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Cholesterol-Lowering Drug Shows Promise Against Serious Infections in Sickle Cell Disease
Date:1/19/2010

l in the cell membrane to attach to the cell and form an opening called a pore to gain entry into the cell and ultimately destroy it. Working in both statin-treated cells in the laboratory and in mice, researchers reported that after statin treatment bacterial toxins could bind to cells, but no pore formed and cell death was disrupted.

Mice treated with statins suffered less damage when the bacterial toxin was injected into their lungs. Statins also reduced cell death from tetanus and group A streptococcus toxins. Tuomanen said scientists must still determine exactly how statins act to protect against toxins.

Other authors of this paper include Tamara Pestina, Yunming Hu and Derek Persons (St. Jude) and Angela Boyd and Ernesto Hinojosa (UTHSCSA).

The work was supported in part by the National Institutes of Allergy and Infectious Diseases, the National Heart, Lung, and Blood Institute, the National Institute on Aging and ALSAC.

St. Jude Children's Research Hospital

St. Jude Children's Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit '/>"/>

SOURCE St. Jude Children's Research Hospital
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