Navigation Links
Cholesterol Levels May Not Measure Cardiac Risk
Date:1/16/2009

Normal readings showed up in many who had heart attacks, study shows

FRIDAY, Jan. 16 (HealthDay News) -- Nearly three-quarters of patients hospitalized for heart attacks had cholesterol levels indicating they were not at high risk for cardiovascular trouble, a new, nationwide study shows.

The finding points to the possibility that current guidelines on cholesterol levels should be changed, said study author Dr. Gregg C. Fonarow, a professor of cardiovascular medicine and science at the University of California, Los Angeles. His report appears in the current issue of the American Heart Journal.

"The LDL cholesterol range at which people have heart attacks shouldn't be regarded as normal," Fonarow said.

LDL cholesterol, the "bad" kind, collects to form plaques that can eventually block arteries. Guidelines compiled by the U.S. National Heart, Lung and Blood Institute set an LDL cholesterol blood level target of 130 milligrams per deciliter for people with no cardiovascular disease or diabetes and 70 for those at high risk because of factors such as obesity, smoking and high blood pressure.

But the study of nearly 137,000 Americans hospitalized for heart attacks between 2000 and 2006 found that about 72 percent had LDL levels below 130 on admission, while 17.6 percent had LDL levels below 70.

"People with LDL cholesterol levels in the 100 to 130 range may feel they are at low risk," Fonarow said. "In this study, there was nothing normal about having an LDL reading of 100."

The study also looked at levels of HDL cholesterol, the "good" kind that helps prevent artery blockage. Current guidelines recommend an HDL level of 60 or higher, but the study found levels below 40 in 54.6 percent of the heart attack patients.

Only 1.4 percent of patients met the recommendation for both an LDL level of 70 or lower and an HDL reading of 60 or higher, Fonarow noted.

The current National Cholesterol Education Program guidelines were first set in 2001, and were updated in 2004. The NHLBI is expected to review those guidelines in the near future, Fonarow said.

"My opinion, based on the totality of the evidence that has come out, is that it is likely that there will be important revisions to the guidelines, but that should be determined by the individual advisory groups that will be writing them," he said.

In its update of the guidelines, the NHLBI called for more use of measures such as physical activity and weight loss to reduce the risk of heart attack and other cardiovascular problems.

Cholesterol is only one part of the heart risk picture, Fonarow said. Risk climbs higher with age, especially for men and for those with close relatives who have had cardiovascular conditions.

"The good news is that as much as 80 percent of the risk factors are under individual control and are modifiable," Fonarow said. "You can't control your family history, age or sex, but you can keep your blood pressure low, exercise and modify your lifestyle in other ways to reduce risk."

While calling the study "excellent," Dr. Manesh Patel, an assistant professor of medicine at Duke University, added, "The problem is that this is a snapshot, but we're not sure we know all the risk factors and how they interplay."

The researchers did not measure blood levels of other molecules involved in cardiovascular disease, such as the inflammation biomarker C-reactive protein and lipoprotein(a), he said.

But it's quite possible that the cholesterol guidelines will be changed, Patel said. "Ongoing studies have led to getting the LDL level to 100 and then to 70," he said. "As more randomized trials come out, there may be further changes."

More information

For the full cholesterol story, go to the U.S. National Library of Medicine.



SOURCES: Gregg C. Fonarow, M.D., professor, cardiovascular medicine and science, University of California, Los Angeles; Manesh Patel, M.D., assistant professor, medicine, Duke University, Chapel Hill, N.C.; Jan. 12, 2009, American Heart Journal


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Most heart attack patients cholesterol levels did not indicate cardiac risk
2. Synthetic HDL: A new weapon to fight cholesterol problems
3. FDA Backs Cholesterol Drug Vytorin
4. Study Shows Fish Oils Dramatically Improve Cholesterol Levels in Professional Football Players
5. (Multimedia Version): Abbott Receives FDA Approval for TRILIPIX(TM) (fenofibric acid), First and Only Fibrate Indicated for Use in Combination With a Statin for Cholesterol Management
6. Abbott Receives FDA Approval for TRILIPIX(TM) (fenofibric acid), First and Only Fibrate Indicated for Use in Combination With a Statin for Cholesterol Management
7. 11 New Cholesterol Genes Identified
8. Statin Reduces Heart Attack, Stroke Rates in Patients With Normal Cholesterol but Elevated C-Reactive Protein
9. Triglyceride Levels Continue to Rise in the United States Despite Increased Use of Cholesterol-Lowering Medications
10. Cholesterol-lowering drugs may also lower PSA, but whether they cut cancer risk is still not known
11. Cholesterol Drugs May Raise Post-Op Delirium Risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Cholesterol Levels May Not Measure Cardiac Risk
(Date:10/13/2017)... ... October 13, 2017 , ... ... Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate ... primary prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for ... for action towards gender equality at their inaugural Summit in New York City in ... reached a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... , Sept. 22, 2017 AVACEN Medical ... device is now successfully helping those with the widespread ... Fibromyalgia diagnosed Amanda in Essex, England ... and washing my hair, experiencing no sleep at all, ... painful spasm… I cannot recommend [the AVACEN 100] enough, ...
(Date:9/19/2017)... Ky. , Sept. 19, 2017   ZirMed Inc ... predictive analytics, today announced that it has been ranked #1 ... Black Book™ Rankings 2017 User Survey. ZirMed was ... solution for large hospitals and medical centers over 200 beds ... Black Book,s healthcare technology user survey history. ...
(Date:9/18/2017)... PROVIDENCE, R.I. , Sept. 18, 2017 ... in the fields of bioinformatics and immune ... to develop a protective avian influenza A (H7N9) vaccine. ... is distantly related to seasonal influenza and ... approaches, which rely on prior exposure to be ...
Breaking Medicine Technology: