Navigation Links
Cholesterol-Lowering Drug Shows Promise Against Serious Infections in Sickle Cell Disease
Date:1/19/2010

gators noted that emergence of pneumococcal bacteria resistant to penicillin underscores the need for new prevention tools.

Statins interfere with the liver's ability to make cholesterol. Several years ago researchers noted possible links between statins and a reduced risk of respiratory infections and sepsis.

In this study, researchers showed statins work in part by dampening expression of the protein found on the surface of cells that pneumococcus uses to gain entry into the cells. That protein is called the platelet-activating factor receptor or PAFr. A variety of factors influence how much PAFr is found on the surface of cells. The chronic inflammation associated with sickle cell and certain other diseases leads to increased PAFr production by cells lining the blood vessels and in the lungs.

Investigators used several methods to show statins reduced the number of PAF receptors on the surface of cells both in the laboratory and in the lungs of mice with SCD. In the laboratory, the suppression of the receptor was reversible with the addition of a compound that blocked statin activity.

But Jason Rosch, Ph.D., said PAFr turned out to be just part of the story. Rosch is a St. Jude postdoctoral fellow and the paper's lead author.

Investigators reported statins even helped sickle cell mice that lacked the genetic instructions for making the mouse version of PAFr battle pneumococcal infection more effectively. The statin-treated mice lived longer and had fewer bacteria in their blood. The drug had no impact on mice that lacked PAFr, but did not have sickle cell disease. Rosch said that suggested statins work in part by reducing inflammation associated with sickle cell disease.

Researchers also found statins interfere with the mechanism by which poisons, or toxins, pneumococcus and other bacteria produce are taken up into cells. Those toxins rely on cholestero
'/>"/>

SOURCE St. Jude Children's Research Hospital
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. Cholesterol-lowering drugs also may protect stem cell transplant patients from GVHD
2. Cholesterol-lowering medicines may be effective against cancer
3. Triglyceride Levels Continue to Rise in the United States Despite Increased Use of Cholesterol-Lowering Medications
4. Cholesterol-lowering drugs may also lower PSA, but whether they cut cancer risk is still not known
5. Discoverers of Small Regulatory RNAs and Cholesterol-Lowering Drugs to Receive Lasker Awards for Medical Research
6. Study shows cholesterol-lowering power of dietitian visits
7. Cholesterol-Lowering Statins Tied to Tendon Woes
8. Cholesterol-Lowering Drugs May Ease Irregular Heartbeat
9. New Type of Cholesterol-Lowering Drug Shows Promise
10. Many Patients Stop Taking Cholesterol-Lowering Drugs
11. Cholesterol-lowering drug linked to sleep disruptions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2014)... Recently, iFitDress.com, a popular supplier of wedding dresses ... new range of high quality party outfits. Additionally, it ... items; they are now provided at discounted prices, up ... of the leading suppliers in the international market. According ... party dresses have flattering looks and fine craftsmanship. ...
(Date:7/26/2014)... 2014 The number of Stryker hip ... litigations since the 2012 recall of Rejuvenate and ABG ... Liebhard LLP reports. According to a case list issued ... been filed in the New Jersey’s Bergen County Superior ... ABG II Modular Hip Stem Litigation, No. 296) A ...
(Date:7/26/2014)... 2014 (HealthDay News) -- Pools can provide much-needed relief ... sick if they swallow too much chlorinated water, experts ... for little ones to get water in their mouth. ... pool, despite warnings from their parents. Although swallowing ... important for parents to realize that ingesting too much ...
(Date:7/26/2014)... “Today, we introduce our new items of ... world. All these models are offered at discounted prices, ... market,” says the CEO of the company. DressesOnlineShops.co.uk is ... occasion outfits. , Ladies have to find a dress ... of the best choices for many ladies worldwide to ...
(Date:7/26/2014)... As reported by Lauren Hunter of ... 3 factors: smaller spaces, multi-generational access, and water consumption. ... 2014 lists, including this article on Freshome , ... a leading manufacturer of steam bath generators, has noticed ... smaller spaces and an effort to reduce water consumption. ...
Breaking Medicine News(10 mins):Health News:High Quality Wholesale Party Dresses Online at iFitDress.com 2Health News:Stryker Hip Lawsuit Filings in State and Federal Litigations Continue to Rise, Bernstein Liebhard LLP Reports 2Health News:Stryker Hip Lawsuit Filings in State and Federal Litigations Continue to Rise, Bernstein Liebhard LLP Reports 3Health News:Don't Let Kids Drink Pool Water 2Health News:Famous Supplier DressesOnlineShops.co.uk Announces Its New Selection of Prom Dresses for the UK Market 2Health News:Amerec Finds Bathroom Design Trends Change Based on Water Consumption and Other Factors 2
... oral use of RU-486,s companion drug misoprostol is safe, but ... use of a drug given with RU-486 to terminate a ... infections seen in women taking the drugs since 2000, a ... drug misoprostol is FDA-approved to be taken by mouth along ...
... awarded to IDC in ... Pakistan, ... the global leader in the rapidly growing market for,digital radiography, today announced ... Pakistan to install the X-Series 2200,digital radiography (DR) systems in eight A-Class ...
... Clinica - the world,s leading news,service for the medical ... London,s Houses of Parliament have been at risk of ... during the,last three years. This news comes despite warnings ... Parliamentary assurances that the material,discovered in 2005 was safely ...
... Plan honored for service, strategic excellence by federal program, ... today,that the Blue Cross and Blue Shield Association has ... as well as to eight other,affiliated Blue plans., ... 2007 Best of,Blue FEP Plan Excellence winners at its ...
... showed similarities between lesbians, straight men , , MONDAY, June 16 ... remarkable similarities between the brains of gay men and straight ... For example, the brains of straight men and of gay ... the right hemisphere larger than the left, say the Swedish ...
... noninvasive molecular imaging technology, a method has been developed ... cells (MSCs) in the tumors of living organisms, according ... could lead to major advances in the use of ... cancer therapies are still in the early stages of ...
Cached Medicine News:Health News:Abortion drug's off-label use may have led to deaths 2Health News:Abortion drug's off-label use may have led to deaths 3Health News:IDC implements DR systems in eight A-Class military hospitals in Pakistan 2Health News:IDC implements DR systems in eight A-Class military hospitals in Pakistan 3Health News:Palace of Westminster Asbestos Problem Ignored 2Health News:Gay Men, Straight Women Have Similar Brains 2Health News:Gay Men, Straight Women Have Similar Brains 3Health News:Ability to track stem cells in tumors could advance cancer treatments 2Health News:Ability to track stem cells in tumors could advance cancer treatments 3
(Date:7/25/2014)... N.C. , July 25, 2014  Corporate libraries ... including understanding new advancements in technology and how to ... this, libraries in the pharmaceutical and medical device industries ... of the information and services they provide. ... Practices, LLC there are many forces of change that ...
(Date:7/25/2014)... N.C. , July 25, 2014  In today,s ... is costly and challenging - as is managing a ... Is it possible - or even preferable ... If so, where can you combine resources and activities, ... These are just a few of ...
(Date:7/25/2014)... July 25, 2014 /PRNewswire-iReach/ -- "Australia Capsule Endoscopy Systems ... the Australia Capsule Endoscopy Systems market. The report provides ... and average prices (in US dollars) within market segments: ... , Capsule Endoscopes , Capsule Endoscopy Data ... The report also provides company shares and distribution shares ...
Breaking Medicine Technology:Forces of Change Reshaping Corporate Libraries & Information Services 2Using Promotional Efficiency to Support Multiple Products and Indications in the Pharmaceutical Marketplace 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 3Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 4Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 5
... at Leading Urology Meeting Show that Simple Urine Test ... Detection, Reduce Unnecessary Biopsies -- Gen-Probe to Begin Pivotal ... -SAN DIEGO, April 29 Eight studies presented this ... Association (AUA) suggest that Gen-Probe,s (Nasdaq: GPRO ...
... WASHINGTON, April 29 The recent announcement of the REDUCE ... Chicago brings optimism to the prostate cancer community as dutasteride ... shown to lower by 23 percent the risk of prostate ... Men,s Health Network looks forward to this becoming an additional ...
Cached Medicine Technology:Investigational Genetic Test May Help Address Common Problems in Prostate Cancer Diagnosis 2Investigational Genetic Test May Help Address Common Problems in Prostate Cancer Diagnosis 3Investigational Genetic Test May Help Address Common Problems in Prostate Cancer Diagnosis 4Investigational Genetic Test May Help Address Common Problems in Prostate Cancer Diagnosis 5Study Results Present Paradigm Shift; REDUCE Trial Shows New Hope for the Risk Reduction of Prostate Cancer 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: