Navigation Links
Cholesterol Drug Tied to Sleep Disturbances
Date:11/7/2007

But Zocor, a statin, still offers significant heart benefits, researchers say

WEDNESDAY, Nov. 7 (HealthDay News) -- Lowering your cholesterol could interrupt your slumber.

A new report found that the statin Zocor disrupts sleep patterns in some users.

"The study suggests that simvastatin [Zocor] is more likely to have sleep disruption," said Dr. Sidney Smith, past president of the American Heart Association and director of the Center for Cardiovascular Science and Medicine at the University of North Carolina School of Medicine. "The extent to which this would be a significant problem for patients is uncertain, but this should raise awareness that symptoms could be related to therapy."

The findings were presented Wednesday at the American Heart Association's annual meeting, in Orlando, Fla.

A growing number of Americans now take statins to reduce their cholesterol levels, as a way to prevent heart attack or stroke.

"There had long been concerns about statins adversely affecting sleep in case reports and case series dating back to at least 1990, just after the release of statins," said study author Dr. Beatrice Golomb, of the University of California, San Diego, School of Medicine's Department of Medicine. "The rub is that they used sample sizes that were tiny and follow-ups of only four to six weeks. The sample sizes were less than 20 or 30 -- not enough typically to show an effect unless the effect was huge," Golomb noted.

The new study, funded by the U.S. National Institutes of Health, is the largest of its kind and involved 1,106 healthy adult men and women who were randomly chosen to receive 20 milligrams of Zocor (simvastatin), 40 milligrams of Pravachol (pravastatin), or a placebo for six months. The two dosages of the two statins are considered approximately equivalent.

"We were looking at the impact of the most hydrophilic [Pravachol] and most lipophilic [Zocor] statins on a range of non-cardiac endpoints with sleep as a pre-specified secondary outcome," Golomb explained.

Lipophilic means the drug is soluble in fat, while hydrophilic means it is soluble in water. Previous research had implicated lipophilic statins in sleep disturbances.

"Simvastatin is fat-soluble, and can penetrate and cross into the brain," Smith explained.

Golomb said: "We did show significant worsening in both sleep quality outcome and sleep problem categories in patients taking simvastatin. Less sleep quality and more sleep problems."

Those participants who had worse sleep also showed a worsening in their aggression scores, compared to people in the other two study groups.

This doesn't mean that patients experiencing sleep problems should take themselves off Zocor or another statin, Smith said. "The broader benefit of decreasing heart attack and stroke must be taken into account," he said.

And patients who find themselves truly sleep-deprived can also talk to their doctor about finding an alternate statin, he said.

More information

Visit the National Sleep Foundation for more on sleep disorders.



SOURCES: Beatrice Golomb, M.D., Ph.D., associate professor, medicine and family and preventive medicine, University of California, San Diego School of Medicine; Sidney Smith, M.D., past president, American Heart Association, and director, Center for Cardiovascular Science and Medicine, University of North Carolina School of Medicine, Chapel Hill; Nov. 7, 2007, presentation, American Heart Association annual meeting, Orlando, Fla.


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New review suggests caution on drugs to raise good cholesterol
2. Ability to cope with stress can increase good cholesterol in older white men, study finds
3. Handling Stress Properly Increases Good Cholesterol
4. When Good Cholesterol Goes Bad
5. Good Cholesterol Wont Help Heavy-Drinking Older Men
6. Mega Events in September Allow Heart Health Campaign to Reach Tens of Thousands of Hispanics During Cholesterol Awareness Month
7. September: Time to Try Cholesterol-Free Soyfoods
8. LifeMasters Provides Tips for Maintaining a Healthy Blood Cholesterol Level
9. Guacamole: Fights Hunger, Cholesterol and Cancer
10. Mega Events in September, Including Chicago Event This Sat./Sun., Allow Heart Health Campaign to Reach Tens of Thousands of Hispanics During Cholesterol Awareness Month
11. Screening Proposed for Childhood Cholesterol Levels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/29/2017)... , ... March 29, 2017 , ... Hamlin Dental Group, ... is now offering laser dental treatments. Dental lasers are safe and effective options, and ... patients’ options and can improve the overall quality of care. , Dr. Hamid Reza ...
(Date:3/29/2017)... ... March 29, 2017 , ... AvePoint , the Microsoft Cloud expert, is ... Richmond, Virginia, located at the Riverfront Plaza, 901 East Byrd Street. AvePoint is celebrating ... Ralph S. Northam and Mayor of Richmond Levar M. Stoney. , Founded in 2001, ...
(Date:3/28/2017)... ... ... For many women, getting birth control isn’t as easy as it should be. In fact, ... to a health care facility or a pharmacy within 60 minutes of where they live. ... for many who are faced with health or personal issues that leave them homebound. To ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... representatives in state legislatures and Congress to protect parental rights and civil liberties, ... and safety in America. , The demonstration coincides with a press conference taking ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... and services, is proud to announce it has joined the National Association for ... the interests of chronically ill, disabled, and dying Americans of all ages and ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... March 29, 2017 FinancialBuzz.com News Commentary  ... The U.S. could see ... a new report published by New Frontier Data, the legal cannabis ... pace of cannabis legalization in the United States ... considered to be a major factor that drives growth in this ...
(Date:3/28/2017)... , March 28, 2017  Las Vegas ophthalmology practice, ... XEN45 Gel Stent (Allergan, Dublin ), ... the eye, thereby reducing intraocular pressure in patients with ... globally are affected by glaucoma that can lead to ... and blindness, if left untreated. According to ...
(Date:3/28/2017)... 28, 2017 Summary ... Digital as a Key Component of Multichannel Marketing" ... marketing landscape in the digital age. While ... provide medical advancements, it has been much slower ... relying on traditional channels and methods. However, the ...
Breaking Medicine Technology: