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Chinks in the brain circuitry make some more vulnerable to anxiety
Date:2/10/2011

scanned, participants viewed various scenarios in which a virtual figure was seen in a computerized room. In one room, the figure would place his hands over his ears before a loud scream was sounded. But in another room, the gesture did not predict when the scream would occur. This placed volunteers in a sustained state of anticipation.

Participants who showed overactivity in the amygdala developed much stronger fear responses to gestures that predicted screams. A second entirely separate risk factor turned out to be failure to activate the ventral prefrontal cortex. Researchers found that participants who were able to activate this region were much more capable of decreasing their fear responses, even before the screams stopped.

The discovery that there is not one, but two routes in the brain circuitry that lead to heightened fear or anxiety is a key finding, the researchers said, and it offers hope for new targeted treatment approaches.

"Some individuals with anxiety disorders are helped more by cognitive therapies, while others are helped more by drug treatments," Bishop said. "If we know which of these neural vulnerabilities a patient has, we may be able to predict what treatment is most likely to be of help."


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Contact: Yasmin Anwar
yanwar@berkeley.edu
510-643-7944
University of California - Berkeley
Source:Eurekalert

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