Navigation Links
Cholesterol-Lowering Statins Tied to Tendon Woes
Date:2/29/2008

But these side effects are rare and benefits still outweigh risks, experts say

FRIDAY, Feb. 29 (HealthDay News) -- Cholesterol-lowering statins could raise the risk for tendon problems, French researchers report.

However, "our series suggests that statin-attributed tendinous complications are rare, considering the huge number of statin prescriptions," wrote physicians at Rouen University Hospital.

Reporting in the March issue of Arthritis Care and Research, they drew on a national database of side effects reported in France between 1990 and 2005.

In those years, French doctors reported a total of 4,597 statin-related side effects. About 2 percent of those involved problems such as tendinitis or tendon tears, usually arising within eight months of beginning statin therapy. The year-by-year incidence of reported tendon side effects was small -- 13 of 446 statin-attributed side effects in 2003, 19 of 528 in 2004, and 11 of 421 in 2005.

But there have been other reports of unwanted side effects linked to statins, including an increased risk of brain hemorrhage in people taking the drugs after stroke. Most notably, one 2005 study found a higher incidence of muscle problems with Crestor, the newest and most powerful of the cholesterol-busting medications.

The problem with all such studies, including the new French survey, is that they depend on doctors' reporting side effects, said Dr. Richard Karas, director of the Preventive Cardiology Center and Women's Health Center at Tufts-New England Medical Center, who worked on the Crestor report.

"The proportion of events reported is small," Karas said. "If health-care providers don't consider a side effect to be a side effect, they don't report it."

However, the data reported by the French researchers agrees with that collected in the United States, Karas said. The risk for tendon trouble appears to hit men more often than women, he added. "There is a preponderance of men in both papers, about two to one," he noted.

"The importance of these findings is that they put the issue on the radar screen, so you can see if the risk is the same as in the general population," Karas said.

Another American study of statin side effects, about to be reported, finds that tendon problems are not common but do occur because the drugs impair the mitochondria, the energy-producing units of cells, said Dr. Beatrice Golomb, lead author of that study and an associate professor of medicine and of family and preventive medicine at the University of California at San Diego. This cellular impairment can also lead to muscle problems, she said.

It's impossible to give an overall number for incidence of the tendon problems linked to statin use because, "that depends on the dose of statins and the illness of the patient," Golomb said. "Older people with more medical problems tend to have more side effects."

"However you slice it, the tendon problems are less widely reported than muscle problems," she said.

Golomb and Karas differed on the importance of the adverse side effects of statins, which are among the most widely prescribed drugs in the world.

"I'm strongly in the camp that says there is overwhelming evidence that, overall, statins are safe and play an important role in our attempt to reduce heart attacks and stroke," Karas said. "The overall risk-benefit ratio is tilted strongly toward benefit."

But the balance of benefit over risk applies only "if you happen to be a middle-aged man with heart disease or at risk of heart disease," Golomb said. "For other groups, the risk outweighs the benefits."

More information

There's more on cholesterol-lowering medicines at the American Heart Association.



SOURCES: Richard Karas, M.D., director, Preventive Cardiology Center, Tufts-New England Medical Center, Boston; Beatrice Golomb, M.D., associate professor, medicine and family and preventive medicine, University of California, San Diego; March 2008 Arthritis Care and Research


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Cholesterol-lowering drug linked to sleep disruptions
2. Many Patients Stop Taking Cholesterol-Lowering Drugs
3. New Type of Cholesterol-Lowering Drug Shows Promise
4. Cholesterol-Lowering Drugs May Ease Irregular Heartbeat
5. Stopping Statins After Stroke Doubles Death Risk
6. Research to shed new light on how statins benefit heart patients
7. Statins reduce loss of function, keeping old lungs young - even in smokers
8. Better Prostate Cancer Survival for Men Taking Statins
9. Statins After Bypass Lower Stroke Risk
10. Latest Study Says Statins Dont Slow Alzheimers
11. New Gene-Based Therapy an Alternative to Vytorin and Statins in Heart Disease Prevention and Treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cholesterol-Lowering Statins Tied to Tendon Woes
(Date:1/16/2017)... ... January 16, 2017 , ... Gym Source, America’s leading retailer of premium ... East Hanover, New Jersey. , “We are elated to be opening this new showroom,” ... is designed to give clients a seamless and motivating shopping experience.” , Every fitness ...
(Date:1/16/2017)... ... ... Anybody who may be looking for a substance abuse rehabilitation program with ... a holistic treatment center for addiction located in Marne, MI. This video, which can ... and staff that visited the 2016 Recovery Palooza support event in nearby Grand Rapids. ...
(Date:1/16/2017)... IL (PRWEB) , ... January 16, 2017 , ... ... seating manufacturer Prairie Seating. Prairie’s award-winning Reflection® brand of custom seating systems has ... The acquisition provides Permobil with a platform for innovation and growth in the ...
(Date:1/16/2017)... St. Louis, MO (PRWEB) , ... January 16, 2017 , ... St. Louisans are well-aware ... is here , This year’s influenza shot seems to be having no effect ... public area, at least half of the people around are coughing, sneezing, or sniffling ...
(Date:1/16/2017)... ... January 16, 2017 , ... In 1985, the ... high-level training standards to an international multidisciplinary group of healthcare treatment providers and ... way to further its mission at the grassroots level, iaedp launched MemberSHARE, an ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... -- Verathon ® Inc., a leading manufacturer and marketer of imaging ... Spectrum TM Single-Use video laryngoscopes. The new ... Light Reduction TM technology, which actively optimizes image quality. ... ... Introducing another bright idea from GlideScope(R) Video ...
(Date:1/16/2017)... Jan. 16, 2017  Harrington Discovery Institute at ... – part of The Harrington Project for ... partnership Scholars selected in collaboration with Alzheimer,s Drug ... University of Oxford. Harrington Discovery ... to advance discoveries into new medicines that will ...
(Date:1/16/2017)... PUNE, India , January 16, 2017 According ... Controller, Touchscreen Controller, Multi Display , Smart Display, Graphic LCD Controller), ... Forecast to 2022", published by MarketsandMakets, the market is expected to grow ... 2022, at a CAGR of 9.68% between 2016 and 2022. ... ...
Breaking Medicine Technology: