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Choice of career is a major risk factor for persistent neurodermatitis
Date:9/7/2010

ly increasing, and some estimates put it as high as 20% in Europe.

Neurodermatitis may become manifest in infancy, but often clears up as children get older. In some cases, the disorder resolves itself during early adolescence whereas, in other individuals, puberty markedly exacerbates the condition. "It is known that a patient's choice of career is one factor that plays a role", explains Radon, "but there was no way to predict how the disorder might progress as patients got older. We have re-evaluated data from several previous studies on asthma and allergies, which has allowed us to obtain a general picture of the course of atopic dermatitis during puberty, to identify exacerbating factors and to model its development in individual cases."

Data on almost 4000 subjects were analyzed in the study, which was financed by the Federal Ministry for Employment and Social Welfare and the Federal Centre for Occupational Health and Safety. The onset and progression of atopic dermatitis in a follow-up patient cohort at 9-11 and 16-20 years was compared, and factors associated with primary manifestation, re-emergence or maintenance of a pre-existing condition during adolescence were assessed. In about 7% of the participants, atopic dermatitis first appeared during this phase, with girls being at higher risk of developing the condition during their teenage years. Conversely, boys were overrepresented among younger patients. As expected, the chance of developing neurodermatitis increased significantly if a close relative suffered from the disorder.

"Children who were breast-fed, have siblings and attended kindergarten tend not to develop the condition in early childhood", says Peters. "Strikingly, these factors have much less effect on risk for the late-onset form. Occupational exposure to irritating substances seems to be the only predisposing factor of major significance in cases of late-onset neurodermatitis." Groups that are at increased risk incl
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Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

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