Navigation Links
Cholesterol and Alzheimer's: A Big Step Forward
Date:8/12/2013

Boston, Massachusetts (PRWEB) August 12, 2013

For several years now, researchers have been aware of important links between cholesterol and Alzheimer's disease. A new study by Dr. Dora Kovacs and her team at Massachusetts General Hospital, funded in part by the Cure Alzheimer’s Fund (CAF), brings us one step closer to a potential drug that could interrupt the disease process.

Previous studies have shown that cholesterol can produce the toxic peptide Abeta, which in turn is critical in the early stages of Alzheimer’s pathology. In 2001, Dr Kovacs and her colleagues identified a specific enzyme in the cholesterol pathway, abbreviated as ACAT, involved in the production of Abeta. By inhibiting ACAT, they demonstrated that Abeta production can also be reduced.

In this new paper recently published in the Journal of Neuroscience, Kovacs identifies a mechanism of action that accounts for this relationship between ACAT and Abeta production. A process known as “palmitoylation” is involved. The team also used two known ACAT inhibitors already created to reduce cholesterol, testing which might have the most positive effect in lowering Abeta production.

“This is forward momentum in the search for an effective Alzheimer’s treatment,” said Kovacs.

This careful work points to more potential therapies for Alzheimer’s disease through the use of existing or future drugs. More research will help determine the best methods and compounds for intervention.

“These results are a big step in the right direction,” Tim Armour, president and CEO of Cure Alzheimer’s Fund says. “Dr. Kovacs and her team are giving us data we need to really understand the link between Alzheimer’s and cholesterol and how we can better treat the disease.”

About Cure Alzheimer’s Fund

The Cure Alzheimer’s Fund is governed by a board of directors; administered by a small, full-time staff; and guided scientifically by a Research Consortium. Cure Alzheimer's Fund™ is a 501(c)(3) public charity. Cure Alzheimer’s Fund has supported 72 projects in 51 laboratories of leading Alzheimer’s researchers in the US and abroad.

Read the full story at http://www.prweb.com/releases/2013/8/prweb11010745.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Total Cholesterol Levels Can Be Reduced Naturally, According to New Research Posted at eHealthMax.com
2. hCGTreatments / Diet Doc Weight Loss Diets Announces Medical Diet Plans Designed to Promote Fast Weight Loss While Lowering Cholesterol Levels
3. Natural Ways to Lower Cholesterol Now Examined for Adults Over 40 at eHealthMax.com
4. Specialized treatment helps cholesterol patients who suffer side effects from statins
5. Brandeis scientist invents anti-cholesterol process
6. hCGTreatments / Diet Doc hCG Diets & Weight Loss Plans Announces New Prescription Diet Plans Capable of Trimming the Waist and Reducing Cholesterol Levels
7. Cholesterol Drugs Linked to Muscle, Joint Problems: Study
8. Jekyll into Hyde: Breathing auto emissions turns HDL cholesterol from good to bad
9. Cholesterol Drugs Might Boost Kidney Cancer Survival
10. Taking cholesterol-lowering drugs may also reduce the risk of dying from prostate cancer: Study
11. Secondhand Smoke Tied to Lower Good Cholesterol in Teen Girls
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2017)... ... May 22, 2017 , ... An inventor from Columbia, ... a pen. "My wife’s hand was damaged in a firework accident, so she couldn’t ... people with manual problems." , He then designed and created a prototype for the ...
(Date:5/22/2017)... ... May 22, 2017 , ... Faithfully following pop culture, ... squatted, stretched, jumped, toned and shaped through fitness programs. It carries on to skin ... finished off with an irresistible, radiant smile. CDA has found that just ...
(Date:5/21/2017)... ... May 19, 2017 , ... Chris Cornell, 52, was found dead on the night of ... the most respected lead singers in the rock industry would take his own life, but ... FindaTopDoc investigates how mental illness played a role in the death of Chris Cornell ...
(Date:5/21/2017)... CA (PRWEB) , ... May 20, 2017 , ... ... paragraph styled corporate text designs created specifically for use in Final Cut Pro ... process for all media productions. Pixel Film Studios’ ProParagraph Corporate will deliver a ...
(Date:5/21/2017)... ... 2017 , ... Florida Pain Relief Group, a division of Physician Partners of ... Silver Palm Ave., Melbourne, on Monday, May 22. Initially the clinic will be supervised ... practice, PPOA operates 23 pain management clinics in Florida and the Dallas-Fort Worth, Texas ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)... May 8, 2017  Diplomat Pharmacy, Inc. (NYSE: DPLO)., ... ("WRB"), a health care service center company based ... WRB specializes in relationship management programs for leading pharmaceutical ... WRB will join Envoy Health ... services for manufacturers, biotech firms, and other service companies. ...
(Date:5/4/2017)... Fix Inc. (" Fortuna "), a private, clinical-stage biotech ... need for embryonic and fetal stem cells by using direct ... Fortuna announced today the launch of its Scientific ... PhD; Father Kevin FitzGerald , S.J., PhD; Col. (R) ... Giordano , PhD. "We are excited and honored ...
(Date:5/4/2017)... , May 4, 2017  DarioHealth Corp. (NASDAQ: DRIO), ... and big data solutions, today announced that it is ... and STI Technologies Limited to lower diabetes healthcare costs ... STI,s innoviCares card, which is available throughout all provinces ... customers will be eligible for additional savings when shopping ...
Breaking Medicine Technology: