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Cholesterol Drug Controversy Continues
Date:3/30/2008

g in 2006 because of a trial showing higher mortality among those taking it.

"It was a new drug, the first in its class," Krumholz said. "The laboratory results looked great, and it ended up hurting people."

It's not clear whether the same will be true of Vytorin, he said. "The evidence we have on hand makes a benefit less likely," Krumholz said. "We have a $5-billion-a-year market without outcomes data."

His journal paper noted that use of statins remained constant in Canada but has declined in the United States as use of Vytorin rose.

"We did not push statins to the maximum," Krumholz said. "That is definitely the wrong thing to do."

More information

The various kinds of cholesterol and what can be done about them are described by the American Heart Association.



SOURCES: B. Greg Brown, M.D., professor, medicine, University of Washington School of Medicine, Seattle; Harlan Krumholz, M.D., professor, medicine, Yale University School of Medicine; March 30, 2008, presentation, American College of Cardiology annual meeting, Chicago; April 3, 2008, New England Journal of Medicine


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