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Chiral metal surfaces may help to manufacture pharmaceuticals
Date:10/26/2011

recognition, in chiral synthesis (forming a chiral product from non-chiral reactants), and in chiral separations.

Driver added: "It looks like alanine can shape a comfortable, chiral bonding site for itself. The copper surface has the flexibility to adapt itself to the shape of the alanine molecule, and this shape is different for the two different molecular enantiomers."

The results imply that certain surface orientations will form stable, ordered structures with one molecular enantiomer but not the other: exactly the right conditions to promote chiral chemical effects.

Professor Sir David King, former Chief Scientific Advisor to the UK Government and current Director of the Smith School of Enterprise and the Environment at Oxford, brought together the team carrying out this research. "These results are very exciting," said King. "Tailoring the right surface to the right molecule should lead to strong enantiospecific effects. We see a real basis here for a breakthrough technology in the pharmaceuticals sector. It's something that pharma companies should be taking a close interest in."

The Cambridge team's findings are published in Topics in Catalysis.


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Contact: Genevieve Maul
Genevieve.maul@admin.cam.ac.uk
44-012-237-65542
University of Cambridge
Source:Eurekalert

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