Navigation Links
Chlordecone exposure and risk of prostate cancer
Date:6/22/2010

In an article to be published on 21 June 2010 in the Journal of Clinical Oncology, researchers from Inserm (Inserm unit 625 Research Group on Human and Mammalian Reproduction, University of Rennes 1), the CHU (University Hospital Centre) in Pointe Pitre (urology department, University of the French West Indies and Guiana) and from the Center for Analytical Research and Technology (University of Lige, Belgique), show that exposure to chlordecone (also named Kepone), an organochlorine chemical with well defined estrogenic properties used in the French West Indies until 1993, is associated to a significant increased risk of prostate cancer.

Chlordecone is an organochlorine insecticide used in the French West Indies from 1973 to 1993 to control the banana root borer. Permanently polluted soils and waters have remained the primary source of foodstuff contamination, and humans being continue to be exposed to this chemical. Chlordecone is recognized as endocrine disruptor, and is classified by IARC/WHO as possibly carcinogenic to humans.

Research results to be published in the Journal of Clinical Oncology come from an interdisciplinary prostate cancer epidemiology program named Karuprostate (from Karukera, the original Caribbean name of Guadeloupe). A case control study compared the characteristics of 709 consecutive incident cases of prostate cancer and 723 controls without prostate cancer. One of the main objectives of the research programme was to test the hypothesis that chlordecone exposure favors the development of prostate cancer in the French West Indies. Chlordecone exposure was evaluated by measuring its concentration in the blood.

The analysis of the results by the researchers shows that chlordecone exposure is associated to a significant increase in the risk of prostate cancer with increasing plasma chlordecone concentration. These results are supported by the fact that men, presenting genetic variations which
'/>"/>

Contact: Luc Multigner
luc.multigner@inserm.fr
33-144-236-086
INSERM (Institut national de la sant et de la recherche mdicale)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Lead Exposure May Contribute to ADHD
2. NIH takes step to assess any possible risk associated with low-dose radiation exposure
3. Mount Sinai finds prenatal exposure to certain chemicals affects childhood neurodevelopment
4. Prenatal exposure to flame-retardant compounds affects neurodevelopment of young children
5. Smoking Exposure Now Linked to Colon, Breast Cancers
6. Childhood Lead Exposure Causes Permanent Damage: Study
7. Childhood lead exposure causes permanent brain damage
8. Childhood Lead Exposure Causes Permanent Brain Damage
9. Can Exposure to Low Oxygen Levels Benefit Heart Failure Patients?
10. Lead Exposure May Affect Mental Health
11. Unindicated CT series result in unnecessary radiation exposure for patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Spending time online has the potential to ward off ... according to research published online in The ... Sciences . In the article " Internet Use ... States: A Longitudinal Analysis ," the authors report that ... by 33 percent among their study sample. , ...
(Date:4/17/2014)... It,s not uncommon these days to find a colored ribbon ... signify breast cancer. But what color ribbon does one think ... the designated color, for many suffering from the disease, black ... State University study consisting of lung cancer patients, primarily smokers ... shedding more light on the stigma often felt by these ...
(Date:4/17/2014)... 40 years away from a food shortage that will ... a top scientist at the U.S. Agency for International ... production will be limited on a global scale by ... Fred Davies, senior science advisor for the agency,s bureau ... destabilizing by 2050 as energy issues are today.", Davies, ...
(Date:4/17/2014)... TORONTO, April 17, 2014 Giving patients adrenaline after they ... not increase their prospects of surviving long-term, according to ... vast number of patients who have a cardiac arrest ... treating cardiac arrest for decades," said Dr. Steve Lin, ... Michael,s. "Yet, despite advances in medical treatment, long-term survival ...
(Date:4/17/2014)... called for more research to be carried out ... sub-Saharan Africa. In a paper in The ... working with colleagues in the department of Parasitology ... Cleveland Ohio, University of Cambridge and the Royal ... joint burden of HIV/AIDS and schistosomiasis of children, ...
Breaking Medicine News(10 mins):Health News:Internet use may cut retirees' depression 2Health News:Unraveling the 'black ribbon' around lung cancer 2Health News:Food shortages could be most critical world issue by mid-century 2Health News:Adrenaline does little to increase patient's survival after cardiac arrest 2Health News:More research called for into HIV and schistosomiasis coinfection in African children 2
... , AVENTURA, Fla., Dec. 21 Cinergy ... benefit programs for the consumer market, expressed its concern for the ... this morning. , "While the Senate and House healthcare bills are ... step towards expanding access to affordable health coverage for all Americans," ...
... on edibles that will signal fullness just by chewing ... possible to create foods with hunger-suppressing aromas that would offer ... scientists say. , Researchers have long attempted to develop foods ... until recently, have focused on the effects of food in ...
... powerful results in mice and people, researchers say , ... a protein that may be involved in the development ... to new drugs to fight this growing worldwide scourge. ... inhibiting this pathway worked to block pain associated with ...
... ... schedules have been finalized for the ,second annual Dr. Alec Kessler Memorial High School ... Center., , ... (Vocus) December 21, 2009 -- The teams and the tournament schedules have been finalized for ...
... , BOCA RATON, Fla., Dec. 21 Flipping ... system for children and adults, has teamed up with Fisher ... to the retail value of $10,000 - to the children ... In an effort to make the holidays a bit ...
... , , AARP PENNSYLVANIA KEY VOTE NEWS ALERT , ATTENTION ... on key issues throughout the 111th Congress, and informing its nearly ... these key votes. , HARRISBURG, Pa., Dec. 21 The U.S. ... that will begin to bring needed relief to millions of Americans ...
Cached Medicine News:Health News:Cinergy Health Commentary on Senate Healthcare Vote 2Health News:Diabetes Insight Could Lead to Better Treatments 2Health News:Teams And Tournament Schedule Finalized For The Dr. Alec Kessler Memorial High School Basketball Invitational December 28-30, 2009 2Health News:Teams And Tournament Schedule Finalized For The Dr. Alec Kessler Memorial High School Basketball Invitational December 28-30, 2009 3Health News:Flipping for Phonics(TM) Helps Spread Cheer To Military Families In Fisher Houses(R) This Holiday Season 2Health News:Flipping for Phonics(TM) Helps Spread Cheer To Military Families In Fisher Houses(R) This Holiday Season 3Health News:AARP Applauds Senate for Moving Health Care Reform Forward 2Health News:AARP Applauds Senate for Moving Health Care Reform Forward 3
(Date:1/15/2014)... Jan. 15, 2014 MultiCell Technologies, Inc. (OTC Bulletin ... provisional patent application concerning composition of matter, biological targets, ... tumor cell death.  This patent application ... stranded RNA molecules (VSRNAs) which interfere with the basic ...
(Date:1/15/2014)... , Jan. 15, 2014  According to Millennium Research ... market intelligence, the United States ... device markets will expand moderately through 2022, with ... In particular, increasing interest in drug-eluting beads (DEBs) ...
(Date:1/15/2014)... LAVAL, Quebec , Jan. 15, 2014  Valeant Pharmaceuticals ... VRX) announced that the applicable waiting period under the ... to the previously announced tender offer by its indirect ... the outstanding shares of common stock of Solta Medical, ...
Breaking Medicine Technology:MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... Presented Along With Updated Phase 1 Colorectal Cancer ... Data at ... CHICAGO, June 1 /PRNewswire-FirstCall/,-- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ... results,from its ongoing randomized Phase 2 clinical trial in patients ...
... Greater Than 50% Response Rate and 100% Disease Control Rate Observed ... Patients with Medullary Thyroid Cancer, ... encouraging new data from an ongoing phase 1 clinical trial of,XL184, ... with advanced malignancies. The maximum tolerated dose (MTD) for,XL184 has been ...
Cached Medicine Technology:Poniard Announces Positive Preliminary Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in First-Line Treatment of Colorectal Cancer 2Poniard Announces Positive Preliminary Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in First-Line Treatment of Colorectal Cancer 3Poniard Announces Positive Preliminary Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in First-Line Treatment of Colorectal Cancer 4Poniard Announces Positive Preliminary Efficacy and Safety Data From Ongoing Phase 2 Trial of Picoplatin in First-Line Treatment of Colorectal Cancer 5Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO 2Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO 3Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO 4Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO 5Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO 6
The UniCel DxI 800 with its exceptional throughput, proven chemiluminescent technology, assay protocols like Access, Access 2, Synchron LXi 725 and load "on-the-fly" capability simplifies and automat...
... The Access immunoassay system ... access benchtop analyzer that ... assays, with panels that ... thyroid, infectious disease, blood ...
...
...
Medicine Products: