylation” is involved. The team also used two known ACAT inhibitors already created to reduce cholesterol, testing which might have the most positive effect in lowering Abeta production.

“This is forward momentum in the search for an effective Alzheimer’s treatment,” said Kovacs.

This careful work points to more potential therapies for Alzheimer’s disease through the use of existing or future drugs. More research will help determine the best methods and compounds for intervention.

“These results are a big step in the right direction,” Tim Armour, president and CEO of Cure Alzheimer’s Fund says. “Dr. Kovacs and her team are giving us data we need to really understand the link between Alzheimer’s and cholesterol and how we can better treat the disease.”

About Cure Alzheimer’s Fund

The Cure Alzheimer’s Fund is governed by a board of directors; administered by a small, full-time staff; and guided scientifically by a Research Consortium. Cure Alzheimer's Fund™ is a 501(c)(3) public charity. Cure Alzheimer’s Fund has supported 72 projects in 51 laboratories of leading Alzheimer’s researchers in the US and abroad.

Read the full story at http://www.prweb.com/releases/2013/8/prweb11010745.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Total Cholesterol Levels Can Be Reduced Naturally, According to New Research Posted at eHealthMax.com
2. hCGTreatments / Diet Doc Weight Loss Diets Announces Medical Diet Plans Designed to Promote Fast Weight Loss While Lowering Cholesterol Levels
3. Natural Ways to Lower Cholesterol Now Examined for Adults Over 40 at eHealthMax.com
4. Specialized treatment helps cholesterol patients who suffer side effects from statins
5. Brandeis scientist invents anti-cholesterol process
6. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces New Prescription Diet Plans Capable of Trimming the Waist and Reducing Cholesterol Levels
7. Cholesterol Drugs Linked to Muscle, Joint Problems: Study
8. Jekyll into Hyde: Breathing auto emissions turns HDL cholesterol from good to bad
9. Cholesterol Drugs Might Boost Kidney Cancer Survival
10. Taking cholesterol-lowering drugs may also reduce the risk of dying from prostate cancer: Study
11. Secondhand Smoke Tied to Lower Good Cholesterol in Teen Girls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... Those ... deal with these feelings, many turn to unhealthy avenues, such as drug or alcohol ... of Marne, Michigan, has released tools for healthy coping following a traumatic event. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
(Date:6/24/2016)... ... 24, 2016 , ... Strategic Capital Partners, LLC (SCP) in ... investment capital for emerging technology companies. SCP has delivered investment events and ... more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research and ... Devices Medical Market Analysis 2016 - Forecast to 2022" ... The report contains up to date financial data derived ... Assessment of major trends with potential impact on the market ... of market segmentation which comprises of sub markets, regional and ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... June 23, 2016 Research and ... Procedure Volumes: Global Analysis (United States, China, Japan, Brazil, ... report to their offering. ... for healthcare business planners, provides surgical procedure volume data ... trends with an in-depth analysis of growth drivers and ...
Breaking Medicine Technology: