Navigation Links
Chiral metal surfaces may help to manufacture pharmaceuticals
Date:10/26/2011

le-crystal surfaces. Thanks to a powerful scanning tunnelling microscope, capable of resolving individual atoms and molecules, their work is revealing the various manifestations of chirality that occur, giving important clues to how they arise, and how they might be controlled and exploited.

Dr Stephen Driver, of the Department of Chemistry at the University of Cambridge, who led the experimental work, said: "We set out to investigate two distinct scenarios. In one scenario, the surface is non-chiral, so any chirality that we see can only arise from the chirality of the alanine molecule. In the other scenario, we move to a surface that is intrinsically chiral. Now the question becomes: do the two enantiomers of alanine behave differently on this chiral surface?"

On the non-chiral surface, the researchers found that alanine can self-organise into either of two patterns. In one of these, the self-organisation is driven by hydrogen bonding between the molecules, while the chiral centre has no discernable impact on the regular array. In the other structure, a network of long-range chiral boundaries punctuates the array, and the boundary chirality switches with molecular chirality.

Driver explained: "The implication is that the chiral centre is having a direct influence on the packing of two alanine neighbours at the boundary, and that the chirality of this pair propagates to the next pair and the next and so on, so that the chiral boundary is built up over a long range."

The chiral surface is created simply by choosing a surface orientation that lies away from any of the bulk mirror symmetry planes of the metal crystal. When the researchers added alanine, they found that the surface changes its local orientation, forming nanometre-scale facets. The two enantiomers of alanine self-organise into different chiral patterns: a strong, enantiomer-specific structural effect. This "proof of principle" could potentially be exploited in chiral
'/>"/>

Contact: Genevieve Maul
Genevieve.maul@admin.cam.ac.uk
44-012-237-65542
University of Cambridge
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Delhi metallo-beta-lactamase-1 enzyme acquired in Canada
2. LED products billed as eco-friendly contain toxic metals, study finds
3. Red mud disasters main threat to crops is not toxic metals
4. Metal Tongue Piercings Linked to Raised Infection Risks
5. New York Personal Injury Attorney David Perecman Comments On Dangers Of ‘Metal On Metal' Hip Implants
6. Parallels Launches Parallels Server for Mac Bare Metal Edition
7. Phoenix Volleyball Festival Championships Played on SnapSports Volleyball Surfaces
8. Long struggle for appropriately processed manufacturer data leads to a new assessment of memantine
9. Center to revolutionize chemical manufacture is open for business
10. Bling My Sling LL Announces Website Launch - A fashionable arm sling manufacturer, announce the opening of their new website bling-my-sling.com
11. Linguistics professor examines manufacturers prescription drug websites
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... variant specifically associated with the risk of a ... cent of all breast cancer cases. , The ... called invasive lobular carcinoma, gives researchers important clues ... of breast cancer, which can be missed through ... the journal PloS Genetics , was co-led ...
(Date:4/17/2014)... to a study published today in PLOS Pathogens ... where malaria is common can mount an immune response ... to avoid repeated bouts of high fever and illness ... their bloodstream. The findings may help researchers develop future ... the malaria parasite. , Each year, approximately 200 million ...
(Date:4/17/2014)... Colo. (April 17, 2014) Two recent papers ... researcher and colleagues may help scientists develop treatments ... Yellow fever, Japanese encephalitis and other disease-causing flaviviruses. ... biochemistry and molecular genetics at the School of ... Howard Hughes Medical Institute, and colleagues recently published ...
(Date:4/17/2014)... University synthetic biology team has created a new ... therapeutics that could travel the body and selectively ... Engineering cell-based, biological devices that monitor and modify ... synthetic biology. However, no existing technology enabled bioengineers ... physiological state and respond in a customized fashion. ...
(Date:4/17/2014)... It,s estimated that as many as 10 million older ... of loneliness and isolation. , However, new research ... retired older Americans for six years found that ... of depression by more than 30 percent. , "That,s ... State University professor of telecommunication, information studies and media ...
Breaking Medicine News(10 mins):Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Study sheds light on how the immune system protects children from malaria 2Health News:CU researchers discover target for treating dengue fever 2Health News:Building 'smart' cell-based therapies 2Health News:Internet use can help ward off depression among elderly 2
... ... editor of Megaregions: Planning for Global Competitiveness and director of the Center for Quality ... special meeting at The White House Clean Energy Economy Forum: Livability and Sustainable Communities ... ...
... ... ... ... , ...
... dose of vitamin D may just be what Chicagoans need ... Loyola University Chicago Marcella Niehoff School of Nursing (MNSON). This ... short and more time is spent indoors. "Vitamin D ... reported health benefits," said Sue Penckofer, PhD, RN, professor, MNSON. ...
... ... , ... , , ... HOUSTON , ...
... ... ... ... ...
... ... ... , ... , , ...
Cached Medicine News:Health News:Dr. Catherine Ross to Participate Today in White House Clean Energy Economy Forum 2Health News:Dr. Catherine Ross to Participate Today in White House Clean Energy Economy Forum 3Health News:America's Prostate Cancer Organizations Offer Pointers to House Committee on Oversight and Government Reform 2Health News:America's Prostate Cancer Organizations Offer Pointers to House Committee on Oversight and Government Reform 3Health News:America's Prostate Cancer Organizations Offer Pointers to House Committee on Oversight and Government Reform 4Health News:Vitamin D lifts mood during cold weather months 2Health News:Northstar Healthcare Inc. (TSX: NHC) Management Forecasts a Loss of $1.2 Million for 2010 at its Palladium for Surgery - Houston, Ltd. Centre 2Health News:The First Annual CQ HealthBeat Conference 2Health News:The First Annual CQ HealthBeat Conference 3Health News:The First Annual CQ HealthBeat Conference 4Health News:The First Annual CQ HealthBeat Conference 5Health News:AUA Foundation Responds to American Cancer Society Guideline for the Early Detection of Prostate Cancer 2Health News:AUA Foundation Responds to American Cancer Society Guideline for the Early Detection of Prostate Cancer 3
(Date:1/15/2014)...  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced the ... Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ) ... in order to treat dental impairments, for tooth restoration ...
(Date:1/15/2014)... Jan. 15, 2014  Novation, the leading health care supply ... IT value-added reseller (VAR) national contracts that expand its ... services at lower costs. These include manufacturer product and ... initiative assistance and ongoing IT consulting support. ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ... (OFT) approval condition to the announced tender offer for all of ... As a result of the waiver, the transaction is no longer ... offer on January 24, 2014 following the currently scheduled expiration time, ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3
... Nano Mask, Inc. (NMI) (Pink Sheets: NANM ... on emergency and critical care as well as infection ... a distribution agreement with a Saudi Arabia-based medical products ... exclusive basis to: The Kingdom of Saudi Arabia, United ...
... Aug. 25, 2011 The U.S. Food and Drug Administration ... attacks of a rare condition called hereditary angioedema (HAE) in ... (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... the improper function of a protein called C1 inhibitor, which ...
Cached Medicine Technology:Nano Mask Enters Into Four-Year Distribution Agreement With Saudi Medical Products Distributor 2FDA Approves Firazyr To Treat Acute Attacks of Hereditary Angioedema 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: